Polyarginine Cell-Penetrating Peptides Bind and Inhibit SERCA2
Cells, 2023 Cell-penetrating peptides (CPPs) are short peptide sequences that have the ability to cross the cell membrane and deliver cargo. Although it is critical that CPPs accomplish this task with minimal off-target effects, such actions have in many cases not ...
Per Kristian Lunde +6 more
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Role of TG2-Mediated SERCA2 Serotonylation on Hypoxic Pulmonary Vein Remodeling [PDF]
Frontiers in Pharmacology, 2020 Sarco-endoplasmic reticulum Ca2+ ATPase (SERCA) pumps take up Ca2+ from the cytoplasm to maintain the balance of intracellular Ca2+. A decline in expression or activity of SERCA results in persistent store-operated calcium entry (SOCE). In cardiomyocytes
Bo Liu +7 more
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Remote ischemic postconditioning alleviates cerebral ischemic injury through
Microscopy research and technique (Print), 2023 Remote ischemic postconditioning (RIPostC) alleviates brain ischemic injury through several pathways, including endoplasmic reticulum (ER) stress modulation.
Wanying Chen +9 more
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JCI Insight, 2023 Mutation of the ATP2A2 gene encoding sarco-endoplasmic reticulum calcium ATPase 2 (SERCA2) was linked to Darier disease more than 2 decades ago; however, there remain no targeted therapies for this disorder causing recurrent skin blistering and ...
Shivam A. Zaver +7 more
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Zika virus non-structural protein NS2A mediated endoplasmic reticulum stress through interacting with Sarco/endoplasmic reticulum Ca2+-ATPase 2 [PDF]
Journal of VirologyZika virus (ZIKV) infection of neuronal cells leads to endoplasmic reticulum (ER) stress, which is one of the key causes of neuronal damage. However, how ZIKV mediates ER stress has not been fully understood.
Shan Wang +8 more
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Sigma‐1 receptor attenuates osteoclastogenesis by promoting ER‐associated degradation of SERCA2
EMBO Molecular Medicine, 2022 Sigma‐1 receptor (Sigmar1) is a specific chaperone located in the mitochondria‐associated endoplasmic reticulum membrane (MAM) and plays a role in several physiological processes. However, the role of Sigmar1 in bone homeostasis remains unknown. Here, we
Xiaoan Wei +14 more
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SERCA2 regulates non-CF and CF airway epithelial cell response to ozone. [PDF]
PLoS ONE, 2011 Calcium mobilization can regulate a wide range of essential functions of respiratory epithelium, including ion transport, ciliary beat frequency, and secretion of mucus, all of which are modified in cystic fibrosis (CF).
Shama Ahmad +6 more
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SGLT2 inhibitor dapagliflozin reduces endothelial dysfunction and microvascular damage during cardiac ischemia/reperfusion injury through normalizing the XO-SERCA2-CaMKII-coffilin pathways [PDF]
Theranostics, 2022 Background: Given the importance of microvascular injury in infarct formation and expansion, development of therapeutic strategies for microvascular protection against myocardial ischemia/reperfusion injury (IRI) is of great interest.
Li Ma +7 more
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Molecular Metabolism, 2022 Objective: Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) transports Ca2+ from the cytosol into the endoplasmic retitculum (ER) and is essential for appropriate regulation of intracellular Ca2+ homeostasis.
Marco Bauzá-Thorbrügge +10 more
doaj +2 more sources
LncEDCH1 improves mitochondrial function to reduce muscle atrophy by interacting with SERCA2
Molecular Therapy: Nucleic Acids, 2022 Skeletal muscle is a regulator of the body's energy expenditure and metabolism. Abnormal regulation of skeletal muscle-specific genes leads to various muscle diseases.
Bolin Cai +12 more
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