Results 211 to 220 of about 10,338 (254)

The selenocysteine-containing protein SELENOT maintains dopamine signaling in the midbrain to protect mice from hyperactivity disorder. [PDF]

EMBO J
Guo Q, Li ZF, Hu DY, Li PJ, Wu KN, Fan HH, Deng J, Wu HM, Zhang X, Zhu JH.   +9 more
europepmc   +1 more source

Computational modelling for improved translation of cardiac inotropic and lusitropic drug effects from rats to humans. [PDF]

J Pharmacol Toxicol Methods
Jung A, Augustin CM, Voglhuber-Höller J, Kiessling M, Ljubojevic-Holzer S, Mirams GR, Niederer SA, Plank G.   +7 more
europepmc   +1 more source

Identification of a molecular resistor that controls UCP1-independent Ca²⁺ cycling thermogenesis in adipose tissue.

Cell Metab
Auger C, Li M, Fujimoto M, Ikeda K, Yook JS, O'Leary TR, Caycedo MPH, Xiaohan C, Oikawa S, Verkerke ARP, Shinoda K, Griffin PR, Inaba K, Stimson RH, Kajimura S.   +14 more
europepmc   +1 more source

Exploring Mechanisms of Pulmonary Artery Banding in a Rat Model of Dilated Cardiomyopathy. [PDF]

JACC Basic Transl Sci
Ye Y, Topkara VK.
europepmc   +1 more source

Modulation du CA²⁺ intracellulaire et de la phosphorylation en tyrosine durant la capacitation des spermatozoïdes humains : rôles de la Ca²⁺-ATPase SERCA2 et de la tyrosine kinase SRC

, 2008
Christine Lawson
openalex   +1 more source

Infrasound in Biology and Medicine: Insights into Mechanisms, Health Outcomes and Research Perspectives - A Narrative Review.

Noise Health
Kapoor P, Yadav RB, Agrawal N, Gaur S, Arora R.   +4 more
europepmc   +1 more source

Corrigendum to "Expression of Membrane-bound Carbonic Anhydrases IV, IX, and XIV in the Mouse Heart". [PDF]

J Histochem Cytochem
europepmc   +1 more source

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Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure

Circulation, 2023
Background: Increasing SERCA2 (sarco[endo]-plasmic reticulum Ca2+ ATPase 2) activity is suggested to be beneficial in chronic heart failure, but no selective SERCA2-activating drugs are available. PDE3A (phosphodiesterase 3A) is proposed to be present in
J. Skogestad, Ingrid Albert, K. Hougen, Gustav B. Lothe, Marianne Lunde, Olav Søvik Eken, Ioanni Veras, Ngoc Trang Thi Huynh, Mira Børstad, Serena Marshall, Xin Shen, W. Louch, E. Robinson, Joseph C. Cleveland, A. Ambardekar, Jessica A. Schwisow, Eric R. Jonas, A. Calejo, J. P. Morth, K. Taskén, A. O. Melleby, P. Lunde, I. Sjaastad, C. Carlson, J. M. Aronsen   +24 more
semanticscholar   +3 more sources

Targeting SERCA2 in Anti-Tumor Drug Discovery.

Current Drug Targets
SERCA2, a P-type ATPase located on the endoplasmic reticulum of cells, plays an important role in maintaining calcium balance within cells by transporting calcium from the cytoplasm to the endoplasmic reticulum against its concentration gradient.
Wanqian Song, Qiuju Zhang, Zhiyong Cao, Guo Jing, Tiancheng Zhan, Yongkang Yuan, Ning Kang, Qiang Zhang   +7 more
semanticscholar   +3 more sources

SERCA2 phosphorylation at the heart of the disease.

Cell Calcium, 2023
Gonnot et al. [1] thoroughly investigated the regulatory role of glycogen synthase kinase 3 beta (GSK3β) in modulating cardiac isoform 2 of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA2) activity. They have found that in ischemic hearts of patients and mouse-GSK3β -mediated SERCA2 phosphorylation at serine 663 dampens the SERCA2 pump activity ...
M. Brini, Tito Calì
semanticscholar   +5 more sources