Results 221 to 230 of about 10,338 (254)

Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8+ T cell metabolic fitness and function in tumors

Science immunology, 2023
Metabolic fitness of T cells is essential for their vitality, which is largely dependent on the behavior of the mitochondria. The nature of mitochondrial behavior in tumor-infiltrating T cells remains poorly understood.
Jie Yang, Xudong Xing, L. Luo, Xin-Wei Zhou, Jian-Xiong Feng, Kang-Bo Huang, Huashan Liu, Shanzhao Jin, Yi-na Liu, Shi-Hui Zhang, Yi-Hui Pan, Bing-Sheng Yu, Jin-Yu Yang, Yu-Lu Cao, Yun Cao, Cliff Y. Yang, Yuan Wang, Yuxia Zhang, Jiang Li, Xiaojun Xia, Tiebang Kang, Ruifeng Xu, Ping Lan, Jun-hang Luo, Hui-Qiong Han, Fan Bai, Song Gao   +26 more
semanticscholar   +1 more source

Clioquinol inhibits cell growth in a SERCA2‐dependent manner

Journal of Biochemical and Molecular Toxicology, 2021
AbstractClioquinol has been reported to act as a potential therapy for neurodegenerative diseases and cancer. However, the underlying mechanism is unclear. We have previously reported that clioquinol induces S‐phase cell cycle arrest through the elevation of calcium levels in human neurotypic SH‐SY5Y cells.
Xiaoguang Lv, Wei Zhang, Shengli Xia, Zhiwei Huang, Ping Shi   +4 more
openaire   +2 more sources

Tight interplay between the Ca2+ affinity of the cardiac SERCA2 Ca2+ pump and the SERCA2 expression level

Cell Calcium, 2007
A reduced activity of the sarcoplasmic reticulum Ca2+ pump SERCA2a is a hallmark of cardiac dysfunction in heart failure. In SERCA2b/b mice, the normal SERCA2a isoform is replaced by SERCA2b, displaying a higher Ca2+ affinity. This elicited decreased cardiac SERCA2 expression and cardiac hypertrophy.
Peter, Vangheluwe, Marleen, Schuermans, Luc, Raeymaekers, Frank, Wuytack   +3 more
openaire   +2 more sources

Inhibition of SERCA2 Ca2+-ATPases by Cs+

Pfl�gers Archiv - European Journal of Physiology, 2004
Replacement of K(+) with Cs(+) on the cytoplasmic side of the sarcoplasmic reticulum (SR) membrane reduces the maximum velocity (V(max)) of Ca(2+) uptake into the SR of saponin-permeabilized rat ventricular myocytes. To compare the sensitivity of the cardiac and smooth muscle/non-muscle forms of the sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase ...
Gary J, Kargacin, Roozbeh, Aschar-Sobbi, Margaret E, Kargacin   +2 more
openaire   +2 more sources

1751-P: SERCA2 Regulates ER Lipid Composition and Proinsulin Processing

Diabetes, 2023
Endoplasmic reticulum calcium (ER Ca2+) levels are primarily maintained through the sarco-ER Ca2+ ATPase (SERCA) pump. We have demonstrated reduced SERCA2 expression in islets from human cadaveric donors with Type 2 Diabetes (T2D) compared to ...
Maryalice Hartley, M. Pearson, Farooq Syed, Hai Bui, T. Kono, Kenneth D. Roth, C. Evans-Molina   +6 more
semanticscholar   +1 more source

Phospholamban-to-SERCA2 ratio controls the force-frequency relationship

American Journal of Physiology-Heart and Circulatory Physiology, 1999
The force-frequency relationship (FFR) describes the frequency-dependent potentiation of cardiac contractility. The interaction of the sarcoplasmic reticulum Ca2+-adenosinetriphosphatase (SERCA2) with its inhibitory protein phospholamban (PLB) might be involved in the control of the FFR.
M, Meyer, W F, Bluhm, H, He, S R, Post, F J, Giordano, W Y, Lew, W H, Dillmann   +6 more
openaire   +2 more sources

Inhibition of the calcineurin/forkhead box O1/fatty acid binding protein 4 pathway prevents SERCA2 dysfunction‐induced foam cell formation and atherosclerosis

British Journal of Pharmacology
The cysteine residue 674 (C674) of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) is pivotal in maintaining SERCA2 activity. The C674S mutation leads to SERCA2 dysfunction and exacerbates atherosclerosis by inducing endoplasmic reticulum ...
Beibei Zhu, Shuangxue Luo, Hang Su, Wan-Qin Zhang, Qingqiu Chen, Yiping Zhang, Chenyuan Liu, Pan Li, Tingting Wang, Xiaoyong Tong, Pingping Hu   +10 more
semanticscholar   +1 more source

1832-P: SERCA2 Regulates the Lipidome and Insulin Secretion in Pancreatic β-Cells

Diabetes
Introduction and Objective: The sarco-ER Ca2+ ATPase (SERCA2) pump maintains endoplasmic reticulum (ER) Ca2+ levels in the pancreatic β-cell. Previously, we demonstrated reduced SERCA2 expression in islets from human organ donors with type 2 diabetes ...
Maryalice Hartley, Mackenzie J. Pearson, Farooq Syed, Kenneth D. Roth, T. Kono, C. Evans-Molina   +5 more
semanticscholar   +1 more source

PYK2 regulates SERCA2 gene expression in neonatal rat ventricular myocytes

American Journal of Physiology-Cell Physiology, 2005
The nonreceptor protein tyrosine kinase (PTK) proline-rich tyrosine kinase 2 (PYK2) has been implicated in cell signaling pathways involved in left ventricular hypertrophy and heart failure, but its exact role has not been elucidated. In this study, replication-defective adenoviruses (Adv) encoding green fluorescent protein (GFP)-tagged, wild-type (WT)
Maria C, Heidkamp, Brian T, Scully, Kalpana, Vijayan, Steven J, Engman, Erika L, Szotek, Allen M, Samarel   +5 more
openaire   +2 more sources

Severe food restriction induces myocardial dysfunction related to SERCA2 activity

Canadian Journal of Physiology and Pharmacology, 2009
Previous studies have shown that food restriction promotes myocardial dysfunction in rats. However, the molecular mechanisms that are responsible are unclear. We investigated the role of sarcoplasmic reticulum Ca2+-ATPase (SERCA2) on myocardial performance in food-restricted rats.
Sugizaki, Mario Mateus, Leopoldo, Andre Soares, Okoshi, Marina Politi, Bruno, Alessandro, Conde, Sandro Jose, Lima-Leopoldo, Ana Paula, Padovani, Carlos Roberto, Carvalho, Robson Francisco, do Nascimento, Andre Ferreira, Salome de Campos, Dijon Henrique, Nogueira, Célia Regina, Cicogna, Antonio Carlos   +11 more
openaire   +3 more sources