NEXN protects against vascular calcification by promoting SERCA2 SUMOylation and stabilization [PDF]
Nature CommunicationsVascular calcification, a key risk factor for cardiovascular diseases, is driven by the phenotypic transition of vascular smooth muscle cells from a contractile to an osteogenic phenotype.
Wenjie Guo +14 more
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In Vitro Analysis of SERCA2 Gene Regulation in Hypertrophic Cardiomyocytes and Increasing Transfection Efficiency by Gene‐Gun Biolisticsa [PDF]
, 1999 The transcriptional downregulation of the SERCA2 gene is studied using neonatal rat cardiomyocytes stimulated with endothelin-1 to induce hypertrophy. Liposome-based transfection of cells with a 1.9 kb SERCA2 promoter fragment directed expression of a ...
Karin Eizema +4 more
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Nature CommunicationsType 2 diabetes (T2D)-related fragility fractures represent an increasingly tough medical challenge, and the current treatment options are limited. Mechanical loading is essential for maintaining bone integrity, although bone mechano-responsiveness in ...
Xi Shao +13 more
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Unlocking the potential of atractylenolide II: Mitigating non-alcoholic fatty liver disease through farnesoid X receptor-endoplasmic reticulum stress interplay [PDF]
Journal of Pharmaceutical AnalysisEvidences indicate that farnesoid X receptor (FXR) activation mitigates non-alcoholic fatty liver disease (NAFLD) by reducing endoplasmic reticulum (ER) stress.
Ming Gu +7 more
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Induction of MASH-like pathogenesis in the Nwd1 −/− mouse liver [PDF]
Communications BiologyEndoplasmic reticulum (ER) stores Ca2+ and plays crucial roles in protein folding, lipid transfer, and it’s perturbations trigger an ER stress. In the liver, chronic ER stress is involved in the pathogenesis of metabolic dysfunction-associated steatotic ...
Seiya Yamada +10 more
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AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR [PDF]
Circulation Research, 2021 Supplemental Digital Content is available in the text. Background: The sarcoplasmic reticulum (SR) Ca2+-ATPase 2 (SERCA2) mediates Ca2+ reuptake into SR and thereby promotes cardiomyocyte relaxation, whereas the ryanodine receptor (RYR) mediates Ca2 ...
C. Carlson +21 more
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Inactivation of SERCA2 Cys674 accelerates aortic aneurysms by suppressing PPARγ
British Journal of Pharmacology, 2021 Inactivation of Cys674 (C674) in the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) causes intracellular Ca2+ accumulation, which activates calcineurin‐mediated nuclear factor of activated T‐lymphocytes (NFAT)/NF‐κB pathways, and results in ...
Yumei Que +6 more
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Thyroxine increases Serca2 and Ryr2 gene expression in heart failure rats with euthyroid sick syndrome [PDF]
Archives of Endocrinology and Metabolism, 2016 Objective The current study was aimed at analyzing sarcoplasmic reticulum Ca2+ ATPase (Serca2) and ryanodine receptor type 2 (Ryr2) gene expression in rats subjected to surgery that induced HF and were subsequently treated with T4 using physiological ...
Fábio V. G. Campanha +11 more
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Consequences of Depleted SERCA2-Gated Calcium Stores in the Skin [PDF]
Journal of Investigative Dermatology, 2006 Sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) pumps belong to the family of Ca2+-ATPases responsible for the maintenance of calcium in the endoplasmic reticulum. In epidermal keratinocytes, SERCA2-controlled calcium stores are involved in cell cycle exit and onset of terminal differentiation.
Eliane J. Müller +11 more
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Phytomedicine PlusBackground: Yiqi Fumai Lyophilized Injection (YQFM) is a plant-derived preparation that shows protective effects against cardiac dysfunction in both human and animal models.
Yongwei Nie +10 more
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