Results 31 to 40 of about 10,338 (254)

Double-Stranded RNA Attenuates the Barrier Function of Human Pulmonary Artery Endothelial Cells [PDF]

, 2013
Circulating RNA may result from excessive cell damage or acute viral infection and can interact with vascular endothelial cells. Despite the obvious clinical implications associated with the presence of circulating RNA, its pathological effects on ...
A Shibamiya, A Siflinger-Birnboim, AA Birukova, AK Cardozo, Akos Heinemann, AM Lundberg, Andrea Olschewski, Attila G. Végh, B Nilius, BE Dewi, BL Jacobs, C Caspersen, C Kannemeier, C Tiruppathi, Chandran Nagaraj, Csilla Fazakas, D Torres, Diana Zabini, ET Chiang, F Aeffner, G Grynkiewicz, GM Cheng, GU Ahmmed, György Váró, Horst Olschewski, HT Ma, I Khan, I Wilhelm, Imola Wilhelm, István A. Krizbai, J Tissari, JL Harcourt, L Fischer, L Liu, M Auer-Grumbach, M Schroder, MM Szewczyk, N Pirher, NC Stowell, O Dellis, P Kumar, PR Cooper, R Malli, R Malli, R O’Callaghan, R Ross, R Sutliff, Rory Edward Morty, S Akira, S Fischer, S Fischer, S Sarkar, S Zimmer, TG Ksiazek, TM Moore, V Konya, VA Londhe, Viktoria Konya, Y Tsuji, Z Balint, Zoltán Bálint   +60 more
core   +21 more sources

SERCA2 regulates proinsulin processing and processing enzyme maturation in the pancreatic β cell [PDF]

bioRxiv, 2022
Hitoshi Iida, Tatsuyoshi Kono, Chih‐Chun Lee, Preethi Krishnan, Matthew C. Arvin, Staci A. Weaver, Timothy S. Jarvela, Robert N. Bone, Xin Tong, Peter Arvan, Iris Lindberg, Carmella Evans‐Molina   +11 more
openalex   +2 more sources

BAP31 promotes breast cancer progression by interaction with SERCA2 [PDF]

, 2023
Abstract Background B-Cell receptor-associated protein 31 (BAP31) is a resident chaperone protein in the endoplasmic reticulum. It was observed herein that a higher expression of BAP31 mRNA was associated with a worse prognosis in breast cancer patients.
Xiangtian Liu, Qiao Xu, Wenchang Qian, Haiyang Guan, Dongbo Jiang, Fazhi Yu, Qianying Guo, Mingming Wu, Xiao Zhang, Weijie Zhang, Gaopeng Li, Zhenye Yang, Zhengsheng Wu, Vijay Pandey, Xinghua Han, Xiaopeng Ma, Peter E. Lobie, Kun Yang, Tao Zhu   +18 more
openalex   +2 more sources

Spatial Transcriptional Heterogeneity in the Infarct Core and Its Surrounding Regions Targeting Piezo1 Signals in Rats With Myocardial Ischemia-Reperfusion Injury. [PDF]

MedComm (2020)
We employed spatially resolved transcriptomics to visualize and molecularly characterize the spatial distribution of gene expression profiles in the rats’ left ventricles following MIR injury. Further experiments indicated that cardiogenic Piezo1‐mediated calcium overload exacerbates MIR through the activation of matrix metalloproteinase 2‐ryanodine ...
Li Z, Jiang F, Chen Y, Li Z, Wu Y, He Z, Wu D, Xiang H.   +7 more
europepmc   +2 more sources

Mechanisms underlying local Ca²⁺ signalling differences between right and left atrial myocytes at normal and increased frequencies. [PDF]

J Physiol
Abstract figure legend Left atrial myocytes have TAT‐associated faster Ca2+ release but are more prone to maladaptation at higher frequencies due to weaker peripheral SR Ca2+ uptake and smaller trigger Ca2+ current. Abstract Changes in heart rate affect Ca2+ signalling and contractility in ventricular muscle, but the effects on atrial Ca2+ signalling ...
Kim JC, Huynh HT, Luong PK, Trinh TN, Wu Y, Grandi E, Woo SH.   +6 more
europepmc   +2 more sources

Inactivation of SERCA2 Cys674 accelerates aortic aneurysms by suppressing PPARγ [PDF]

Journal of Molecular and Cellular Cardiology, 2020
Sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) is vital to maintain intracellular calcium homeostasis. SERCA2 cysteine 674 (C674) is highly conservative and its irreversible oxidation is upregulated in human and mouse aortic aneurysms, especially in smooth muscle cells (SMCs).
Yumei Que, Xi Shu, Langtao Wang, Sai Wang, Pingping Hu, Xiaoyong Tong   +5 more
openalex   +3 more sources

Phosphorylation‐dependent Association of PDE3A1 with SERCA2 and its Regulation of SERCA2 Activity in Human Myocardium [PDF]

The FASEB Journal, 2015
PDE3 regulates cAMP‐mediated signaling in the heart. Studies in mice showed that PDE3A is associated with SERCA2, PLB and AKAP18 in a signaling complex in the SR that regulates inotropic responses. Immunohistochemical studies demonstrate that PDE3A is co‐localized in Z‐bands of human cardiomyocytes with desmin, SERCA2, PLB and AKAP18.
Faiyaz Ahmad, Weixing Shen, Fabrice Vandeput, Nicolas Szabo‐Fresnais, Judith Krall, Eva Degerman, Frank Goetz, Enno Klussmann, Matthew Movsesian, Vincent Manganiello   +9 more
openaire   +3 more sources

Cas9/AAV9-Mediated Somatic Mutagenesis Uncovered the Cell-Autonomous Role of Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2 in Murine Cardiomyocyte Maturation

Frontiers in Cell and Developmental Biology, 2022
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) is a key player in cardiomyocyte calcium handling and also a classic target in the gene therapy for heart failure.
Junsen Lin, Zhan Chen, Luzi Yang, Lei Liu, Peng Yue, Yueshen Sun, Yueshen Sun, Mingming Zhao, Xiaoling Guo, Xiaomin Hu, Xiaomin Hu, Yan Zhang, Hong Zhang, Yifei Li, Yuxuan Guo, Erdan Dong, Erdan Dong   +16 more
doaj   +1 more source

Differential Modulation of SERCA2 Isoforms by Calreticulin [PDF]

The Journal of Cell Biology, 1998
In Xenopus laevis oocytes, overexpression of calreticulin suppresses inositol 1,4,5-trisphosphate-induced Ca2+ oscillations in a manner consistent with inhibition of Ca2+ uptake into the endoplasmic reticulum. Here we report that the alternatively spliced isoforms of the sarcoendoplasmic reticulum Ca2+-ATPase (SERCA)2 gene display differential Ca2 ...
L M, John, J D, Lechleiter, P, Camacho
openaire   +2 more sources

Impact of oxidative posttranslational modifications of SERCA2 on heart failure exacerbation in young patients with non-ischemic cardiomyopathy: A pilot study

International Journal of Cardiology: Heart & Vasculature, 2020
Background: Oxidative posttranslational modifications (OPTM) impair the function of Sarcoplasmic/endoplasmic reticulum (SR) calcium (Ca2+) ATPase (SERCA) 2 and trigger cytosolic Ca2+ dysregulation. We investigated the extent of OPTM of SERCA2 in patients
Takumi Toya, Kei Ito, Kazuki Kagami, Ayumu Osaki, Atsushi Sato, Toyokazu Kimura, Shunpei Horii, Risako Yasuda, Takayuki Namba, Yasuo Ido, Yuji Nagatomo, Katsumi Hayashi, Nobuyuki Masaki, Hirotaka Yada, Takeshi Adachi   +14 more
doaj   +1 more source