Results 41 to 50 of about 10,338 (254)

Heat Shock Protein 70 Protects the Heart from Ischemia/Reperfusion Injury through Inhibition of p38 MAPK Signaling. [PDF]

, 2020
BackgroundHeat shock protein 70 (Hsp70) has been shown to exert cardioprotection. Intracellular calcium ([Ca2+]i) overload induced by p38 mitogen-activated protein kinase (p38 MAPK) activation contributes to cardiac ischemia/reperfusion (I/R) injury ...
Chen, Qing-Cai, Ji, Fu-Hai, Liu, Hong, Liu, Hua-Yue, Ma, Jiao, Meng, Xiao-Wen, Peng, Ke, Song, Nan, Song, Shao-Yong, Wang, Hui, Zhang, Juan   +10 more
core   +1 more source

Low and High Pressor Doses of Ang II Lead to Two Distinct Phenotypes of Hypertensive Heart Disease in Mice. [PDF]

APMIS
ABSTRACT Hypertension is a major contributor to cardiovascular diseases, being the most common comorbidity and the biggest risk factor in heart failure with preserved ejection fraction. Angiotensin II (Ang II) is a known hypertension and heart failure inducer in mice, but its role in the causality in phenotype development remains unclear.
Törmä D, Suoranta T, Rinta-Harri M, Hytönen J, Ylä-Herttuala S, Ruotsalainen AK.   +5 more
europepmc   +2 more sources

Cadmium Disrupted ER Ca2+ Homeostasis by Inhibiting SERCA2 Expression and Activity to Induce Apoptosis in Renal Proximal Tubular Cells

International Journal of Molecular Sciences, 2023
Cadmium (Cd2+) exposure induces chronic kidney disease and renal cancers, which originate from injury and cancerization of renal tubular cells. Previous studies have shown that Cd2+ induced cytotoxicity by disrupting the intracellular Ca2+ homeostasis ...
Kongdong Li, Chuanzhi Guo, Jiacheng Ruan, Bo Ning, C. Wong, Haifeng Shi, Jie Gu   +6 more
semanticscholar   +1 more source

Prominent heart organ-level performance deficits in a genetic model of targeted severe and progressive SERCA2 deficiency. [PDF]

PLoS ONE, 2013
The cardiac SERCA2 Ca(2+) pump is critical for maintaining normal Ca(2+) handling in the heart. Reduced SERCA2a content and blunted Ca(2+) reuptake are frequently observed in failing hearts and evidence implicates poor cardiac Ca(2+) handling in the ...
Frazer I Heinis, Kristin B Andersson, Geir Christensen, Joseph M Metzger   +3 more
doaj   +1 more source

Physical Coupling between SERCA2 and PDE3A Regulates SERCA2 Activity in Cardiomyocytes [PDF]

Biophysical Journal, 2015
Rationale: SERCA2 controls cardiac contractility, and its activity is negatively regulated by the cAMP phosphodiesterase PDE3A through an unknown mechanism. Recent clinical trials have shown upregulation of SERCA2 gene therapy as beneficial in heart failure.Objective: To examine whether PDE3A is physically associated with SERCA, and to further evaluate
openaire   +1 more source

Cardiac Plin5 interacts with SERCA2 and promotes calcium handling and cardiomyocyte contractility

Life Science Alliance, 2023
We show that elevated cardiac Plin5 correlates with up-regulation of cardiac contraction–related processes, unraveling a novel Plin5 interaction with SERCA2 associated with improved calcium handling.
M. Cinato, Ismena Mardani, Azra Miljanovic, C. Drevinge, M. Laudette, Entela Bollano, Marcus Henricsson, Johan Tolö, Marcos Bauza Thorbrügge, M. Levin, M. Lindbom, M. Arif, P. Pacher, L. Andersson, C. Olofsson, J. Borén, M. Levin   +16 more
semanticscholar   +1 more source

Characterization of Calumenin-SERCA2 Interaction in Mouse Cardiac Sarcoplasmic Reticulum [PDF]

Journal of Biological Chemistry, 2009
Calumenin is a multiple EF-hand Ca(2+)-binding protein localized in the sarcoplasmic reticulum (SR) with C-terminal SR retention signal HDEF. Recently, we showed evidence that calumenin interacts with SERCA2 in rat cardiac SR (Sahoo, S. K., and Kim, D. H. (2008) Mol. Cells 26, 265-269).
Sanjaya Kumar, Sahoo, Taeyong, Kim, Gil Bu, Kang, Jung-Gyu, Lee, Soo Hyun, Eom, Do Han, Kim   +5 more
openaire   +2 more sources

Ca2+-clock-dependent pacemaking in the sinus node is impaired in mice with a cardiac specific reduction in SERCA2 abundance

Frontiers in Physiology, 2016
Background: The sarcoplasmic reticulum Ca2+-ATPase (SERCA2) pump is an important component of the Ca2+-clock pacemaker mechanism that provides robustness and flexibility to sinus node pacemaking.
Sunil Jit Ramamoorthy Jeewanlal Logantha, Mathis Korseberg Stokke, Mathis Korseberg Stokke, Mathis Korseberg Stokke, Andrew J Atkinson, Sanjay R Kharche, Sajida eParveen, Yawer eSaeed, Ivar eSjaastad, Ivar eSjaastad, Ole M Sejersted, Ole M Sejersted, Halina eDobrzynski   +12 more
doaj   +1 more source

IgE-dependent human basophil responses are inversely associated with the sarcoplasmic reticulum Ca2+-ATPase (SERCA)

Frontiers in Immunology, 2023
Basophils crucially contribute to allergies and other Th2-driven diseases by rapidly releasing inflammatory and immunomodulatory mediators following high-affinity IgE-receptor crosslinking.
Anette T. Hansen Selnø, Vadim V. Sumbayev, Bernhard F. Gibbs, Bernhard F. Gibbs   +3 more
doaj   +1 more source

Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis. [PDF]

, 2013
Miner1 is a redox-active 2Fe2S cluster protein. Mutations in Miner1 result in Wolfram Syndrome, a metabolic disease associated with diabetes, blindness, deafness, and a shortened lifespan.
Andreyev, Alexander Y, Chen, Yi-Fan, Divakaruni, Ajit S, Dixon, Jack E, Karisch, Robert, Murphy, Anne N, Neel, Benjamin G, Perkins, Guy, Simon, Melvin I, Tsai, Ting-Fen, van der Geer, Peter, Wall, Estelle A, Wiley, Sandra E   +12 more
core   +1 more source