SERCA2 regulates proinsulin processing and processing enzyme maturation in pancreatic beta cells
Diabetologia, 2023 Increased circulating levels of incompletely processed insulin (i.e. proinsulin) are observed clinically in type 1 and type 2 diabetes. Previous studies have suggested that Ca2+ signalling within beta cells regulates insulin processing and secretion ...
Hitoshi Iida +13 more
semanticscholar +1 more source
The 4q25 variant rs13143308T links risk of atrial fibrillation to defective calcium homoeostasis [PDF]
, 2019 Aims: Single nucleotide polymorphisms on chromosome 4q25 have been associated with risk of atrial fibrillation (AF) but the exiguous knowledge of the mechanistic links between these risk variants and underlying electrophysiological alterations hampers ...
Benítez Iglesias, Raúl +9 more
core +2 more sources
Progressive Structural Defects in Canine Centronuclear Myopathy Indicate a Role for HACD1 in Maintaining Skeletal Muscle Membrane Systems [PDF]
, 2016 Mutations in HACD1/PTPLA cause recessive congenital myopathies in humans and dogs. Hydroxyacyl-coA dehydratases are required for elongation of very long chain fatty acids, and HACD1 has a role in early myogenesis, but the functions of this striated ...
Agrawal +92 more
core +3 more sources
Yulink, predicted from evolutionary analysis, is involved in cardiac function
Journal of Biomedical Science, 2021 Background The comparative evolutionary genomics analysis was used to study the functions of novel Ka/Ks-predicted human exons in a zebrafish model. The Yulink (MIOS, Entrez Gene: 54,468), a conserved gene from zebrafish to human with WD40 repeats at N ...
Ming-Wei Kuo +5 more
doaj +1 more source
SERCA is critical to control the Bowditch effect in the heart [PDF]
, 2018 The Bowditch effect or staircase phenomenon is the increment or reduction of contractile force when heart rate increases, defined as either a positive or negative staircase.
Balcazar, Dario Emmanuel +6 more
core +2 more sources
Prenatal hypoxia induces increased cardiac contractility on a background of decreased capillary density. [PDF]
, 2009 Background: Chronic hypoxia in utero (CHU) is one of the most common insults to fetal development and may be associated with poor cardiac recovery from ischaemia-reperfusion injury,yet the effects on normal cardiac mechanical performance are poorly ...
A Heintz +55 more
core +4 more sources
Beta-Adrenergic Stimulation Maintains Cardiac Function in Serca2 Knockout Mice [PDF]
Biophysical Journal, 2013 Previous studies on Serca2 knockout (KO) mice showed that cardiac function is sustained in vivo for several weeks after knockout, whereas SERCA protein levels decrease and calcium dynamics are significantly impaired. In this study, we reconcile observed cellular and organ level contractile function using a cardiac multiscale model.
Land, Sander +7 more
openaire +4 more sources
Exendin-4 Plays a Protective Role in a Rat Model of Spinal Cord Injury Through SERCA2
Cellular Physiology and Biochemistry, 2018 Background/Aims: Current therapies for spinal cord injury (SCI) have limited efficacy, and identifying a therapeutic target is a pressing need. Sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) plays an important role in regulating calcium ...
Zhonglei Sun +12 more
doaj +1 more source
A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response. [PDF]
, 2017 Insulin production by the pancreatic β-cell is required for normal glucose homeostasis. While key transcription factors that bind to the insulin promoter are known, relatively little is known about the upstream regulators of insulin transcription.
Ang, Kenny +12 more
core +1 more source
Effects of propofol pretreatment on myocardial cell apoptosis and SERCA2 expression in rats with hepatic ischemia/reperfusion [PDF]
Revista Brasileira de Anestesiologia, 2018 Introduction: Hepatic ischemia-reperfusion injury is a common pathophysiological process in liver surgery. Whether Propofol can reduce myocardial ischemia-reperfusion injury induced by hepatic ischemia-reperfusion injury in rats, together with related ...
Shuzhen Yu +9 more
doaj +6 more sources