The light and shadow of senescence and inflammation in cardiovascular pathology and regenerative medicine [PDF]
, 2017 Recent epidemiologic studies evidence a dramatic increase of cardiovascular diseases, especially associated with the aging of the world population. During aging, the progressive impairment of the cardiovascular functions results from the compromised ...
Cavarretta, Elena +9 more
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American Journal of Physiology-Heart and Circulatory Physiology, 2011 The sarco/endoplasmic reticulum (SR) Ca2+-ATPase SERCA2a has a key role in controlling cardiac contraction and relaxation. In hypothyroidism, decreased expression of the thyroid hormone (TH)-responsive SERCA2 gene contributes to slowed SR Ca2+reuptake and relaxation.
Roland, Vetter +5 more
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Calumenin Interacts with SERCA2 in Rat Cardiac Sarcoplasmic Reticulum
Molecules and Cells, 2008 Calumenin, a multiple EF-hand Ca2+ binding protein is located in the SR of mammalian heart, but the functional role of the protein in the heart is unknown. In the present study, an adenovirus gene transfer system was employed for neonatal rat heart to examine the effects of calumenin over-expression (Calu-OE) on Ca2+ transients.
Sanjaya Kumar, Sahoo, Do Han, Kim
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Cell & Bioscience, 2020 Background Arginine vasopressin (AVP) is elevated in patients with heart failure, and the increase in the AVP concentration in plasma is positively correlated with disease severity and mortality.
Jieqiong Zhao +5 more
doaj +1 more source
Low Density Lipoproteins Promote Unstable Calcium Handling Accompanied by Reduced SERCA2 and Connexin-40 Expression in Cardiomyocytes [PDF]
, 2017 The damaging effects of high plasma levels of cholesterol in the cardiovascular system are widely known, but little attention has been paid to direct effects on cardiomyocyte function.
Badimón Maestro, Lina +5 more
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Miocárdio remodelado después de grandes infartos en ratas convierte potenciación post-pausa en disminucion de la fuerza [PDF]
, 2012 BACKGROUND: Post-rest contraction (PRC) of cardiac muscle provides indirect information about the intracellular calcium handling. OBJECTIVE: Our aim was to study the behavior of PRC, and its underlying mechanisms, in rats with myocardial infarction ...
Antonio, Ednei Luiz +7 more
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Phospholamban-Independent Adrenergic Reserve in SERCA2 Ablated Hearts [PDF]
Biophysical Journal, 2015 Normal cardiac contraction and relaxation requires efficient operation of the SR Ca2+ ATPase, SERCA2a. In failing hearts, decreased SERCA2a expression and slowed SR Ca2+ reuptake are thought to significantly underlie contractile dysfunction. We have studied the relationship between decreased SERCA2a expression and cardiac function using a mouse model ...
Heinis, Frazer I., Metzger, Joseph M.
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Cardiac-specific suppression of NF-kappa B signaling prevents diabetic cardiomyopathy via inhibition of the renin-angiotensin system [PDF]
, 2014 Activation of NF-kappa B signaling in the heart may be protective or deleterious depending on the pathological context. in diabetes, the role of NF-kappa B in cardiac dysfunction has been investigated using pharmacological approaches that have a ...
Baker, Kenneth M. +9 more
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Mitochondrial transcription factors TFAM and TFB2M regulate Serca2 gene transcription [PDF]
Cardiovascular Research, 2010 Sarco(endo)plasmic reticulum Ca²(+)-ATPase 2a (SERCA2a) transports Ca²(+) by consuming ATP produced by mitochondrial respiratory chain enzymes. Messenger RNA (mRNA) for these enzymes is transcribed by mitochondrial transcription factors A (TFAM) and B2 (TFB2M).
Atai, Watanabe +7 more
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Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis. [PDF]
, 2020 Cold stimuli and the subsequent activation of β-adrenergic receptor (β-AR) potently stimulate adipose tissue thermogenesis and increase whole-body energy expenditure.
Ferro, Marc D +8 more
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