Results 71 to 80 of about 10,338 (254)

Substitution of SERCA2 Cys674 accelerates aortic aneurysm by inducing endoplasmic reticulum stress and promoting cell apoptosis

British Journal of Pharmacology, 2022
The Cys674 residue (C674) in the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) is key to maintaining its enzyme activity. The irreversible oxidation of C674 occurs broadly in aortic aneurysms.
Langtao Wang, Zhen Yang, Sai Wang, Yumei Que, X. Shu, Fuhua Wu, Gang Liu, Siqi Li, Pingping Hu, Hao Chen, Jian Shi, Xiaoyong Tong   +11 more
semanticscholar   +1 more source

Sarco/Endoplasmic Reticulum Ca²⁺ ATPase 2 Activator Ameliorates Endothelial Dysfunction; Insulin Resistance in Diabetic Mice

Cells, 2022
Background: Sarco/endoplasmic reticulum Ca2+-ATPase2 (SERCA2) is impaired in various organs in animal models of diabetes. The purpose of this study was to test the effects of an allosteric SERCA2 activator (CDN1163) on glucose intolerance ...
Toyokazu Kimura, Kazuki Kagami, Atsushi Sato, Ayumu Osaki, Kei Ito, Shunpei Horii, Takumi Toya, Nobuyuki Masaki, Risako Yasuda, Yuji Nagatomo, Takeshi Adachi   +10 more
doaj   +1 more source

Dietary Lipids Affect the Onset of Hibernation in the Garden Dormouse (Eliomys quercinus): Implications for Cardiac Function

Frontiers in Physiology, 2018
Dietary lipids strongly influence patterns of hibernation in heterotherms. Increased dietary uptake of n-6 polyunsaturated fatty acids (PUFAs), particularly of linoleic acid (LA, C18:2 n-6), enables animals to reach lower body temperatures (Tb ...
Sylvain Giroud, Gabrielle Stalder, Hanno Gerritsmann, Anna Kübber-Heiss, Jae Kwak, Walter Arnold, Thomas Ruf   +6 more
doaj   +1 more source

Functional impairment of human resident cardiac stem cells by the cardiotoxic antineoplastic agent trastuzumab [PDF]

, 2012
Trastuzumab (TZM), a monoclonal antibody against the ERBB2 protein, increases survival in ERBB2-positive breast cancer patients. Its clinical use, however, is limited by cardiotoxicity. We sought to evaluate whether TZM cardiotoxicity involves inhibition
A. c. Wolff, A. s. Barth, A. s. Ho, B. O'Rourke, CHIMENTI, ISOTTA, D. r. Davis, E. Kizana, E. Marban, G. Gerstenblith, I. Terrovitis, R. r. Smith, T. s. Li, Y. Zhang   +12 more
core   +1 more source

MicroRNAs and cardiac sarcoplasmic reticulum calcium ATPase-2 in human myocardial infarction: expression and bioinformatic analysis

BMC Genomics, 2012
Background Cardiac sarco(endo)plasmic reticulum calcium ATPase-2 (SERCA2) plays one of the central roles in myocardial contractility. Both, SERCA2 mRNA and protein are reduced in myocardial infarction (MI), but the correlation has not been always ...
Boštjančič Emanuela, Zidar Nina, Glavač Damjan   +2 more
doaj   +1 more source

Changes in the expression of cardiac genes responsive to thyroid hormones in the chickens with cold-induced pulmonary hypertension

Poultry Science, 2021
ASTRACT: Cold stress is an environmental cause of pulmonary hypertension syndrome (PHS) in broiler chickens. This factor could increase the rate of metabolic activity via thyroid hormones (T3 and T4). To evaluate the effect of these hormones on the heart,
S. Bahadoran, H. Hassanpour, S. Arab, S. Abbasnia, A. Kiani   +4 more
doaj   +1 more source

Regional ion channel gene expression heterogeneity and ventricular fibrillation dynamics in human hearts. [PDF]

, 2014
RATIONALE: Structural differences between ventricular regions may not be the sole determinant of local ventricular fibrillation (VF) dynamics and molecular remodeling may play a role.
Bignolais, O., Maguy, A., Naud, P., Nazzari, H., Sivagangabalan, G., Varró, András   +5 more
core   +1 more source

Silencing calcineurin A subunit reduces SERCA2 expression in cardiac myocytes

American Journal of Physiology-Heart and Circulatory Physiology, 2011
Resting intracellular Ca2+can be raised, in neonatal rat cardiac myocytes, by exposure to very low concentration of thapsigargin (TG). Such a Ca2+rise yields calcineurin (CN) activation demonstrated by increased expression of transfected luciferase cDNA under control of nuclear factor of activated T-cells (NFAT) promoter and increased translocation of ...
Anand Mohan, Prasad, Giuseppe, Inesi
openaire   +3 more sources

Lack of evidence for regulation of cardiac P-type ATPases and MAP kinases in transgenic mice with cardiac-specific overexpression of constitutively active α1B-adrenoceptors [PDF]

, 2010
The regulatory function of α1B-adrenoceptors in mammalian heart homeostasis is controversial. The objective of the present study was to characterize the expression/activity of key proteins implicated in cardiac calcium handling (Na+/K+-ATPase and Ca2 ...
Barreto, Frederico, Caricati-Neto, Afonso, Cunha, Valeria do Monti Nascimento, Jurkiewicz, Aron, Noël, Francois, Quintas, Luis Eduardo Menezes, Rezende, Daniele Campos, Scaramello, Christianne Bretas Vieira, Silva, Claudia Lucia Martins   +8 more
core   +2 more sources

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source