Results 81 to 90 of about 10,338 (254)

The slow sarco/endoplasmic reticulum Ca2+-ATPase declines independently of slow myosin in soleus muscle of diabetic rats [PDF]

, 2009
The sarcoplasmic reticulum Ca2+-ATPase (SERCA) isoforms are normally expressed in coordination with the corresponding myosin heavy chain (MyHC) isoforms in the fibers of skeletal muscle but this coordination is often disrupted in pathological conditions.
Rácz, Gábor, Szabó, András, Vér, Ágota, Zádor, Ernő   +3 more
core  

Sacubitril/valsartan preserves regional cardiac function following myocardial infarction in rats

ESC Heart Failure, Volume 12, Issue 2, Page 1304-1315, April 2025.
Parts of the figure were drawn by using pictures from Servier Medical Art. Servier Medical Art by Servier is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/). Abstract Aims Sacubitril/valsartan (Sac/Val) is used for treatment of heart failure. The effect of Sac/Val on regional dysfunction
Einar Sjaastad Nordén, Bård Andre Bendiksen, Kaja Knudsen Bergo, Emil Knut Stenersen Espe, Gary McGinley, Almira Hasic, Ida Marie Hauge‐Iversen, Hege Katrin Ugland, Xin Shen, Michael Frisk, Nishani S. Mabotuwana, William E. Louch, Rizwan I. Hussain, Lili Zhang, Ivar Sjaastad, Alessandro Cataliotti, Geir Christensen   +16 more
wiley   +1 more source

Substitution of the SERCA2 Cys674 reactive thiol accelerates atherosclerosis by inducing endoplasmic reticulum stress and inflammation

British Journal of Pharmacology, 2022
The cysteine674 (C674) thiol of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 is easily and irreversibly oxidized under atherosclerotic conditions. However, the contribution of the C674 thiol redox status in the development of atherosclerosis remains ...
H. Su, Y. Mei, Shuangxue Luo, Haixia Wu, Yan He, Yasumasa Shiraishi, Pingping Hu, R. Cohen, Xiaoyong Tong   +8 more
semanticscholar   +1 more source

Harnessing Free Radical Scavenging Potential of Caffeic Acid as a Nutraceutical—A Review

Food Safety and Health, EarlyView.
Caffeic acid has emerged as a promising bioactive molecule with multiple pharmacological properties, including antioxidant, antimicrobial, anti‐inflammatory, organ protective properties and metal‐chelating ability. This review emphasizes the dietary sources, structural characteristic, molecular mechanism underlying health promoting effects of caffeic ...
Pavitra Behra, Monika Bhadauria, Satendra Kumar Nirala   +2 more
wiley   +1 more source

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

Rat vas deferens SERCA2 is modulated by Ca2+/calmodulin protein kinase II-mediated phosphorylation

Brazilian Journal of Medical and Biological Research, 2013
Ca2+ pumps are important players in smooth muscle contraction. Nevertheless, little information is available about these pumps in the vas deferens. We have determined which subtype of sarco(endo)plasmic reticulum Ca2+-ATPase isoform (SERCA) is expressed ...
J.B.R. Rodriguez, H. Muzi-Filho, R.H.F. Valverde, L.E.M. Quintas, F. Noel, M. Einicker-Lamas, V.M.N. Cunha   +6 more
doaj   +3 more sources

Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling [PDF]

, 2013
Exogenous dietary fat can induce obesity and promote diabetes, but endogenous fat production is not thought to affect skeletal muscle insulin resistance, an antecedent of metabolic disease. Unexpectedly, the lipogenic enzyme fatty acid synthase (FAS) was
Aagaard, Cartee, Clay F. Semenkovich, Coupe, Haowei Song, Irfan J. Lodhi, Jensen-Urstad, Jun Yoshino, Katsuhiko Funai, Li Yin, Lodhi, Moore, Pizer, Racz, Trey Coleman, Ullman, Xiaochao Wei   +16 more
core   +2 more sources

Molecular Changes Induced by Carbon Dioxide Laser in Hailey‐Hailey Disease: A Potential Mechanism Underlying Treatment Efficacy

International Journal of Dermatology, EarlyView.
ABSTRACT Introduction Hailey‐Hailey disease (HHD) is a rare genodermatosis caused by mutations in the ATP2C1 gene that codes for SPCA1, a calcium transporter in the epidermis. HHD impairs quality of life, and no curative treatment exists. Methods To confirm the efficacy and safety of CO2 laser in HHD, we conducted a randomized, prospective, controlled ...
Javier Antoñanzas, Agustín España, Ana Gorostidi, Ana Patiño‐García, Marcos J. Araúzo‐Bravo, Daniela Gerovska, Rafael Salido‐Vallejo, Leyre Aguado‐Gil   +7 more
wiley   +1 more source

Sarcoplasmic Reticulum Calcium Release Is Required for Arrhythmogenesis in the Mouse

Frontiers in Physiology, 2021
Dysfunctional sarcoplasmic reticulum Ca2+ handling is commonly observed in heart failure, and thought to contribute to arrhythmogenesis through several mechanisms. Some time ago we developed a cardiomyocyte-specific inducible SERCA2 knockout mouse, which
Andrew G. Edwards, Andrew G. Edwards, Halvor Mørk, Mathis K. Stokke, Mathis K. Stokke, Mathis K. Stokke, David B. Lipsett, Ivar Sjaastad, Ivar Sjaastad, Sylvain Richard, Ole M. Sejersted, William E. Louch, William E. Louch   +12 more
doaj   +1 more source

The role of phospholamban (PLN) in potential protection of sarc(endo)plasmic reticulum Ca2+-ATPase (SERCA) against oxidative stress [PDF]

, 2015
Sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) sequesters Ca2+ from the cytosol to: i) aid in muscular relaxation and ii) refill SR Ca2+ stores for release upon subsequent stimulus for contraction.
Mariani, Rachelle
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