Results 121 to 130 of about 4,136 (214)

Single-shot diffraction data from the Mimivirus particle using an X-ray free-electron laser [PDF]

, 2016
Citation: Ekeberg, T., Svenda, M., Seibert, M. M., Abergel, C., Maia, F. R. N. C., Seltzer, V., . . . Hajdu, J. (2016). Single-shot diffraction data from the Mimivirus particle using an X-ray free-electron laser. Scientific Data, 3.
Abergel, C., Andersson, I., Andreasson, J., Aquila, A., Bajt, S., Barthelmess, M., Barty, A., Bogan, M. J., Bostedt, C., Bozek, J. D., Chapman, H., Claverie, J. M., Coppola, N., DePonte, D. P., Ekeberg, T., Epp, S. W., Erk, B., Fleckenstein, H., Foucar, L., Frank, M., Graafsma, H., Gumprecht, L., Hajdu, J., Hampton, C. Y., Hartmann, A., Hartmann, R., Hauser, G., Hirsemann, H., Holl, P., Iwan, B., Jonsson, O., Kassemeyer, S., Kimmel, N., Krasniqi, F., Krzywinski, J., Liang, M., Loh, N. D., Lomb, L., Maia, F. R. N. C., Martin, A. V., Messerschmidt, M., Odic, D., Reich, C., Rolles, Daniel, Rudek, B., Rudenko, Artem, Schlichting, I., Schmidt, C., Schorb, S., Seibert, M. M., Seltzer, V., Shoeman, R. L., Sierra, R. G., Soltau, H., Struder, L., Svenda, M., Ullrich, J., Weidenspointner, G., Westphal, D., Wunderer, C.   +59 more
core   +2 more sources

Synchrotron structural biology at SSRL, the beginning and beyond

Journal of Synchrotron Radiation, Volume 33, Issue 1, Page 7-17, January 2026.
It has been 50 years since the publication in PNAS of our first results on the utilization and demonstrated benefits of synchrotron radiation for macromolecular crystallography. In this brief article, I offer some personal observations and comments about that early research at Stanford and the Stanford Synchrotron Radiation Project (SSRP, later renamed
Keith Hodgson
wiley   +1 more source

Quantum Imaging with Incoherently Scattered Light from a Free-Electron Laser [PDF]

, 2017
The advent of accelerator-driven free-electron lasers (FEL) has opened new avenues for high-resolution structure determination via diffraction methods that go far beyond conventional x-ray crystallography methods.
A Aquila, A Barty, A Classen, A Singer, Adrian Benz, Anton Classen, Birgit Fischer, C Kupitz, C Thiel, Daniel Bhatti, Felix Waldmann, G Baym, Giuseppe Mercurio, Günter Brenner, HN Chapman, HN Chapman, HN Chapman, I Barke, Ivan A. Vartanyants, Ivan Zaluzhnyy, JM Slovik, Joachim von Zanthier, Jochen Wagner, JW Goodman, JW Goodman, K Ayyer, Kai Schlage, Lars Bocklage, Lukas Wenthaus, M Seibert, ND Loh, Oleg Gorobtsov, OY Gorobtsov, OY Gorobtsov, Petr Skopintsev, R Hanbury Brown, R Hanbury Brown, R Neutze, Raimund Schneider, Ralf Röhlsberger, RJ Glauber, RJ Glauber, S Oppel, Sergey Lazarev, Svenja Willing, Thomas Mehringer, W Ackermann, Wilfried Wurth, Y Takahashi, Yuri Obukhov   +49 more
core   +2 more sources

Infrared spectroscopy reveals multi-step multi-timescale photoactivation in the photoconvertible protein archetype dronpa [PDF]

, 2018
Photochromic fluorescent proteins play key roles in super-resolution microscopy and optogenetics. The light-driven structural changes that modulate the fluorescence involve both trans-to-cis isomerization and proton transfer. The mechanism, timescale and
Donaldson, Paul, Gil, Agnieszka A., Greetham, Gregory M., Hall, Christopher R., Iuliano, James N., Jones, Garth A., Laptenok, Sergey P., Lukacs, Andras, Meech, Stephen R., Miyawaki, Atsushi, Tonge, Peter J.   +10 more
core   +1 more source

Analysis strategies for time‐resolved X‐ray solution scattering at high repetition rate XFEL sources

Journal of Synchrotron Radiation, Volume 33, Issue 1, Page 18-31, January 2026.
An analysis of experimental artifacts in time‐resolved X‐ray solution scattering data acquired at high repetition rate XFEL sources, specifically at the FXE instrument at the European XFEL, is presented.With the start of the user program at the European XFEL in 2017, and more recently with the LCLS‐II upgrade, the X‐ray repetition rate at X‐ray free ...
Morten Lunn Haubro, Diana Bregenholt Zederkof, Dmitry Khakhulin, Hazem Yousef, Yifeng Jiang, Ivette Jazmin Bermudez Macias, Thomas Kluyver, Frederico Lima, Mykola Biednov, Christopher Milne, Yohei Uemura, Peter Zalden, Hao Wang, Asmus Ougaard Dohn, Kerstin Mitterer, Verena Markmann, Oliver Ohlson, Martha Tordis Wachter-Lehn, Philipp Lenzen, Benedikte Knorr Jensen, Alberte Høholdt, Tim Brandt van Driel, Amke Nimmrich, Elli Selenius, Gianluca Levi, Klaus Braagaard Møller, Martin Meedom Nielsen, Kristoffer Haldrup   +27 more
wiley   +1 more source

Towards patient‐relevant structures: reviewing body‐temperature biological macromolecules and their ligands for pharmaceutical applications

Acta Crystallographica Section D, Volume 82, Issue 1, Page 1-10, January 2026.
Regulation of pharmaceutical lead compounds does not yet involve the need for patient‐relevant macromolecular structures determined at 37°C; nevertheless, we highlight the advantages of these to ensure chemical relevance and the identification of changes which may occur under physiological conditions.
Alice Brink, John R. Helliwell, Francois J. F. Jacobs   +2 more
wiley   +1 more source

Appraising protein conformational changes by resampling time-resolved serial x-ray crystallography data

Structural Dynamics
With the development of serial crystallography at both x-ray free electron laser and synchrotron radiation sources, time-resolved x-ray crystallography is increasingly being applied to study conformational changes in macromolecules.
Adams Vallejos, Gergely Katona, Richard Neutze   +2 more
doaj   +1 more source

Development of Container Free Sample Exposure for Synchrotron X-ray Footprinting. [PDF]

, 2020
The method of X-ray footprinting and mass spectrometry (XFMS) on large protein assemblies and membrane protein samples requires high flux density to overcome the hydroxyl radical scavenging reactions produced by the buffer constituents and the total ...
Chen, Yan, DePonte, Daniel P, Gupta, Sayan, Petzold, Christopher J, Ralston, Corie Y   +4 more
core   +1 more source

Strategies for mitigating radiation damage and improving data completeness in 3D electron diffraction of protein crystals

Acta Crystallographica Section D, Volume 82, Issue 1, Page 11-22, January 2026.
This work demonstrates that multi‐position data acquisition mitigates radiation damage in electron diffraction of three‐dimensional protein crystals and that merging data from selected crystals in distinct orientations enhances completeness. Application of the two approaches enables high‐quality structural models to be obtained from limited or ...
Alaa Shaikhqasem, Farzad Hamdi, Lisa Machner, Christoph Parthier, Constanze Breithaupt, Fotis L. Kyrilis, Stephan M. Feller, Panagiotis L. Kastritis, Milton T. Stubbs   +8 more
wiley   +1 more source

Application of Micro-Tubing Reeling System to Serial Femtosecond Crystallography

Photonics
Microcrystal delivery instruments are pivotal to performing serial femtosecond crystallography experiments at the XFEL facilities. We present a novel sample delivery technique based on a micro-tubing reeling system (MRS).
Jihan Kim, Sehan Park, Yunje Cho, Jaehyun Park   +3 more
doaj   +1 more source