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Asymmetry in serial femtosecond crystallography data [PDF]
Acta Crystallographica Section A: Foundations and Advances, 2017 Serial crystallography is an increasingly important approach to protein crystallography that exploits both X-ray free-electron laser (XFEL) and synchrotron radiation. Serial crystallography recovers complete X-ray diffraction data by processing and merging diffraction images from thousands of randomly oriented non-uniform microcrystals, of which all ...
Gergely Katona +2 more
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An improved integration method in serial femtosecond crystallography
Acta Crystallographica Section D: Biological Crystallography, 2014Recent experiments in serial femtosecond crystallography (SFX) have demonstrated the feasibility of obtaining structural information from nanoscale crystals using X-ray free-electron lasers (XFELs). However, millions of crystals are required to determine one reliable structure. Here, an improved integration algorithm for SFX data processing is reported.
Kun Qu, Dong Y -H
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Serial Femtosecond Crystallography of G Protein–Coupled Receptors [PDF]
Annual Review of Biophysics, 2018 G protein–coupled receptors (GPCRs) represent a large superfamily of membrane proteins that mediate cell signaling and regulate a variety of physiological processes in the human body. Structure-function studies of this superfamily were enabled a decade ago by multiple breakthroughs in technology that included receptor stabilization, crystallization in
Benjamin Stauch, Vadim Cherezov
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Serial femtosecond crystallography: A revolution in structural biology [PDF]
Archives of Biochemistry and Biophysics, 2016 Macromolecular crystallography at synchrotron sources has proven to be the most influential method within structural biology, producing thousands of structures since its inception. While its utility has been instrumental in progressing our knowledge of structures of molecules, it suffers from limitations such as the need for large, well-diffracting ...
JOSÉ Manuel Martin Garcia +2 more
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Liquid sample delivery techniques for serial femtosecond crystallography [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2014 X-ray free-electron lasers overcome the problem of radiation damage in protein crystallography and allow structure determination from micro- and nanocrystals at room temperature. To ensure that consecutive X-ray pulses do not probe previously exposed crystals, the sample needs to be replaced with the X-ray repetition rate, which ranges from 120 Hz at ...
Uwe Weierstall
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Microcrystal delivery by pulsed liquid droplet for serial femtosecond crystallography
Acta Crystallographica Section D: Structural Biology, 2016A liquid-droplet injector has been developed that delivers pristine microcrystals to an X-ray irradiation area for conducting serial femtosecond crystallography (SFX) with an X-ray free-electron laser (XFEL). By finely tuning the pulsed liquid droplets in time and space, a high hit rate of the XFEL pulses to microcrystals in the droplets was achieved ...
Jun-Ya Kohno +2 more
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Serial Femtosecond Crystallography (SFX): An Overview
2018X-ray crystallography is a very powerful tool to determine structures of biological macromolecules at the atomic and molecular level and thereby enables insights into their function. Unfortunately, irradiating biological samples with X-rays is an inherently damaging and unavoidable process in conventional X-ray crystallography. The unique properties of
Mark S. Hunter, Petra Fromme
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Preparation of RNA Microcrystals for Serial Femtosecond Crystallography Experiments
2022Serial femtosecond crystallography (SFX) experiments using an X-ray free electron laser (XFEL) is a burgeoning method for time-resolved structural studies of biomacromolecules. As with any crystallography experiment, the most important component is quality sample preparation.
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Molecular Imaging using Serial Femtosecond Crystallography
2022Submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the Department of Chemistry & Physics, School of Molecular Sciences, La Trobe Institute for Molecular Science, College of Science, Health and Engineering, La Trobe University, Victoria.
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Implications of the focal beam profile in serial femtosecond crystallography
SPIE Proceedings, 2015The photon density profile of an X-ray free-electron laser (XFEL) beam at the focal position is a critical parameter for serial femtosecond crystallography (SFX), but is difficult to measure because of the destructive power of the beam. A novel high intensity radiation induced phasing method (HIRIP) has been proposed as a general experimental approach ...
Galli, Lorenzo +2 more
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