3D-printed sheet jet for stable megahertz liquid sample delivery at X-ray free-electron lasers [PDF]
IUCrJ, 2023 X-ray free-electron lasers (XFELs) can probe chemical and biological reactions as they unfold with unprecedented spatial and temporal resolution. A principal challenge in this pursuit involves the delivery of samples to the X-ray interaction point in ...
Patrick E. Konold +27 more
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Recent Advances and Future Perspectives on Microfluidic Mix-and-Jet Sample Delivery Devices [PDF]
Micromachines, 2021 The integration of the Gas Dynamic Virtual Nozzle (GDVN) and microfluidic technologies has proven to be a promising sample delivery solution for biomolecular imaging studies and has the potential to be transformative for a range of applications in ...
Majid Hejazian +2 more
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3D printed devices and infrastructure for liquid sample delivery at the European XFEL [PDF]
Journal of Synchrotron Radiation, 2022 The Sample Environment and Characterization (SEC) group of the European X-ray Free-Electron Laser (EuXFEL) develops sample delivery systems for the various scientific instruments, including systems for the injection of liquid samples that enable serial ...
Mohammad Vakili +20 more
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Picosecond infrared laser driven sample delivery for simultaneous liquid-phase and gas-phase electron diffraction studies [PDF]
Structural Dynamics, 2022 Here, we report on a new approach based on laser driven molecular beams that provides simultaneously nanoscale liquid droplets and gas-phase sample delivery for femtosecond electron diffraction studies.
Zhipeng Huang +3 more
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Sample delivery methods for protein X-ray crystallography with a special focus on sample consumption [PDF]
Nature CommunicationsSerial crystallography (SX) has revolutionized structural biology by enabling high-resolution structure determination for important classes of proteins, including the study of relevant biomolecular reaction mechanisms.
Abhik Manna +4 more
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Rapid sample delivery for megahertz serial crystallography at X-ray FELs [PDF]
IUCrJ, 2018 Liquid microjets are a common means of delivering protein crystals to the focus of X-ray free-electron lasers (FELs) for serial femtosecond crystallography measurements.
Max O. Wiedorn +37 more
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Helium-electrospray improves sample delivery in X-ray single-particle imaging experiments [PDF]
Scientific ReportsImaging the structure and observing the dynamics of isolated proteins using single-particle X-ray diffractive imaging (SPI) is one of the potential applications of X-ray free-electron lasers (XFELs).
Tej Varma Yenupuri +6 more
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PEO-sheathed liquid jets increase sample delivery stability for serial femtosecond X-ray crystallography [PDF]
Scientific ReportsViscoelastic jets can be generated by the polyethylene oxide (PEO) sheathing of an aqueous solution using double-flow focusing nozzles (DFFNs) and represent an efficient method to deliver samples that are dispersed in low and medium-viscosity liquids for
Mohammad Vakili +32 more
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A fixed-target platform for serial femtosecond crystallography in a hydrated environment [PDF]
IUCrJ, 2020 For serial femtosecond crystallography at X-ray free-electron lasers, which entails collection of single-pulse diffraction patterns from a constantly refreshed supply of microcrystalline sample, delivery of the sample into the X-ray beam path while ...
M. L. Shelby +15 more
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Optical kicking of liquid droplets for sample delivery in ultrafast soft X-ray experiments [PDF]
Journal of Synchrotron RadiationWe present a technique based on the optical force of a femtosecond laser acting on liquid micro-droplets for their precise manipulation in a vacuum, enabling an efficient sample delivery system for soft X-ray experiments. Conventional liquid jet methods,
Zeinab Ebrahimpour +3 more
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