Results 11 to 20 of about 2,193,169 (290)
Possibilities for serial femtosecond crystallography sample delivery at future light sources [PDF]
Structural Dynamics, 2015 Serial femtosecond crystallography (SFX) uses X-ray pulses from free-electron laser (FEL) sources that can outrun radiation damage and thereby overcome long-standing limits in the structure determination of macromolecular crystals.
L. M. G. Chavas +2 more
doaj +6 more sources
Transdermal microconduits by microscission for drug delivery and sample acquisition [PDF]
BMC Medicine, 2004 Background Painless, rapid, controlled, minimally invasive molecular transport across human skin for drug delivery and analyte acquisition is of widespread interest.
Anderson R +4 more
doaj +4 more sources
Strategies for sample delivery for femtosecond crystallography. [PDF]
Acta Crystallogr D Struct Biol, 2019 Highly efficient data-collection methods are required for successful macromolecular crystallography (MX) experiments at X-ray free-electron lasers (XFELs). XFEL beamtime is scarce, and the high peak brightness of each XFEL pulse destroys the exposed crystal volume. It is therefore necessary to combine diffraction images from a large number of crystals (
Martiel I +2 more
europepmc +7 more sources
Sample Delivery Media for Serial Crystallography. [PDF]
Int J Mol Sci, 2019 X-ray crystallographic methods can be used to visualize macromolecules at high resolution. This provides an understanding of molecular mechanisms and an insight into drug development and rational engineering of enzymes used in the industry. Although conventional synchrotron-based X-ray crystallography remains a powerful tool for understanding molecular
Nam KH.
europepmc +4 more sources
Programmed sample delivery on a pressurized paper. [PDF]
Biomicrofluidics, 2014 This paper reports a method to control the fluid flow in paper-based microfluidic devices simply by pressing over the channel surface of paper, thereby decreasing the pore size and permeability of a non-woven polypropylene sheet. As a result, fluid resistance is increased in the pressed region and causes flow rate to decrease.
Shin JH, Park J, Kim SH, Park JK.
europepmc +5 more sources
Microfluidics at Fiber Tip for Nanoliter Delivery and Sampling [PDF]
Advanced Science, 2021 AbstractDelivery and sampling nanoliter volumes of liquid can benefit new invasive surgical procedures. However, the dead volume and difficulty in generating constant pressure flow limits the use of small tubes such as capillaries. This work demonstrates sub‐millimeter microfluidic chips assembled directly on the tip of a bundle of two hydrophobic ...
Antoine Barbot +3 more
openaire +4 more sources
IUCrJ, 2023 In this commentary, we explore the pioneering implementation of 3D-printed thin liquid sheet devices for advanced X-ray scattering and spectroscopy experiments at high-repetition rate XFELs.
Martin Trebbin
doaj +1 more source
Crystal structure of CmABCB1 multi-drug exporter in lipidic mesophase revealed by LCP-SFX
IUCrJ, 2022 CmABCB1 is a Cyanidioschyzon merolae homolog of human ABCB1, a well known ATP-binding cassette (ABC) transporter responsible for multi-drug resistance in various cancers.
Dongqing Pan +11 more
doaj +1 more source
A stop-flow sample delivery system for transient spectroscopy [PDF]
Review of Scientific Instruments, 2021 A stop-flow sample delivery system for transient spectroscopy is presented, which is, in particular, suited for laser-based instruments (quantum-cascade lasers or amplified femtosecond lasers) with excitation pulse repetition rates in the range 10–100 Hz.
Buhrke, David +3 more
openaire +3 more sources
Liquid sample delivery techniques for serial femtosecond crystallography. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2014 X-ray free-electron lasers overcome the problem of radiation damage in protein crystallography and allow structure determination from micro- and nanocrystals at room temperature. To ensure that consecutive X-ray pulses do not probe previously exposed crystals, the sample needs to be replaced with the X-ray repetition rate, which ranges from 120 Hz at ...
Weierstall U.
europepmc +4 more sources