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Serial Femtosecond Crystallography (SFX): An Overview
2018X-ray crystallography is a very powerful tool to determine structures of biological macromolecules at the atomic and molecular level and thereby enables insights into their function. Unfortunately, irradiating biological samples with X-rays is an inherently damaging and unavoidable process in conventional X-ray crystallography. The unique properties of
Mark S. Hunter, Petra Fromme
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Microcrystal delivery by pulsed liquid droplet for serial femtosecond crystallography
Acta Crystallographica Section D Structural Biology, 2016A liquid-droplet injector has been developed that delivers pristine microcrystals to an X-ray irradiation area for conducting serial femtosecond crystallography (SFX) with an X-ray free-electron laser (XFEL). By finely tuning the pulsed liquid droplets in time and space, a high hit rate of the XFEL pulses to microcrystals in the droplets was achieved ...
Fumitaka, Mafuné +10 more
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Preparation of RNA Microcrystals for Serial Femtosecond Crystallography Experiments
2022Serial femtosecond crystallography (SFX) experiments using an X-ray free electron laser (XFEL) is a burgeoning method for time-resolved structural studies of biomacromolecules. As with any crystallography experiment, the most important component is quality sample preparation.
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Pathogenesis of human cytomegalovirus in the immunocompromised host
Nature Reviews Microbiology, 2021Paul D Griffiths, Matthew B Reeves
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Circulating tumour DNA — looking beyond the blood
Nature Reviews Clinical Oncology, 2022Ann Tivey, Matt Church, Natalie Cook
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Towards precision oncology with patient-derived xenografts
Nature Reviews Clinical Oncology, 2022Elena Grassi, Livio Trusolino
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Tumour heterogeneity and resistance to cancer therapies
Nature Reviews Clinical Oncology, 2017Ibiayi Dagogo-Jack
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Computationally guided discovery of thermoelectric materials
Nature Reviews Materials, 2017Prashun Gorai, Eric S Toberer
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Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research
Nature Reviews Microbiology, 2019Nicholas A Turner +2 more
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Water Determines the Structure and Dynamics of Proteins
Chemical Reviews, 2016Marie-Claire Bellissent-Funel +2 more
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