Results 181 to 190 of about 24,424 (312)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

An ESTRO-EPTN Delphi consensus on robustness evaluation in proton therapy. [PDF]

Phys Imaging Radiat Oncol
Fracchiolla F, Meijers A, Orlandi E, Korevaar E, Whitfield G, Jensen K, Hoogeman M, Wijsman R, Jouglar E, Weerd EV, Pérez JM, Rinaldi I, Garbacz-Stryszewska M, Cianchetti M, Feijoo MM, Molinelli S, Elstrøm UV, Pica A, Gosling A, Koczur B, Dahlgren CV, Alterio D, Dale E, Farid G, Compter I, Doyen J, Dale JE, Färlin J, Urbanek K, Fjæra LF, Lambrecht M, Ugland M, Tschiche M, Vidal M, Lowe M, Bütof R, Gulliford S, Comi S, Habraken S, Tessonnier T, Sterpin E, Widesott L.   +41 more
europepmc   +1 more source

Action Plan 2019-2020: Serials and Other Continuing Resources Section

, 2019
The committee’s activities have been focused in three areas: 1) Identify, share and promote best practices for open access (OA) with an emphasis on serials and continuing resources; 2) Assess existing scholarly communication metrics schemes; and 3 ...
IFLA Serials and Other Continuing Resources Section Standing Committee
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

From transmission to adaptive evolution: genomic surveillance of Getah virus. [PDF]

Front Cell Infect Microbiol
Yuan Y, Hao Y, Peng C, Zhang D, Ma W, Xiao P, Li N.   +6 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Novel Bidirectional ESD Circuit for GaN HEMT. [PDF]

Micromachines (Basel)
Zhang P, Yang C, Shen J, Luo X, Deng G, Sun S, Wei Y, Wei J.   +7 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Neural network-based aeroelastic system identification for predicting flutter of high flexibility wings. [PDF]

Sci Rep
Guo Q, Li X, Zhou Z, Ma D, Wang Y.
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source