Results 61 to 70 of about 401,736 (305)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

An advanced decision process for capacity expansion in manufacturing networks [PDF]

, 2008
Manufacturing companies develop multiple production sites for various reasons from cheaper labour to access to local markets. Expansion of capacity in such a manufacturing network is a complex decision and requires consideration of multiple factors ...
Julka, Nirupam
core  

Fourier series expansion for nonlinear Hamiltonian oscillators [PDF]

, 2010
The problem of nonlinear Hamiltonian oscillators is one of the classical questions in physics. When an analytic solution is not possible, one can resort to obtaining a numerical solution or using perturbation theory around the linear problem.
Daniel Campos, Sans, Cristina, Llopis, Isaac, Méndez López, Vicenç, Isaac Llopis, Cristina Sans, Campos, Daniel, Vicenç Méndez   +7 more
core   +1 more source

Improved Massive MIMO RZF Precoding Algorithm Based on Truncated Kapteyn Series Expansion

Information, 2019
In order to reduce the computational complexity of the inverse matrix in the regularized zero-forcing (RZF) precoding algorithm, this paper expands and approximates the inverse matrix based on the truncated Kapteyn series expansion and the corresponding ...
Xiaomei Xue, Zhengquan Li, Yongqiang Man, Song Xing, Yang Liu, Baolong Li, Qiong Wu   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Monotonicity, convexity, and Maclaurin series expansion of Qi's normalized remainder of Maclaurin series expansion with relation to cosine

Open Mathematics
In this article, the authors introduce Qi’s normalized remainder of the Maclaurin series expansion of Qi’s normalized remainder for the cosine function.
Pei Wei-Juan, Guo Bai-Ni
doaj   +1 more source

Business Retention and Expansion (BRE) Programs: Responding to Business Concerns

EDIS, 2008
FE656, a 3-page fact sheet by Henry M. Cothran, is ninth in a series on establishing Business Retention and Expansion (BRE) programs. It outlines a procedure for identifying and tracking issues identified during a business survey.
Henry M. Cothran
doaj   +1 more source

Resurgence and 1/N Expansion in Integrable Field Theories

Journal of High Energy Physics, 2021
In theories with renormalons the perturbative series is factorially divergent even after restricting to a given order in 1/N, making the 1/N expansion a natural testing ground for the theory of resurgence.
Lorenzo Di Pietro, Marcos Mariño, Giacomo Sberveglieri, Marco Serone   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source