Results 1 to 10 of about 43,203 (141)
Potential antitumoral effects of SRPK1 inhibition through modulation of VEGF splicing in pituitary somatotroph tumoral cells [PDF]
Frontiers in EndocrinologyAlternative splicing is a crucial mechanism of gene regulation that can be dysregulated in cancer. In pituitary neuroendocrine tumors (PitNETs), alteration in the serine/arginine-rich splicing factors (SRSFs) has been reported.
Donatella Treppiedi +12 more
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Neural Regeneration Research, 2023 Alternative splicing is the process of producing variably spliced mRNAs by choosing distinct combinations of splice sites within a messenger RNA precursor.
Ana M Sandoval-Castellanos +4 more
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Towards understandings of serine/arginine-rich splicing factors
Acta Pharmaceutica Sinica B, 2023 Serine/arginine-rich splicing factors (SRSFs) refer to twelve RNA-binding proteins which regulate splice site recognition and spliceosome assembly during precursor messenger RNA splicing.
Dianyang Li, Wenying Yu, Maode Lai
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iScience, 2021 Summary: Serine-arginine (SR) protein kinases (SRPKs) regulate the functions of the SR-rich splicing factors by phosphorylating multiple serines within their C-terminal arginine-serine-rich domains.
Qingyun Li +11 more
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Serine/arginine-rich splicing factors 2 (SRSF2) and SRSF4 expression patterns in Korean with colon cancer [PDF]
Korean Journal of Clinical Oncology, 2016 Purpose Splicing factors play important roles in tumorigenesis. Serine/arginine-rich splicing factors 2 (SRSF2) and SRSF4 proteins, the members of SR family proteins, are dysregulated in various cancers.
Jin-Whi Kim +6 more
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Therapeutic Targeting of Alternative Splicing: A New Frontier in Cancer Treatment
Frontiers in Oncology, 2022 The ability for cells to harness alternative splicing enables them to diversify their proteome in order to carry out complex biological functions and adapt to external and internal stimuli. The spliceosome is the multiprotein-RNA complex charged with the
Anthony J. Murphy +3 more
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Differential recruitment of pre-mRNA splicing factors to alternatively spliced transcripts in vivo. [PDF]
PLoS Biology, 2005 Alternative splicing in mammalian cells has been suggested to be largely controlled by combinatorial binding of basal splicing factors to pre-mRNA templates.
Stephen A Mabon, Tom Misteli
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BMC Plant Biology, 2022 Nearly 60 – 80 % of intron-containing plant genes undergo alternative splicing in response to either stress or plant developmental cues. RNA splicing is performed by a large ribonucleoprotein complex called the spliceosome in conjunction with associated ...
M. C. Rodriguez Gallo +3 more
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Deletion of the N-terminus of SF2/ASF permits RS-domain-independent pre-mRNA splicing. [PDF]
PLoS ONE, 2007 Serine/arginine-rich (SR) proteins are essential splicing factors with one or two RNA-recognition motifs (RRMs) and a C-terminal arginine- and serine-rich (RS) domain. SR proteins bind to exonic splicing enhancers via their RRM(s), and from this position
Stephanie D Shaw +3 more
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N6-Methyladenosine-related alternative splicing events play a role in bladder cancer
Open Life Sciences, 2022 This study investigated the role of N6-methyladenosine (m6A) and alternative splicing (AS) in bladder cancer (BLCA). The BLCA-related RNA expression profiles and AS events were downloaded from the UCSC Xena and SpliceSeq databases, respectively ...
Chang Yuan +5 more
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