Results 121 to 130 of about 43,282 (204)

SRPK Inhibitors Reduce the Phosphorylation and Translocation of SR Protein Splicing Factors, thereby Correcting BIN1, MCL-1 and BCL2 Splicing Errors and Enabling Apoptosis of Cholangiocarcinoma Cells

Frontiers in Bioscience-Scholar
Background: Cholangiocarcinoma (CCA) is a malignancy of the bile duct epithelium that is commonly found in the Thai population. CCA has poor prognosis and a low survival rate due to the lack of early diagnosis methods and the limited ...
Preenapan Changphasuk, Chaturong Inpad, Sukanya Horpaopan, Sasiprapa Khunchai, Suchada Phimsen, Damratsamon Surangkul, Tavan Janvilisri, Atit Silsirivanit, Worasak Kaewkong   +8 more
doaj   +1 more source

The many faces of SRPK1 [PDF]

, 2017
Serine-arginine protein kinase 1 (SRPK1) phosphorylates proteins involved in the regulation of several mRNA processing pathways including alternative splicing.
Bullock, Nicholas, Oltean, Sebastian
core   +2 more sources

Molecular Responses to Climate Change: How Warming and Acidification Reshape the Proteome and Phosphoproteome of the Endangered Mira Chub

Ecology and Evolution, Volume 16, Issue 3, March 2026.
ABSTRACT Global environmental change affects organisms, including their physiology. In freshwater ecosystems, where migration is limited, populations often rely on phenotypic plasticity to respond. While transcriptomics has been widely used to study stress responses at the molecular level, less is known about the proteome, which reflects post ...
João M. Moreno, Jonas Grossmann, Laura Kunz, Antje Dittmann, Vitor C. Sousa, Romana Santos   +5 more
wiley   +1 more source

A Pathway‐Based Metabolomics Approach Reveals Metabolic Strategies and Reprogramming in Drought‐Tolerant Soybean Genotypes

Legume Science, Volume 8, Issue 1, March 2026.
ABSTRACT Soybean (Glycine max) is a globally important crop, yet its productivity is highly susceptible to drought stress, particularly in rainfed systems. To better understand the biochemical basis of drought tolerance, this study employed pathway‐based metabolomics to characterize differentially expressed metabolites between drought‐tolerant and ...
Namhee Lee, Donna K. Harris, Zenglu Li, Joon Hyuk Suh   +3 more
wiley   +1 more source

Truncated serine/arginine-rich splicing factor 3 accelerates cell growth through up-regulating c-Jun expression

The Journal of Medical Investigation, 2013
Serine/arginine-rich splicing factor 3 (SRSF3), a member of the SRSF family, plays a wide-ranging role in gene expression. The human SRSF3 gene generates a major mRNA isoform encoding a functional, full-length protein and a PTC-containing isoform (SRSF3-PTC). The latter is expected to be degraded through the nonsense-mediated mRNA decay system. However,
Kano, Shizuka, Nishida, Kensei, Nishiyama, Chihiro, Akaike, Yoko, Kajita, Keisuke, Kurokawa, Ken, Masuda, Kiyoshi, Kuwano, Yuki, Tanahashi, Toshihito, Rokutan, Kazuhito   +9 more
openaire   +3 more sources

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Alternative Splicing Responses to Plant–Biotic Interactions and Abiotic Stresses in Plants

Agronomy
Alternative splicing (AS) is a crucial post-transcriptional regulatory mechanism in eukaryotes. Plants can cope with complex environmental changes through AS.
Yuxia Yao, Bo Wang, Yuna Pan, Yushi Lu, Wenjin Yu, Changxia Li   +5 more
doaj   +1 more source

Targeting Tumor Dormancy and Recurrence: Molecular Mechanisms and Peptide Therapeutic Delivery

MedComm – Oncology, Volume 5, Issue 1, March 2026.
This review summarizes the molecular mechanisms that regulate tumor dormancy and its role in cancer recurrence, with emphasis on immune evasion, extracellular matrix remodeling, metabolic regulation and angiogenic switching. It further discusses emerging peptide–based therapeutic strategies aimed at detecting, modulating, and eliminating dormant tumor ...
Abdur Raheem Aleem, Atif Ali, Wajid Ali, Yuying Cheng, Zhibin Yan, Chaoyi Xia, Chenguang Liu, Caiyun Fu, Yiren Hu, Xi Wang   +9 more
wiley   +1 more source

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

The regulation of carnitine palmitoyltransferase 1 (CPT1) mRNA splicing by nutrient availability in Drosophila fat tissue

Biochemistry and Biophysics Reports
After a meal, excess nutrients are stored within adipose tissue as triglycerides in lipid droplets. Previous genome-wide RNAi screens in Drosophila cells have identified mRNA splicing factors as being important for lipid droplet formation.
Huy G. Truong, Alexis A. Nagengast, Justin R. DiAngelo   +2 more
doaj   +1 more source