Results 131 to 140 of about 43,282 (204)

MOESM1 of Myelodysplasia-associated mutations in serine/arginine-rich splicing factor SRSF2 lead to alternative splicing of CDC25C

, 2016
Additional file 1. Supplementary information: supplemental figure legends, supplemental references, and Table S1.
Skrdlant, Lindsey, Stark, Jeremy, Ren-Jang Lin   +2 more
openaire   +1 more source

MOESM5 of Myelodysplasia-associated mutations in serine/arginine-rich splicing factor SRSF2 lead to alternative splicing of CDC25C

, 2016
Additional file 5: Figure S4. Alternative splicing of genes from a previous study using SRSF2 depletion.
Skrdlant, Lindsey, Stark, Jeremy, Ren-Jang Lin   +2 more
openaire   +1 more source

Factors affecting the expression and stability of full-length and truncated SRSF3 proteins in human cancer cells

Scientific Reports
Alternative splicing plays a crucial role in increasing the diversity of mRNAs expressed in the genome. Serine/arginine-rich splicing factor 3 (SRSF3) is responsible for regulating the alternative splicing of its own mRNA and ensuring that its expression
Sung-How Sue, Shu-Ting Liu, Shih-Ming Huang   +2 more
doaj   +1 more source

Identification and Biological Evaluation of a Novel CLK4 Inhibitor Targeting Alternative Splicing in Pancreatic Cancer Using Structure‐Based Virtual Screening

Advanced Science
Pancreatic cancer is an aggressive malignancy with a poor prognosis and limited treatment options. Cdc‐like kinase 4 (CLK4), a kinase that regulates alternative splicing by phosphorylating spliceosome components, is implicated in aberrant splicing events
Chun‐Lin Yang, Yi‐Wen Wu, Huang‐Ju Tu, Yun‐Hsuan Yeh, Tony Eight Lin, Tzu‐Ying Sung, Mu‐Chun Li, Shih‐Chung Yen, Jui‐Hua Hsieh, Ming‐Chin Yu, Sen‐Yung Hsieh, Hsing‐Pang Hsieh, Shiow‐Lin Pan, Kai‐Cheng Hsu   +13 more
doaj   +1 more source

Comprehensive systems biology analysis reveals splicing factor contributions to cutaneous melanoma progression

Scientific Reports
Cutaneous melanoma (CM) is an aggressive skin cancer with high metastatic potential and poor prognosis. Splicing factors, which regulate pre-mRNA alternative splicing (AS) events, have been suggested as potential therapeutic targets in CM.
Shuting Zhu, Rui Zhu, Yanna Wang, Junru Zhu, Yifan Zong, Liucun Zhu, Wenna Guo   +6 more
doaj   +1 more source

CENP-meta, an essential kinetochore kinesin required for the maintenance of metaphase chromosome alignment in Drosophila. [PDF]

, 2000
CENP-meta has been identified as an essential, kinesin-like motor protein in Drosophila. The 257-kD CENP-meta protein is most similar to the vertebrate kinetochore-associated kinesin-like protein CENP-E, and like CENP-E, is shown to be a component of ...
Cleveland, DW, Goldstein, LS, Marszalek, JD, McIntosh, JR, Philp, AV, Yucel, JK   +5 more
core  

Serine/arginine-rich splicing factor 7 promotes the type I interferon response by activating Irf7 transcription

Cell Reports
Tight regulation of macrophage immune gene expression is required to fight infection without risking harmful inflammation. The contribution of RNA-binding proteins (RBPs) to shaping the macrophage response to pathogens remains poorly understood. Transcriptomic analysis reveals that a member of the serine/arginine-rich (SR) family of mRNA processing ...
Haley M. Scott, Mackenzie H. Smith, Aja K. Coleman, Kaitlyn S. Armijo, Morgan J. Chapman, Summer L. Apostalo, Allison R. Wagner, Robert O. Watson, Kristin L. Patrick   +8 more
openaire   +3 more sources

A novel splice variant of the DNA-PKcs gene is associated with clinical and cellular radiosensitvity in a xeroderma pigmentosum patient [PDF]

, 2009
This article has been made available through the Brunel Open Access Publishing Fund.Background: Radiotherapy-induced DNA double strand breaks (DSB) are critical cytotoxic lesions.
Abbaszadeh, F, Arlett, CF, Bourton, EC, Clingen, PH, Green, MHL, Makarov, EM, Newbold, RF, Parris, CN, Plowman, PN, Themis, M   +9 more
core  

Targeting SRSF1 improves cancer immunotherapy by dually acting on CD8+T and tumor cells

Signal Transduction and Targeted Therapy
Serine arginine-rich splicing factor 1 (SRSF1) is a key oncogenic splicing factor in various cancers, promoting abnormal gene expression through post-translational regulation.
Gui-Qi Zhu, Zheng Tang, Tian-Hao Chu, Biao Wang, Shi-Ping Chen, Chen-Yang Tao, Jia-Liang Cai, Rui Yang, Wei-Feng Qu, Yi Wang, Qian-Fu Zhao, Run Huang, Meng-Xin Tian, Yuan Fang, Jun Gao, Xiao-Ling Wu, Jian Zhou, Wei-Ren Liu, Zhi Dai, Ying-Hong Shi, Jia Fan   +20 more
doaj   +1 more source

Serine/Arginine-Rich Splicing Factor 3 [PDF]

, 2020
openaire   +1 more source