Results 141 to 150 of about 43,282 (204)

Serine/Arginine-Rich Splicing Factor 1 [PDF]

, 2020
openaire   +1 more source

Design of a covalent protein-protein interaction inhibitor of SRPKs to suppress angiogenesis and invasion of cancer cells

Communications Chemistry
Serine–arginine (SR) proteins are splicing factors that play essential roles in both constitutive and alternative pre-mRNA splicing. Phosphorylation of their C-terminal RS domains by SR protein kinases (SRPKs) regulates their localization and diverse ...
Gongli Cai, Yishu Bao, Qingyun Li, Pang-Hung Hsu, Jiang Xia, Jacky Chi Ki Ngo   +5 more
doaj   +1 more source

Alternative Splicing in Tumorigenesis and Cancer Therapy

Biomolecules
Alternative splicing (AS) is a pivotal post-transcriptional mechanism that expands the functional diversity of the proteome by enabling a single gene to generate multiple mRNA and protein isoforms.
Huiping Chen, Jingqun Tang, Juanjuan Xiang   +2 more
doaj   +1 more source

Serine/Arginine-Rich Splicing Factor 2 [PDF]

, 2020
openaire   +1 more source

An ultra-conserved poison exon in the Tra2b gene encoding a splicing activator is essential for male fertility and meiotic cell division

The EMBO Journal
The cellular concentrations of splicing factors (SFs) are critical for controlling alternative splicing. Most serine and arginine-enriched (SR) protein SFs regulate their own concentration via a homeostatic feedback mechanism that involves regulation of ...
Caroline Dalgliesh, Saad Aldalaqan, Christian Atallah, Andrew Best, Emma Scott, Ingrid Ehrmann, George Merces, Joel Mannion, Barbora Badurova, Raveen Sandher, Ylva Illing, Brunhilde Wirth, Sara Wells, Gemma Codner, Lydia Teboul, Graham R Smith, Ann Hedley, Mary Herbert, Dirk G de Rooij, Colin Miles, Louise N Reynard, David J Elliott   +21 more
doaj   +1 more source

Targeting HASPIN kinase disrupts SR protein–mediated RNA splicing and synergizes with BCL-2 inhibitor venetoclax in AML

Blood Neoplasia
: Acute myeloid leukemia (AML) is a blood cancer complicated by acquired drug resistance, disease relapse, and low overall survival rates. Combination therapies using multiple targeted inhibitors have been effective in treating patients with AML. However,
Mengdan Liu, Ming Yan, Amanda G. Davis, Samuel A. Stoner, Edward D. Ball, Dong-Er Zhang   +5 more
doaj   +1 more source

Identification of a nuclear localization motif in the serine/arginine protein kinase PSRPK of physarum polycephalum [PDF]

, 2009
Shide Liu, Zhuolong Zhou, Ziyang Lin, Qiuling Ouyang, Jianhua Zhang, Shengli Tian, Miao Xing   +6 more
core   +1 more source

Decoding SR protein regulation: kinases, phosphatases, and therapeutic targeting strategies. [PDF]

Cell Oncol (Dordr)
Liu N, van der Ende F, van de Water B, Le Dévédec SE.   +3 more
europepmc   +1 more source

Interdependent Regulation of Alternative Splicing by Serine/Arginine-Rich and Heterogeneous Nuclear Ribonucleoprotein Splicing Factors. [PDF]

Genes (Basel)
Holmes ME, Hertel KJ.
europepmc   +1 more source

Multidimensional regulatory roles and therapeutic applications of SRSF7 in cancer. [PDF]

Cell Death Discov
Li Y, Gao H, Zhang X, Sun F, Guo Y, Qiao X.   +5 more
europepmc   +1 more source