Cell Reports, 2021 Summary: Vertebrates have evolved three paralogs, termed LUC7L, LUC7L2, and LUC7L3, of the essential yeast U1 small nuclear RNA (snRNA)-associated splicing factor Luc7p.
Noah J. Daniels +8 more
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Serine–arginine (SR)-rich splicing factors have an exon-independent function in pre-mRNA splicing [PDF]
Proceedings of the National Academy of Sciences, 1999 Two distinct functions have been proposed for the serine–arginine (SR)-rich family of splicing factors. First, SR proteins are essential splicing factors and are thought to function by mediating protein–protein interactions within the intron during spliceosome assembly.
K J, Hertel, T, Maniatis
openaire +2 more sources
Potential Antileukemia Effect and Structural Analyses of SRPK Inhibition by N-(2-(Piperidin-1-yl)-5-(Trifluoromethyl)Phenyl)Isonicotinamide (SRPIN340). [PDF]
PLoS ONE, 2015 Dysregulation of pre-mRNA splicing machinery activity has been related to the biogenesis of several diseases. The serine/arginine-rich protein kinase family (SRPKs) plays a critical role in regulating pre-mRNA splicing events through the extensive ...
Raoni Pais Siqueira +18 more
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iScience, 2021 Summary: The serine/arginine-rich (SR) family of splicing factors plays important roles in mRNA splicing activation, repression, export, stabilization, and translation.
Xiaoli Zhang +9 more
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Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells [PDF]
, 2015 Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and incurable disease. Poor prognosis is due to multiple reasons, including acquisition of resistance to gemcitabine, the first-line chemotherapeutic approach.
Bielli, P +7 more
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SRSF2 is required for mRNA splicing during spermatogenesis
BMC Biology, 2023 Background RNA splicing plays significant roles in fundamental biological activities. However, our knowledge about the roles of alternative splicing and underlying mechanisms during spermatogenesis is limited. Results Here, we report that Serine/arginine-
Wen-Long Lei +17 more
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The MKK3/6-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation [PDF]
, 2000 Individual members of the serine-arginine (SR) and heterogeneous nuclear ribonucleoprotein (hnRNP) A/B families of proteins have antagonistic effects in regulating alternative splicing.
Ben-Levy +39 more
core +2 more sources
Selective modification of alternative splicing by indole derivatives that target serine-arginine-rich protein splicing factors [PDF]
Proceedings of the National Academy of Sciences, 2005 The prevalence of alternative splicing as a target for alterations leading to human genetic disorders makes it highly relevant for therapy. Here we have usedin vitrosplicing reactions with different splicing reporter constructs to screen 4,000 chemical compounds for their ability to selectively inhibit spliceosome assembly and splicing.
Johann, Soret +12 more
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Advanced Science, 2022 Splicing of influenza A virus (IAV) RNA is an essential process in the viral life cycle that involves the co‐opting of host factors. Here, it is demonstrated that induction of host serine and arginine‐rich splicing factor 5 (SRSF5) by IAV facilitated ...
Qiuchen Li +15 more
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Regulation of splicing factors by alternative splicing and NMD is conserved between kingdoms yet evolutionarily flexible. [PDF]
, 2015 Ultraconserved elements, unusually long regions of perfect sequence identity, are found in genes encoding numerous RNA-binding proteins including arginine-serine rich (SR) splicing factors.
Brenner, Steven, Lareau, Liana
core +2 more sources