Serine/arginine-rich splicing factor 3 (SRSF3) regulates homologous recombination-mediated DNA repair [PDF]
Molecular Cancer, 2015 Our previous work found that serine/arginine-rich splicing factor 3 (SRSF3) was overexpressed in human ovarian cancer and the overexpression of SRSF3 was required for ovarian cancer cell growth and survival. The mechanism underlying the role of SRSF3 in ovarian cancer remains to be addressed.We conducted microarray analysis to profile the gene ...
He, Xiaolong, Zhang, Pei
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Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGF(delta/delta) mouse model of amyotrophic lateral sclerosis [PDF]
, 2010 Background: Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen that stimulates vasculogenesis. It has also been shown to act as a neurotrophic factor in vitro and in vivo.
Bender, F.L.P. +9 more
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Serine/arginine-rich splicing factors belong to a class of intrinsically disordered proteins [PDF]
Nucleic Acids Research, 2006 Serine/arginine-rich (SR) splicing factors play an important role in constitutive and alternative splicing as well as during several steps of RNA metabolism. Despite the wealth of functional information about SR proteins accumulated to-date, structural knowledge about the members of this family is very limited.
Haynes, Chad, Iakoucheva, Lilia M.
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Physiological and Pathological Function of Serine/Arginine-Rich Splicing Factor 4 and Related Diseases [PDF]
BioMed Research International, 2018 Serine/arginine-rich splicing factors (SRSFs) have one or two RNA recognition motifs in the N terminal and a serine/arginine-enriched domain in the C terminal. SRSFs are essential components of spliceosomes and are involved in alternative splicing, spliceosome assembly, mRNA export, and nonsense-mediated mRNA decay.
Wanyan Tan, Wei Wang, Qingfeng Ma
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Pharmacology of modulators of alternative splicing [PDF]
, 2016 More than 95% of genes in the human genome are alternatively spliced to form multiple transcripts, often encoding proteins with differing or opposing function.
Bates, DO +4 more
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SRSF1 (serine/arginine-rich splicing factor 1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on SRSF1 (serine/arginine-rich splicing factor 1), with data on DNA, on the protein encoded, and where the gene is implicated.
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Serine/Arginine–Rich Splicing Factor 3 Modulates the Alternative Splicing of Cytoplasmic Polyadenylation Element Binding Protein 2 [PDF]
Molecular Cancer Research, 2019 Abstract Triple negative breast cancer (TNBC) has an unusually low 5-year survival rate linked to higher metastatic rates. Our laboratory recently delineated a role for the alternative RNA splicing (AS) of cytoplasmic polyadenylation element binding protein 2 (CPEB2), via inclusion/exclusion of exon ...
James T. DeLigio +6 more
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Aging, 2023 As critical splicing regulators, serine/arginine-rich splicing factors (SRSFs) play pivotal roles in carcinogenesis. As dysregulation of SRSFs may confer potential cancer risks, targeting SRSFs could provide important insights into cancer therapy. However, a global and comprehensive pattern to elaborate the molecular characteristics, mechanisms, and ...
Zhang, Jinjin +2 more
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Tumor Biology, 2017 Osteopontin-c splicing isoform activates ovarian cancer progression features. Imbalanced expression of splicing factors from serine/arginine -rich and heterogeneous ribonucleoproteins families has been correlated with the generation of oncogenic splicing
Durval Santos Marques +4 more
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Identification and Regulation of Tomato Serine/Arginine-Rich Proteins Under High Temperatures
Frontiers in Plant Science, 2021 Alternative splicing is an important mechanism for the regulation of gene expression in eukaryotes during development, cell differentiation or stress response.
Remus R. E. Rosenkranz +9 more
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