Results 51 to 60 of about 43,282 (204)

Phosphorylation-mediated regulation of alternative splicing in cancer [PDF]

, 2013
Alternative splicing (AS) is one of the key processes involved in the regulation of gene expression in eukaryotic cells. AS catalyzes the removal of intronic sequences and the joining of selected exons, thus ensuring the correct processing of the primary
Naro, C, Sette, C
core   +3 more sources

A serine–arginine-rich (SR) splicing factor modulates alternative splicing of over a thousand genes in Toxoplasma gondii [PDF]

Nucleic Acids Research, 2015
Single genes are often subject to alternative splicing, which generates alternative mature mRNAs. This phenomenon is widespread in animals, and observed in over 90% of human genes. Recent data suggest it may also be common in Apicomplexa. These parasites have small genomes, and economy of DNA is evolutionarily favoured in this phylum.
Yeoh, Lee M., Goodman, Christopher D, Hall, Nathan E., van Dooren, Giel, McFadden, Geoffrey I, Ralph, Stuart A.   +5 more
openaire   +3 more sources

Depletion of the SR-related protein TbRRM1 leads to cell cycle arrest and apoptosis-like death in Trypanosoma brucei [PDF]

, 2015
Arginine-Serine (RS) domain-containing proteins are RNA binding proteins with multiple functions in RNA metabolism. In mammalian cells this group of proteins is also implicated in regulation and coordination of cell cycle and apoptosis.
Bañuelos, Carolina Paula, Levy, Gabriela Vanesa, Mendiondo, Nicolas, Moretti, Georgina, Níttolo, Analía Gabriela, Ortiz, Gastón Ezequiel, Sanchez, Daniel Oscar, Tekiel, Valeria Sonia   +7 more
core   +10 more sources

Molecular Evolution of Serine/Arginine Splicing Factors Family (SR) by Positive Selection

In Silico Biology: Journal of Biological Systems Modeling and Multi-Scale Simulation, 2006
The serine-rich (SR) protein family is involved in the pre-mRNA splicing process and the DNA sequences of the corresponding genes are highly conserved in the metazoan organisms. The mammalian SR proteins consist of one or two characteristic RNA binding domains (RBD), containing the signature sequences RDAEDA and SWQDLKD and a RS (arginine/serine-rich)
Andrés J Gutiérrez, Escobar, Aylan Farid, Arenas, Jorge Enrique, Gómez-Marin   +2 more
openaire   +2 more sources

The Role of RNA Splicing Factors in Cancer: Regulation of Viral and Human Gene Expression in Human Papillomavirus-Related Cervical Cancer

Frontiers in Cell and Developmental Biology, 2020
The spliceosomal complex components, together with the heterogeneous nuclear ribonucleoproteins (hnRNPs) and serine/arginine-rich (SR) proteins, regulate the process of constitutive and alternative splicing, the latter leading to the production of mRNA ...
Andrea Cerasuolo, Luigi Buonaguro, Franco M. Buonaguro, Maria Lina Tornesello   +3 more
doaj   +1 more source

TDP43 promotes stemness of breast cancer stem cells through CD44 variant splicing isoforms

Cell Death and Disease, 2022
Alternative splicing (AS) is a promising clinical target for cancer treatment at the post-transcriptional level. We previously identified a unique AS profile in triple-negative breast cancer (TNBC), which is regulated by the splicing regulator TAR DNA ...
Lu Guo, Hao Ke, Honglei Zhang, Li Zou, Qin Yang, Xuemei Lu, Limin Zhao, Baowei Jiao   +7 more
doaj   +1 more source

Interactome analysis brings splicing into focus [PDF]

, 2015
The spliceosome is a huge molecular machine that assembles dynamically onto its pre-mRNA substrates. A new study based on interactome analysis provides clues about how splicing-regulatory proteins modulate assembly of the spliceosome to either activate ...
Burge, Christopher B., Dominguez, Daniel
core   +2 more sources

Serine-Arginine (SR) Protein-like Factors That Antagonize Authentic SR Proteins and Regulate Alternative Splicing [PDF]

Journal of Biological Chemistry, 2001
We have characterized two RNA-binding proteins, of apparent molecular masses of approximately 40 and 35 kDa, which possess a single N-terminal RNA-recognition motif (RRM) followed by a C-terminal domain rich in serine-arginine dipeptides. Their primary structures resemble the single-RRM serine-arginine (SR) protein, SC35; however their functional ...
A E, Cowper, J F, Cáceres, A, Mayeda, G R, Screaton   +3 more
openaire   +2 more sources

The Role of Chemistry Across Disciplines From Humanities to Life Sciences in Understanding Complexity and Emergence

Angewandte Chemie, EarlyView.
This study explores the origins of life by linking prebiotic chemistry, the emergence of information‐carrying molecules such as RNA and proteins, and philosophical questions about consciousness. The study emphasizes the role of molecular evolution in the Central Dogma and provides insights into the chemical origins of biology and the basis of life's ...
Harald Schwalbe, Josef Wachtveitl, Alexander Heckel, Florian Buhr, Sabrina Toews, Thomas M. Schimmer   +5 more
wiley   +2 more sources

PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage [PDF]

, 2013
Amyotrophic lateral sclerosis (ALS) is associated with progressive degeneration of motor neurons. Several of the genes associated with this disease encode proteins involved in RNA processing, including fused-in-sarcoma/translocated-in-sarcoma (FUS/TLS ...
Adamson, Ahel, Amy Rotheray, Amé, Beli, Bertolotti, Chou, Da Cruz, Das, Dormann, Dormann, Duncan A. Q. Moore, El-Khamisy, Fernando Gómez-Herreros, Gabrielle J. Grundy, Gagné, Gardiner, Gitler, Hallier, Hanson, Hicks, Hoell, Johansson, Keith W Caldecott, Kino, Kleiman, Kleiman, Kleiman, Krietsch, Kuroda, Kwiatkowski, Lagier-Tourenne, Lagier-Tourenne, Lehtiö, Mackenzie, Majid Hafezparast, Malanga, Mastrocola, Masutani, Polo, Polymenidou, Rulten, Rulten, Ryan L. Green, Schwartz, Shieh, Stuart L. Rulten, Tan, Tan, Turner, Vance, Wang, Yang, Yang   +53 more
core   +1 more source