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Orthogonal Serine Integrases Enable Scalable Gene Storage Cascades in Bacterial Genome
ACS Synthetic BiologyGenome integration enables host organisms to stably carry heterologous DNA messages, introducing new genotypes and phenotypes for expanded applications. While several genome integration approaches have been reported, a scalable tool for DNA message storage within site-specific genome landing pads is still lacking. Here, we introduce an iterative genome
Yufei Zhang +4 more
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A diversity of serine phage integrases mediate site-specific recombination in mammalian cells
Molecular Genetics and Genomics, 2006This study evaluated the ability of five serine phage integrases, from phages A118, U153, Bxb1, phiFC1, and phiRV1, to mediate recombination in mammalian cells. Two types of recombination were investigated, including the ability of an integrase to mediate recombination between its own phage att sites in the context of a mammalian cell and the ability ...
Annahita, Keravala +6 more
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Zeitschrift für Induktive Abstammungs- und Vererbungslehre, 2021
A. Askora +3 more
semanticscholar +1 more source
A. Askora +3 more
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Structure and function of retroviral integrase
Nature Reviews Microbiology, 2021Goedele N Maertens +2 more
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Integrase inhibitors to treat HIV/Aids
Nature Reviews Drug Discovery, 2005Yves Pommier, Allison A Johnson
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[Serine-type integrases as tools for genome engineering].
Seikagaku. The Journal of Japanese Biochemical Society, 2013Nobutaka, Hirano, Mitsuru, Haruki
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Serine integrase recombinational engineering (SIRE): A versatile toolbox for genome editing
Biotechnology and Bioengineering, 2019Pieter Coussement +2 more
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Serine recombinases as tools for genome engineering
Methods, 2011William R A Brown, Margaret C M Smith
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