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Plant Genome Engineering for Targeted Improvement of Crop Traits [PDF]

Frontiers in Plant Science, 2019
To improve food security, plant biology research aims to improve crop yield and tolerance to biotic and abiotic stress, as well as increasing the nutrient contents of food. Conventional breeding systems have allowed breeders to produce improved varieties
Khalid E. M. Sedeek, Ahmed Mahas, Magdy Mahfouz   +2 more
doaj   +3 more sources

Systematic optimization of prime editing for enhanced efficiency and versatility in genome engineering across diverse cell types [PDF]

Frontiers in Cell and Developmental Biology
Prime editing offers remarkable versatility in genome editing, but its efficiency remains a major bottleneck. While continuous optimization of the prime editing enzymes and guide RNAs (pegRNAs) has improved editing outcomes, the method of delivery also ...
Huiling Mu, Huiling Mu, Yeyi Liu, Yeyi Liu, Yijia Chi, Yijia Chi, Fei Wang, Shuting Meng, Shuting Meng, Yi Zhang, Yi Zhang, Xunting Wang, Xunting Wang, Dongxin Zhao, Dongxin Zhao, Dongxin Zhao   +15 more
doaj   +2 more sources

Approaches for bacteriophage genome engineering.

Trends in Biotechnology, 2022
In recent years, bacteriophage research has been boosted by a rising interest in using phage therapy to treat antibiotic-resistant bacterial infections.
Marina Mahler, A. R. Costa, Sam P. B. van Beljouw, Peter C. Fineran, Stan J. J. Brouns   +4 more
semanticscholar   +3 more sources

Transposase-assisted target-site integration for efficient plant genome engineering. [PDF]

Nature
The current technologies to place new DNA into specific locations in plant genomes are low frequency and error-prone, and this inefficiency hampers genome-editing approaches to develop improved crops1,2.
Liu P, Panda K, Edwards SA, Swanson R, Yi H, Pandesha P, Hung YH, Klaas G, Ye X, Collins MV, Renken KN, Gilbertson LA, Veena V, Hancock CN, Slotkin RK.   +14 more
europepmc   +2 more sources

Genome engineering with targetable nucleases [PDF]

Annual Review of Biochemistry, 2014
Agricultural biotechnology; DNA editing; genome engineering; targetable nucleases; TALEN; CRISPR/cas9; DNA-targeting; mutagenesis; regulation; modern breeding ...
Carroll, Dana
core   +4 more sources

Genome engineering: writing a better genome

BioTechniques, 2012
Jeffrey M. Perkel
doaj   +2 more sources

CRISPR/Cas-Mediated Genome Engineering in Plants: Application and Prospectives [PDF]

Plants
Genetic engineering has become an essential element in developing climate-resilient crops and environmentally sustainable solutions to respond to the increasing need for global food security.
Swetaleena Mishra, Subhendu Nayak, Narendra Tuteja, Sowmya Poosapati, Durga Madhab Swain, Ranjan Kumar Sahoo   +5 more
doaj   +2 more sources

Isolation, Characterization, and Genome Engineering of a Lytic Pseudomonas aeruginosa Phage [PDF]

Microorganisms
Antibiotic-resistant bacterial infections have become one of the leading causes of human mortality. Bacteriophages presented great potential for combating antibiotic-resistant infections in the post-antibiotic era due to their high host specificity and ...
Xiaomei Cong, Shuang Zhao, Qing Zhang, Shuo Liu, Youming Zhang, Fu Yan   +5 more
doaj   +2 more sources

Porcine germline genome engineering [PDF]

Proceedings of the National Academy of Sciences, 2021
Germline editing, the process by which the genome of an individual is edited in such a way that the change is heritable, has been applied to a wide variety of animals [D. A. Sorrell, A. F. Kolb, Biotechnol. Adv. 23, 431–469 (2005); D. Baltimore et al., Science 348, 36–38 (2015)].
Luhan Yang, George Church, Hong-Ye Zhao, Lusheng Huang, Yangbin Gao, Hong-Jiang Wei, Geoffrey Yang   +6 more
openaire   +2 more sources

Enabling functional genomics with genome engineering [PDF]

Genome Research, 2015
Advances in genome engineering technologies have made the precise control over genome sequence and regulation possible across a variety of disciplines. These tools can expand our understanding of fundamental biological processes and create new opportunities for therapeutic designs.
Hilton, Isaac B., Gersbach, Charles A.
openaire   +2 more sources