Impact of CRISPR-Cas9-Based Genome Engineering in Farm Animals
Veterinary Sciences, 2021 Humans are sorely over-dependent on livestock for their daily basic need of food in the form of meat, milk, and eggs. Therefore, genetic engineering and transgenesis provide the opportunity for more significant gains and production in a short span of ...
Parul Singh, S. Ali
semanticscholar +1 more source
Modulating signaling networks by CRISPR/Cas9-mediated transposable element insertion [PDF]
, 2018 In a recent past, transposable elements (TEs) were referred to as selfish genetic components only capable of copying themselves with the aim of increasing the odds of being inherited.
A Bolotin +76 more
core +1 more source
Reference genome and comparative genome analysis for the WHO reference strain for Mycobacterium bovis BCG Danish, the present tuberculosis vaccine [PDF]
, 2019 Background: Mycobacterium bovis bacillus Calmette-Guerin (M. bovis BCG) is the only vaccine available against tuberculosis (TB). In an effort to standardize the vaccine production, three substrains, i.e. BCG Danish 1331, Tokyo 172-1 and Russia BCG-1 were
Borgers, Katlyn +9 more
core +2 more sources
Rewriting Human History and Empowering Indigenous Communities with Genome Editing Tools. [PDF]
, 2020 Appropriate empirical-based evidence and detailed theoretical considerations should be used for evolutionary explanations of phenotypic variation observed in the field of human population genetics (especially Indigenous populations). Investigators within
Fox, Keolu +2 more
core +2 more sources
Biological Parts for Kluyveromyces marxianus Synthetic Biology
Frontiers in Bioengineering and Biotechnology, 2019 Kluyveromyces marxianus is a non-conventional yeast whose physiology and metabolism lends itself to diverse biotechnological applications. While the wild-type yeast is already in use for producing fragrances and fermented products, the lack of ...
Arun S. Rajkumar +4 more
doaj +1 more source
Genome Editing in Trees: From Multiple Repair Pathways to Long-Term Stability
Frontiers in Plant Science, 2018 The CRISPR technology continues to diversify with a broadening array of applications that touch all kingdoms of life. The simplicity, versatility and species-independent nature of the CRISPR system offers researchers a previously unattainable level of ...
William Patrick Bewg +3 more
doaj +1 more source
Genomic and proteomic biases inform metabolic engineering strategies for anaerobic fungi. [PDF]
, 2020 Anaerobic fungi (Neocallimastigomycota) are emerging non-model hosts for biotechnology due to their wealth of biomass-degrading enzymes, yet tools to engineer these fungi have not yet been established.
Albà +92 more
core +1 more source
Genome editing technologies to fight infectious diseases [PDF]
, 2017 Genome editing by programmable nucleases represents a promising tool that could be exploited to develop new therapeutic strategies to fight infectious diseases.
Barzon, Luisa +2 more
core +1 more source
Universal toxin-based selection for precise genome engineering in human cells
Nature Communications, 2021 Prokaryotic restriction enzymes, recombinases and Cas proteins are powerful DNA engineering and genome editing tools. However, in many primary cell types, the efficiency of genome editing remains low, impeding the development of gene- and cell-based ...
Songyuan Li +21 more
semanticscholar +1 more source
Synthetic genome engineering gets infectious [PDF]
Proceedings of the National Academy of Sciences, 2017 Since the start of this century, a handful of research groups have pursued the synthesis and large-scale engineering of genomes. Work on synthetic genomes has seen the field scale-up from the full synthesis of the small poliovirus genome (2002) (1), to a complete working synthetic bacterial genome (2010) (2), and more recently to the construction and ...
Leslie A, Mitchell, Tom, Ellis
openaire +2 more sources