Results 181 to 190 of about 245,013 (288)

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

SERINC2-mediated serine metabolism promotes cervical cancer progression and drives T cell exhaustion. [PDF]

Int J Biol Sci
Sun Y, Zhou Y, Peng Q, Zhou W, Li X, Wang R, Yin Y, Huang H, Yao H, Li Q, Zhang X, Hu L, Jiang S, Zhang Z, Li D, Zhu X, Teng Y.   +16 more
europepmc   +1 more source

Serine and SAM Responsive Complex SESAME Regulates Histone Modification Crosstalk by Sensing Cellular Metabolism [PDF]

, 2015
Shanshan Li, Selene K. Swanson, Madelaine Gogol, Laurence Florens, Michael P. Washburn, Jerry L. Workman, Tamaki Suganuma   +6 more
openalex   +1 more source

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

Advanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen, Yahui Gao, Yulin Wang, Ting Lei, Zheng Qu, Yuhan An, Jiaxu Fu, Xin Li, Fangjun Liu, Yan Li   +9 more
wiley   +1 more source

PHGDH/SYK: a hub integrating anti-fungal immunity and serine metabolism. [PDF]

Cell Death Differ
Zhang X, Hu D, Sun X, Gu Y, Zhou Y, Su C, Liu S, Zhang C, Lu G, Wu Q, Chen A.   +10 more
europepmc   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

Time-specific study on the efficacy of stems and leaves of <i>Arachis hypogaea</i> L. targeting glycine/serine metabolism for insomnia treatment. [PDF]

J Pharm Anal
Wang Y, Huang Y, Wang G, Jiang T, Geng S, Xu H, Zhou T, Zhang W.   +7 more
europepmc   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Chemotherapy-induced macrophage CXCL7 expression drives tumor chemoresistance via the STAT1/PHGDH-serine metabolism axis and SAM paracrine feedback to M2 polarization. [PDF]

Cell Death Dis
Liu S, Gong H, Li P, Hu J, Li Y, Xu R, Cai J, Wang S, Cai J, Ma H, Mi X, Li Y, Zhou Q, Zhou Q, Yang W, Li R, Song L, Fang L.   +17 more
europepmc   +1 more source

Formation of glycine through serine-glycine biosynthesis is essential for transfer of single-carbon units to folate metabolism for early eye formation

, 2021
Justine M. Chee, Louise Lanoue, Dave Clary, KC Kent Lloyd, Ala Moshiri   +4 more
openalex   +1 more source