Results 171 to 180 of about 372,460 (343)

Different mouse mast cell populations express various combinations of at least six distinct mast cell serine proteases. [PDF]

, 1990
D S Reynolds, Richard L Stevens, W S Lane, Matthewh . Carr, K. Frank Austen, W E Serafin   +5 more
openalex   +1 more source

Phytophthora Disrupts Plant Immunity by Manipulating Nitric Oxide Homeostasis Through GSNOR Inhibition

Advanced Science, EarlyView.
Phytophthora capsici effector PcRD18 targets tomato GSNOR to disrupt NO homeostasis, promoting S‐nitrosylation of immune proteins like RBOHD. This suppresses ROS bursts and promotes pathogen infection. Mutation of the PcRD18‐binding sites of GSNOR avoids pathogen manipulation and offers a strategy to enhance crop resistance. Abstract Nitric oxide (NO),
Tingting Li, Jing Kang, Haizhu Zhang, Lina Wang, Minghui Lu, Lin Cai, Jianming Li, Matthieu H. A. J. Joosten, Yu Du   +8 more
wiley   +1 more source

Isolation, characterization, and preliminary X-ray diffraction data for a serine protease from Penicillium cyclopium.

, 1986
John Day, S. Koszelak, Duilio Cascio, A. McPherson   +3 more
openalex   +1 more source

STING COPII ER Export Trafficking and Signaling Primed by Phosphorylation Switches

Advanced Science, EarlyView.
This schematic outlines STING trafficking and signaling via coat protein II (COPII)‐mediated endoplasmic reticulum (ER) export. Following cyclic GMP‐AMP (cGAMP) stimulation, TANK‐binding kinase 1 (TBK1) activates on COPII vesicles, partially dissociating into the cytosol to phosphorylate ER‐localized STING, creating pSGME/pFS COPII‐sorting motifs ...
Yanan Nan, Dongxiao Cui, Jiajian Guo, Xiaojing Ma, Jiaming Wang, Linyue Guo, Tianyu Li, Mingrui Yang, Guangrui Huang, Anlong Xu, Wenfu Ma   +10 more
wiley   +1 more source

Genomic insights and Taguchi-based optimization of culture conditions for enhanced alkaline protease production in Streptomyces barkulensis RC1831

The Microbe
This study presents a genome analysis identifying various alkaline protease genes and culture condition optimization to enhance the production of the enzyme in Streptomyces barkulensis RC1831. The analysis of genes using bioinformatics tools such as RAST,
Pratyush Kumar Behera, Zahra Parwez, Seemon Giri, Subhransu Sekhar Behera, Suchismita Nivedita, Ananta Narayana Panda, Himadri Tanaya Behera, Lopamudra Ray   +7 more
doaj  

Cloning and characterization of the gene for an additional extracellular serine protease of Bacillus subtilis [PDF]

, 1991
Alan Sloma, G A Rufo, Kelly Theriault, M. Dwyer, Stephen W. Wilson, Janice Pero   +5 more
openalex   +1 more source

USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity

Advanced Science, EarlyView.
This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang, Shan Huang, Yan He, Weiwei Wang, Chao Tong, Mengru Ma, Manyu Zhao, Lian Yi, Klaus‐Peter Knobeloch, Peijing Zhang   +9 more
wiley   +1 more source

Thermostable serine protease inhibitor from Death cap (Amanita phalloides)

Journal of Associated Medical Sciences, 2019
Background: Protease inhibitor plays an important role in many biological processes in an organism, its selective binding toward protease potentially tuning down some specific biological processes such as enzymatic catalysis regulation, protein signaling
phichaya khamai, Ketpaillin Chimong, Kritchai Pooncharoen, Widsanusan Chartarrayawadee   +3 more
doaj  

Protease-mediated activation of Par2 elicits calcium waves during zebrafish egg activation and blastomere cleavage.

PLoS Biology
Successful initiation of animal development requires activation of the egg immediately prior to fusion of gamete pronuclei. In all taxa, this is initiated by waves of calcium transients which transverse across the egg.
Jiajia Ma, Tom J Carney
doaj   +1 more source

Computer-generated models of blood coagulation factor Xa, factor IXa, and thrombin based upon structural homology with other serine proteases.

, 1982
Bruce Furie, David H. Bing, Richard J. Feldmann, David J. Robison, John P. Burnier, B Furie   +5 more
openalex   +1 more source