Results 171 to 180 of about 358,313 (362)

Overview of the organization of protease genes in the genome of Leishmania spp

Parasites & Vectors, 2014
Background The genus Leishmania includes protozoan parasites that are able to infect an array of phlebotomine and vertebrate species. Proteases are related to the capacity of these parasites to infect and survive in their hosts and are therefore ...
Mariana Silva-Almeida, Franklin Souza-Silva, Bernardo Acácio Santini Pereira, Michelle Lopes Ribeiro-Guimarães, Carlos Roberto Alves   +4 more
doaj   +1 more source

Steric Effect in Threshold Photoionization Dissociations of Serine Conformers [PDF]

arXiv, 2008
Steric effect in the threshold dissociative ionizations of serine conformers [CH2OH-C\alphaH(NH2)-C\betaOOH] is revealed by high-level ab initio calculations combined with our newly developed infrared laser desorption / tunable VUV photoionization mass spectrometry.
arxiv  

Lipopolysaccharide‐sensitive serine‐protease zymogen (factor C) of horseshoe crab hemocytes. Identification and alignment of proteolytic fragments produced during the activation show that it is a novel type of serine protease [PDF]

, 1987
Fuminori Tokunaga, Toshiyuki Miyata, Takanori Nakamura, Takashi Morita, Kei‐ichi Kuma, Takashi Miyata, Sadaaki Iwanaga   +6 more
openalex   +1 more source

Replicating PET Hydrolytic Activity by Positioning Active Sites with Smaller Synthetic Protein Scaffolds

Advanced Science, EarlyView.
A workflow is proposed for the computational design of new‐to‐nature PET hydrolases by remodeling the protein scaffold. Starting from the functional motifs extracted from a template enzyme, designer enzymes are generated following four steps: scaffold remodeling, computational screening, experimental validation, and sequence refinement.
Yujing Ding, Shanshan Zhang, Xian Kong, Henry Hess, Yifei Zhang   +4 more
wiley   +1 more source

Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera

Advanced Science, EarlyView.
The study identified sortilin as a promising LTR, enabling targeted degradation of oncogenic proteins through an mRNA‐encoded MedTAC strategy. In a mouse model, MedTACPTK7 reduced PTK7 by up to 80%, extended survival, and showed excellent pharmacokinetics without toxicity, providing a scalable platform for targeted therapies.
Xin Chang, Xinyu Qiu, Xiaoning Tong, Shaoju Gan, Weicheng Yi, Sitao Xie, Xiangsheng Liu, Chao Zuo, Weihong Tan   +8 more
wiley   +1 more source

Sulfur mustard-stimulated proteases and their inhibitors in a cultured normal human epidermal keratinocytes model: A potential approach for anti-vesicant drug development

Toxicology Reports, 2016
Protease stimulation in cultured normal human epidermal keratinocytes (NHEK) due to sulfur mustard (SM) exposure is well documented. However, the specific protease(s) stimulated by SM and the protease substrates remain to be determined. In this study, we
Xiannu Jin, Radharaman Ray, Prabhati Ray
doaj  

Isolation and sequence analysis of serine protease cDNAs from mouse cytolytic T lymphocytes. [PDF]

, 1988
Byoung S. Kwon, Daniel P. Kestler, E Lee, Mark Wakulchik, John Ding‐E Young   +4 more
openalex   +1 more source

Endogenous Near‐Infrared Chemiluminescence: Imaging‐Guided Non‐Invasive Thrombolysis and Anti‐Inflammation Based on a Heteronuclear Transition Metal Complex

Advanced Science, EarlyView.
Cu2Ir NPs based on a Cu‐porphyrin core and cyclometalated Ir(III) substituents achieve combined endogenous peroxynitrite‐triggered NIR chemiluminescence imaging, PTT and PDT for successfully achieving safe thrombolysis, antioxidant and anti‐inflammatory multifunctionality in one single molecule.
Ziwei Wang, Bo Zhu, Wenxin Nie, Liping Zhang, Nan Xiao, Qiaohua Zhang, Zihan Wu, Chunguang Shi, Weijin Zhu, Qianwen Liu, Dongxia Zhu, Martin R. Bryce, Lijie Ren, Ben Zhong Tang   +13 more
wiley   +1 more source

Binding Selectivity Analysis from Alchemical Receptor Hopping and Swapping Free Energy Calculations [PDF]

arXiv
We present receptor hopping and receptor swapping free energy estimation protocols based on the Alchemical Transfer Method (ATM) to model the binding selectivity of a set of ligands to two arbitrary receptors. The receptor hopping protocol, where a ligand is alchemically transferred from one receptor to another in one simulation, directly yields the ...
arxiv  

Cloning, sequencing and extracellular expression of the alkaline protease gene from Bacillus stearothermophilus F1 [PDF]

, 2001
The gene of a highly thermostable alkaline protease was amplified from Bacillus stearothermophilus F1 by polymerase chain reaction using consensus primers based on the sequences of serine protease genes from related species.
Fu, Zhibiao
core