Results 181 to 190 of about 422,331 (334)

Characterization of a Serine Protease that Cleaves Pro-γ-Melanotropin at the Adrenal to Stimulate Growth [PDF]

, 2001
Andrew B. Bicknell, Khomsorn Lomthaisong, Russell J. Woods, E. Gail Hutchinson, H.P.J. Bennett, Richard T. Gladwell, Philip J. Lowry   +6 more
openalex   +1 more source

CircTspan3 Promotes Cartilage Development Through ANNEXIN A2‐Mediated Ferroptosis and Apoptosis Inhibition and Exosome‐Mediated Paracrine Signaling

Advanced Science, EarlyView.
This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan, Fengmei Zhang, Jiayan Zhong, Qian Gong, Nana Geng, Biao Kuang, Qiumei Lan, Miao Yi, Qiqi Zeng, Cheng Chen, Mengtian Fan, Chunliang Zhao, Deping Zeng, Yu Du, Mao Nie, Zhibiao Wang, Fengjin Guo   +16 more
wiley   +1 more source

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Advanced Science, EarlyView.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang, Binbin Zhao, Min Jia, Yan Zhao, Ye Lu, Wenyu Xi, Ziyu Zhu, Xiaojuan Gong, Qingyan Ma, Yuan Gao, Yijie Guo, Pan Li, Feng Zhu, Shuguang Wei, Xiancang Ma, Yunpeng Wang   +15 more
wiley   +1 more source

The roles of serine protease inhibitors in dermatoses. [PDF]

Front Genet
Xiao Z, Kang Y, Zhuo Y, Li R, Tan Y.
europepmc   +1 more source

Effectiveness of Multivitamins vs Folic Acid on Prevention of Neural Tube Defects in Mouse Genetic Models and Human Organoids

Advanced Science, EarlyView.
Folic acid (FA) and multivitamins/minerals (MVM) are recommended for the prevention of neural tube defects (NTDs). Using a novel human neural tube‐like organoid system and mouse models, the study compares the effectiveness of two supplements on NTDs and cellular behaviors.
Huili Li, Jing Zhang, Lori Bulwith, Lee Niswander   +3 more
wiley   +1 more source

PRSS38 Is a Novel Sperm Serine Protease Involved in Human and Mouse Fertilization. [PDF]

Int J Mol Sci
Manjon AA, Verón GL, Vitale R, Stegmayer G, Gonzalez Echeverria-Raffo F, Lane L, Vazquez-Levin MH.   +6 more
europepmc   +1 more source

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

Biophysical and Functional Characterization of a Thermally Stable Bifunctional Serine Protease Inhibitor from <i>Cleome viscosa</i> Seeds. [PDF]

Int J Mol Sci
Radhakrishnan M, Senthilvadivelu V, Nadendla EK, Sivashanmugan K, Krishnasamy G.   +4 more
europepmc   +1 more source

CFLIP – an Interacting Partner and a Novel Substrate for Pro-Apoptotic Serine Protease HtrA2

Kalyani Natu, Shubhankar Dutta, Kakoli Bose   +2 more
openalex   +1 more source

Differential expression of serine protease inhibitors 1 and 2 in Crassostrea corteziensis and C. virginica infected with Perkinsus marinus [PDF]

, 2014
J. N. Gutiérrez-Rivera, Guadalupe Fabiola Arcos‐Ortega, Antonio Luna‐González, Cármen Rodrı́guez-Jaramillo, Elva Teresa Aréchiga‐Carvajal, Ricardo Vázquez‐Juárez   +5 more
openalex   +1 more source