Results 181 to 190 of about 372,460 (343)

Sequence‐ and Docking‐Site‐Dependent Contributions to Multi‐Site Phosphorylation of an Intrinsically Disordered MAPK Substrate

Advanced Science, EarlyView.
Real‐time NMR spectroscopy is used to study JNK1‐dependent phosphorylation of the intrinsically disordered substrate JIP1, revealing eleven phosphosites with distinct phosphorylation efficiencies. The site‐specific phosphorylation rates are shown to be determined by both the sequence position of the phosphosites relative to the two kinase docking site ...
Thibault Orand, Elise Delaforge, Marion Chenal, Maud Tengo, Torsten Herrmann, Juan Cortés, Pau Bernadó, Malene Ringkjøbing Jensen   +7 more
wiley   +1 more source

p-Aminobenzamidine as a fluorescent probe for the active site of serine proteases.

, 1982
S. A. Evans, Steven T. Olson, Joseph D. Shore   +2 more
openalex   +1 more source

Engineered Dual‐Function Antibody‐Like Proteins to Combat SARS‐CoV‐2‐Induced Immune Dysregulation and Inflammation

Advanced Science, EarlyView.
Engineered antibody‐like proteins block the SARS‐CoV‐2 spike protein from binding to host receptors and suppress immune overactivation through an MBL‐based scaffold. These dual‐function proteins effectively alleviate inflammation, complement activation, and lung injury, offering a promising therapeutic strategy against severe COVID‐19 and its ...
Yizhuo Wang, Chenwu Bai, Kerui Hou, Zhen Zhang, Ming Guo, Xin Wang, Fan Yang, Xin Liu   +7 more
wiley   +1 more source

O‐GalNAc Glycosylation Activates MBL‐Mediated Complement and Coagulation Cascades to Drive Organotropic Metastasis

Advanced Science, EarlyView.
Upregulated glycosyltransferase GALNT9 in neuroendocrine (NE) carcinomas increases O‐GalNAc glycosylation on cell membrane proteins, particularly Annexin‐A2 (ANXA2). Elevated O‐GalNAc glycan induces the binding of NE cancer cells to mannose binding lectin 2 (MBL2), activating the MBL‐MBL associated serine protease (MBL‐MASP) complement pathway in the ...
Xinyu Chen, Wei Bao, Kaiyuan Liu, Na Jing, Genyu Du, Luyao Jiang, Qian You, Yingchao Zhang, Penghui Xu, Chaping Cheng, Nan Wang, Xialian Xi, Mingyue Wang, Yiyun Liu, Jinming Wang, Huifang Zhao, Shilei Zhang, Dinglan Wu, Chi‐Fai Ng, Jiahua Pan, Wei Xue, Wei‐Qiang Gao, Pengcheng Zhang, Kai Zhang, Helen He Zhu   +24 more
wiley   +1 more source

Evolution of Catalysis in the Serine Proteases

Cold Spring Harbor Symposia on Quantitative Biology, 1987
Charles S. Craik, Jeffrey N. Higaki, B.W. Gibson   +2 more
openaire   +3 more sources

Cloning and characterization of an extracellular temperature-labile serine protease gene fromAeromonas hydrophila [PDF]

, 1991
O Rivero, Juan Anguíta, Diana Mateos, Carmen Paniagua, Germán Naharro   +4 more
openalex   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

Hatching of whipworm eggs induced by bacterial contact is serine-protease dependent. [PDF]

PLoS Pathog
Goulding D, Tolley C, Mkandawire TT, Doyle SR, Hart E, Airs PM, Grencis RK, Berriman M, Duque-Correa MA.   +8 more
europepmc   +2 more sources

Crystallographic refinement by incorporation of molecular dynamics: thermostable serine protease thermitase complexed with eglin c

, 1989
Piet Gros, M. Fujinaga, B.W. Dijkstra, K.H. Kalk, Wim G. J. Hol   +4 more
openalex   +1 more source

Analysis of proteins binding to the proximal promoter region of two rat serine protease inhibitor genes [PDF]

, 1992
Valérie Rossi, Jean François ROUAYRENC, Laurent Paquereau, Marie Joseé Vilarem, Alphonse Le Cam   +4 more
openalex   +1 more source