Results 221 to 230 of about 372,460 (343)

Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies

Annals of Neurology, EarlyView.
Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical, and genetic disease mechanisms with a resulting emphasis on ...
Brent L. Fogel, Thomas Klopstock, David R. Lynch, Francesca Maltecca, Mayank Verma, Berge A. Minassian, Frances M. Platt, Débora Farina Gonçalves, Hélène Puccio, Andreas Roos, Matthis Synofzik   +10 more
wiley   +1 more source

Monoclonal antibody neutralizes <i>Staphylococcus aureus</i> serine protease-like protein B (SplB)-induced pathology. [PDF]

Infect Immun
Iqbal J, von Fournier J, Wittmann N, Darisipudi MN, Mrochen DM, Smiljanov B, Surmann K, Wockenfuß G, Steil L, Kohler TP, Glinka FL, Peringathara S, Saade C, Fernandes LM, Bornscheuer U, Reichel CA, Bröker BM, Raafat D, Holtfreter S.   +18 more
europepmc   +1 more source

cis-Acting elements controlling transcription from rat serine protease inhibitor 2.1 gene promoter. Characterization of two growth hormone response sites and a dominant purine-rich element.

, 1994
A Le Cam, V. Pantescu, Laurent Paquereau, Catherine Legraverend, G. Fauconnier, Guillermina Asins   +5 more
openalex   +1 more source

Endogenous Serine Protease Inhibitor Modulates Epileptic Activity and Hippocampal Long-Term Potentiation [PDF]

, 1997
Andreas Lüthi, Herman van der Putten, Florence Botteri, Isabelle M. Mansuy, Marita Meins, Uwe Frey, Gilles Sansig, C. Portet, Markus Schmutz, Markus Schröder, Cordula Nitsch, Jean-Paul Laurent, Denis Monard   +12 more
openalex   +1 more source

Developing HaloTag and SNAP‐Tag Chemical Inducers of Dimerization to Probe Receptor Oligomerization and Downstream Signaling

Angewandte Chemie International Edition, Accepted Article.
Controlling protein‐protein interactions is critical for dissecting signaling pathways, especially those initiated by ligand‐receptor interactions which alter receptor oligomerization and drive downstream signaling cascades. Traditional methods for driving protein‐protein complexes are using antibodies that face limitations in terms of stoichiometry ...
Johannes Broichhagen, Michael Trumpp, Blaise Gatin-Fraudet, Kjell Bruckmann, Wiktor Burdzinski, Kilian Roßmann, Joshua Levitz, Petra Knaus, Jerome Jatzlau   +8 more
wiley   +1 more source

Comparison of structures and inhibition activities of serine protease inhibitors of Trichinella spiralis and Trichinella pseudospiralis. [PDF]

Cell Biosci
Li R, Zhang B, Chen C.
europepmc   +1 more source

The substrate specificity of Uca pugilator collagenolytic serine protease 1 correlates with the bovine type I collagen cleavage sites.

, 1994
Christopher Tsu, John J. Perona, Volker Schellenberger, Christoph W. Turck, Charles S. Craik   +4 more
openalex   +1 more source

Sequence, Purification, and Cloning of an Intracellular Serine Protease, Quiescent Cell Proline Dipeptidase [PDF]

, 1999
Robert Underwood, Murali Chiravuri, Henry Lee, Tracy L. Schmitz, Alisa K. Kabcenell, Kurt Yardley, Brigitte T. Huber   +6 more
openalex   +1 more source

Redirecting the Peptide Cleavage Causes Protease Inactivation

Angewandte Chemie International Edition, EarlyView.
Cysteine proteases catalyze substrate cleavage by a two‐step acyl transfer mechanism. Newly designed peptidic inhibitors of human cathepsin B with N‐terminal carbamate warheads undergo a redirected cleavage and generate non‐canonical covalent complexes.
Christian Breuer, Jim Küppers, Anna‐Christina Schulz‐Fincke, Anna Heilos, Carina Lemke, Petra Spiwoková, Janina Schmitz, Laura Cremer, Marta Frigolé‐Vivas, Michael Lülsdorff, Matthias D. Mertens, Filip Wichterle, Miloš Apeltauer, Martin Horn, Erik Gilberg, Norbert Furtmann, Jürgen Bajorath, Ulrike Bartz, Bernd Engels, Michael Mareš, Michael Gütschow   +20 more
wiley   +1 more source

Evidence that HetR protein is an unusual serine-type protease [PDF]

, 1998
Ruanbao Zhou, Xingcheng Wei, Nan Jiang, Huiguang Li, Yuqing Dong, Kuo-L. Hsi, Jindong Zhao   +6 more
openalex   +1 more source