Results 221 to 230 of about 265,042 (263)
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The novel inhibitors of serine proteases
Amino Acids, 2009Thirty optically active nonprotein alpha-amino acids and peptides based thereon have been screened for their ability to interact with bovine trypsin and proteinase K from Tritirachium album Limber, which belong to the group of serine proteases. Both structure-based drug design approach and determination of enzyme activity have been used to identify low
N, Hovhannisyan +7 more
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Serine proteases of the complement system
Biochemical Society Transactions, 2000The complement system in blood plasma is a major mediator of innate immune defence. The function of complement is to recognize, then opsonize or lyse, particulate materials, including bacteria, yeasts and other microrganisms, host cell debris and altered host cells.
R B, Sim, A, Laich
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Targeting Serine Proteases in Asthma
Current Topics in Medicinal Chemistry, 2006Leukocytes and lung structural cells contribute to the pathophysiology of asthma through the production of numerous mediators including serine proteases. Such proteases include mast cell tryptase and chymase; neutrophil elastase, cathepsin G and myeloblastin (proteinase 3); bronchial epithelial cell-derived transmembrane protease, serine 11D (human ...
Caroline, Guay +2 more
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Serpins (Serine Protease Inhibitors)
Current Protocols in Protein Science, 2001AbstractSerpins are a class of proteins involved in the regulation of serine and other types of proteases. In humans, the majority of serpins regulate the functions of proteases involved in the body's response to injury. This includes roles in coagulation, fibrinolysis, inflammation, wound healing, and tissue repair.
Susannah J, Bauman +2 more
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Rare Disease and Orphan Drugs Journal, 2023
The identification and characterization of the four active neutrophil serine proteases (NSPs) have provided a better understanding of their roles in various physiological and pathological processes. The availability of appropriate tools such as substrates, inhibitors, and activity-based probes (ABPs) for studying their activity and functions in cells ...
Marcin Skoreński +2 more
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The identification and characterization of the four active neutrophil serine proteases (NSPs) have provided a better understanding of their roles in various physiological and pathological processes. The availability of appropriate tools such as substrates, inhibitors, and activity-based probes (ABPs) for studying their activity and functions in cells ...
Marcin Skoreński +2 more
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Novel Serine Protease Inhibitors
Pharmaceutical Patent Analyst, 2012The pursuit of serine protease inhibitors as anticoagulants and anti-hepatitis C virus drugs continues to be an active area of research. Compounds such as P1-P3 macrocyclic peptides and linear peptides have been registered as potent hepatitis C virus protease inhibitors and compounds such as phenylglycinamide derivatives, substituted biaryls ...
Anilkumar R, Kore +1 more
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Serine protease inhibitors (serpins)
Trends in Cardiovascular Medicine, 1991Inhibition of serine proteases by serpins (serpin: serine protease inhibitor) is a key mechanism for the control of proteolysis in thrombosis, shock, and inflammation. The various members of the serpin gene superfamily (α(1)-antitrypsin, ovalbumin, C1-inhibitor, antithrombin III, α(2)-antiplasmin, type-1 plasminogen-activator inhibitor, and so forth ...
M, Schapira, P A, Patston
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On the stereochemistry of catalysis by serine proteases
Journal of Theoretical Biology, 1974Abstract From stereochemical considerations and model building the following conclusions were drawn for the stereochemistry of the catalytic steps of chymotrypsin and subtilisin. (1) In contrast to previous stereochemical investigations, rotation of 120° or more of the oxygen atom of the “reactive” serine residue is not possible in the course of the ...
L, Polgár, B, Asbóth
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The modular serine proteases of the complement cascade
Current Opinion in Structural Biology, 2012Modular serine proteases are central to the complement cascade of the mammalian humoral immune system. These proteases form protein complexes through multi-domain interactions to achieve their proteolytic activity. We review the structural insights into complement initiation by auto-activation of the hetero-tetrameric proteases of the large danger ...
FORNERIS, FEDERICO, Jin Wu, Piet Gros
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Coumarin and Isocoumarin as Serine Protease Inhibitors
Current Pharmaceutical Design, 2004Serine proteases are attractive targets for the design of enzyme inhibitors since they are involved in the etiology of several diseases. Within the class of serine proteases, HLE is one of the most destructive enzymes in the body. It is implicated in the promotion or exacerbation of a number of diseases including pancreatitis, acute respiratory ...
Pochet, L. +2 more
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