Results 341 to 350 of about 358,313 (362)

Hydrolysis of polyesters by serine proteases

Biotechnology Letters, 2005
The substrate specificity of alpha-chymotrypsin and other serine proteases, trypsin, elastase, proteinase K and subtilisin, towards hydrolysis of various polyesters was examined using poly(L-lactide) (PLA), poly(beta-hydroxybutyrate) (PHB), poly(ethylene succinate) (PES), poly(ethylene adipate) (PEA), poly(butylene succinate) (PBS), poly(butylene ...
Yutaka Tokiwa, Hyun-A. Lim, Takao Raku
openaire   +3 more sources

Inhibition of serine proteases by steroids

Biochemical Pharmacology, 1982
Proteolysis of 14C-labeled globin, as well as the hydrolysis of the specific substrate benzoyl tyrosine ethyl ester, by purified bovine chymotrypsin was found to be inhibited by several steroid hormones. The inhibition of chymotrypsin by the steroids was of a competitive nature, with Ki values of 9.9 x 10(-5) M for triamcinolone (9-fluoro-11 beta, 16 ...
Bilha Neufeld, Michael Mayer, Zvezdana Finci   +2 more
openaire   +3 more sources

Serine Protease Mechanism and Specificity

ChemInform, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire   +4 more sources

Serine protease inhibitors (serpins)

Trends in Cardiovascular Medicine, 1991
Inhibition of serine proteases by serpins (serpin: serine protease inhibitor) is a key mechanism for the control of proteolysis in thrombosis, shock, and inflammation. The various members of the serpin gene superfamily (α(1)-antitrypsin, ovalbumin, C1-inhibitor, antithrombin III, α(2)-antiplasmin, type-1 plasminogen-activator inhibitor, and so forth ...
Philip A. Patston, Marc Schapira
openaire   +3 more sources

Strategies for the inhibition of serine proteases

Cellular and Molecular Life Sciences, 2001
Serine proteases have been shown to play a multifarious role in health and disease. As a result, there has been considerable interest in the design and development of synthetic inhibitors of these enzymes. In view of their diverse roles in biological processing events, one of the great challenges in such endeavours has been the need to produce ...
Brian Walker, John F. Lynas
openaire   +3 more sources

Serine proteases and cardiac function

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2005
The serine proteases of the trypsin superfamily are versatile enzymes involved in a variety of biological processes. In the cardiovascular system, the importance of these enzymes in blood coagulation, platelet activation, fibrinolysis, and thrombosis has been well established.
Gary Gang Deng, Hai-Chien Kuo, Qingyu Wu
openaire   +2 more sources

Serpins (Serine Protease Inhibitors)

Current Protocols in Protein Science, 2001
AbstractSerpins are a class of proteins involved in the regulation of serine and other types of proteases. In humans, the majority of serpins regulate the functions of proteases involved in the body's response to injury. This includes roles in coagulation, fibrinolysis, inflammation, wound healing, and tissue repair.
Susannah J. Bauman, Frank C. Church, Herbert C. Whinna   +2 more
openaire   +3 more sources

The modular serine proteases of the complement cascade

Current Opinion in Structural Biology, 2012
Modular serine proteases are central to the complement cascade of the mammalian humoral immune system. These proteases form protein complexes through multi-domain interactions to achieve their proteolytic activity. We review the structural insights into complement initiation by auto-activation of the hetero-tetrameric proteases of the large danger ...
FORNERIS, FEDERICO, Jin Wu, Piet Gros
openaire   +5 more sources

Serine Proteases in Bone Disease

Current Rheumatology Reviews, 2009
Serine proteases are active in many physiological and pathological processes within bone tissue. Although essential to adequate maintenance of bone and cartilage, their inappropriate expression can lead to exacerbation of tissue destruction and inflammation.
Bouteldja, N., Timson, D.J.
openaire   +3 more sources

Coumarin and Isocoumarin as Serine Protease Inhibitors

Current Pharmaceutical Design, 2004
Serine proteases are attractive targets for the design of enzyme inhibitors since they are involved in the etiology of several diseases. Within the class of serine proteases, HLE is one of the most destructive enzymes in the body. It is implicated in the promotion or exacerbation of a number of diseases including pancreatitis, acute respiratory ...
Bernard Masereel, Lionel Pochet, Raphaël Frédérick   +2 more
openaire   +3 more sources