Communications Biology, 2020 Peterle et al. show that a subtilisin like serine protease secreted from gut microbiota Bacillus subtilis cleaves the wild-type human transthyretin (hTTR) to generate an amyloidogenic peptide.
Daniele Peterle +10 more
doaj +1 more source
Design and synthesis of a potential inhibitor for DEN2 NS2B/NS3 serine protease / Lee Yean Kee [PDF]
, 2011 This work involves searching and designing of inhibitors for DEN2 NS2B/NS3 serine protease. It comprises three phases: modeling, synthesis and screening.
Lee, Yean Kee
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S9 protease WprP2 catalyzes uniform cleavage on the precursor peptide in RiPP biosynthesis
Communications ChemistrySerine proteases in ribosomally synthesized and post-translationally modified peptides (RiPPs) catalyze the cleavage on the precursor peptides in the biosynthesis of RiPP natural products. Here, we identified an uncharacterized serine protease WprP2 from
Jabal Rahmat Haedar +4 more
doaj +1 more source
Molecular characterization of Vibrio harveyi virulence associated serine protease and outer membrane protein genes for vaccine development [PDF]
, 2016 Vibrio harveyi is the most pathogenic species associated with the infection in a wide range of marine species in aquaculture industries. A few virulence-associated genes have been discovered in V. harveyi.
Md Yasin, Ina Salwany +4 more
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The serine protease homolog spheroide is involved in sensing of pathogenic Gram-positive bacteria. [PDF]
PLoS ONE, 2017 In Drosophila, recognition of pathogens such as Gram-positive bacteria and fungi triggers the activation of proteolytic cascades and the subsequent activation of the Toll pathway.
Jelena Patrnogic, Vincent Leclerc
doaj +1 more source
Purification and recovery of serine protease from mango (Mangifera indica cv. Chokanan) waste using aqueous two-phase system: potential low cost of enzyme and purification method [PDF]
, 2013 Serine proteases are one of the most important groups of protease enzymes which have been used widely in different types of industries and biotechnological applications. Plant peel could be a potential source of proteases due to easy purification methods,
Abdul Manap, Mohd Yazid, Mehrnoush, Amid
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Toxicology Reports, 2016 Protease stimulation in cultured normal human epidermal keratinocytes (NHEK) due to sulfur mustard (SM) exposure is well documented. However, the specific protease(s) stimulated by SM and the protease substrates remain to be determined. In this study, we
Xiannu Jin, Radharaman Ray, Prabhati Ray
doaj +1 more source
Rational design of serine protease inhibitors [PDF]
, 2011 Proteases regulate a spectrum of diverse physiological processes, and dysregulation of proteolytic activity drives a plethora of pathological conditions.
Swedberg, Joakim Erik
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Plasmin Inhibitors Prevent Leukocyte Accumulation and Remodeling Events in the Postischemic Microvasculature [PDF]
, 2011 Clinical trials revealed beneficial effects of the broad-spectrum serine protease inhibitor aprotinin on the prevention of ischemia-reperfusion (I/R) injury. The underlying mechanisms remained largely unclear.
Nina Berberich +33 more
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Identification of Myofibril‒bound Serine Protease from Red Seabream（Pagrus major）Ordinary Muscle [PDF]
, 2019 Myofibrillar proteins were prepared from red seabream (Pagrus major) ordinary muscle by washing four times to remove sarcoplasmic proteins. Myosin heavy chain (MHC) of the myofibrillar proteins was degraded at 55℃ without the addition of any protease ...
オオクボ, マコト +19 more
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