Results 71 to 80 of about 491,498 (207)

Isolation, Identification, and Characterization of a Serine Protease with Anti-nociceptive Activity from the Gut Bacterium, Faecalibacterium prausnitzii [PDF]

Inflammatory bowel disease (IBD) induces hyperexcitability in dorsal root ganglion (DRG) nociceptors, which contributes to abdominal pain. Proteases modulate the excitability of nociceptive neurons via activation of cell-surface protease-activated ...
Taylor, Alward, Prameet, Sheth, Josh, Innis, Lorena, Ucciferri, Manasa, Ramachandra, Shu-Mei, He, Alan, Lomax, Corey, Baker, Avena, Ross   +8 more
core   +2 more sources

TMPRSS2 (transmembrane protease, serine 2) [PDF]

, 2010
Review on TMPRSS2 (transmembrane protease, serine 2), with data on DNA, on the protein encoded, and where the gene is ...
Y Park, Park, Y
core   +1 more source

The GB virus C (GBV-C) NS3 serine protease inhibits HIV-1 replication in a CD4+ T lymphocyte cell line without decreasing HIV receptor expression.

PLoS ONE, 2012
IntroductionPersistent infection with GBV-C (GB Virus C), a non-pathogenic virus related to hepatitis C virus (HCV), prolongs survival in HIV infection. Two GBV-C proteins, NS5A and E2, have been shown previously to inhibit HIV replication in vitro.
Sarah L George, Dino Varmaz, John E Tavis, Adnan Chowdhury   +3 more
doaj   +1 more source

Enterohemorrhagic E. coli (EHEC)—Secreted Serine Protease EspP Stimulates Electrogenic Ion Transport in Human Colonoid Monolayers

Toxins, 2018
One of the characteristic manifestations of Shiga-toxin-producing Escherichia coli (E. coli) infection in humans, including EHEC and Enteroaggregative E. coli O104:H4, is watery diarrhea. However, neither Shiga toxin nor numerous components of the type-3
C. Ming Tse, Julie G. In, Jianyi Yin, Mark Donowitz, Michele Doucet, Jennifer Foulke-Abel, Fernando Ruiz-Perez, James P. Nataro, Nicholas C. Zachos, James B. Kaper, Olga Kovbasnjuk   +10 more
doaj   +1 more source

The purification and characterisation of novel dipeptidyl peptidase IV-like activity from bovine serum [PDF]

, 2004
The discovery of a potentially novel proline-specific peptidase from bovine serum is presented which is capable of cleaving the dipeptidyl peptidase IV (DPIV) substrate Gly-Pro-MCA.
Buckley, Seamus J., O'Connor, Brendan, O\u27Connor, Brendan, Collins, Patrick   +3 more
core   +2 more sources

Identification of the fusobacterial serine protease.

, 2014
Amino acid sequences of the putative serine protease open reading frames FN1426 (Fsp25586) (A), and FNV0835 (Fsp49256) (B). Red highlight indicates sequences identified by mass spectrometry of the 99 kDa serine protease of F.
Yara Ibrahim (651781), Gilad Bachrach (116639), Graciela Rosen (651784), Amir Eini (651782), Ronit Naor (651783), Shunit Coppenhagen-Glazer (651780), Lior Doron (651779)   +6 more
core   +1 more source

Prostasin is a glycosylphosphatidylinositol-anchored active serine protease [PDF]

, 2001
A recombinant human prostasin serine protease was expressed in several human cell lines. Subcellular fractionation showed that this serine protease is synthesized as a membrane-bound protein while a free-form prostasin is secreted into the culture medium,
Chao, Lee, Chai, Karl X., Chen, Li-Mei, Skinner, Melanie L., Kauffman, Steven W., Thaler, Catherine D., Chao, Julie   +6 more
core   +1 more source

Involvement of cathepsin B in the plant disease resistance hypersensitive response [PDF]

, 2007
A diverse range of plant proteases are implicated in pathogen perception and in subsequent signalling and execution of disease resistance. We demonstrate, using protease inhibitors and virus-induced gene silencing (VIGS), that the plant papain cysteine ...
Shaw, Jane, Hein, I., Christophe Lacomme, Kaffarnik, Florian, Hein, Ingo, Lopez, Eduardo C., Eduard Venter, Van Der Hoorn, Renier, Paul R. J. Birch, Pritchard, L., Borras-Hidalgo, Orlando, Hazel McLellan, Gilroy, Eleanor M., McLellan, H., Eleanor M. Gilroy, Hrubikova, Katarina, Birch, P., Orlando Borras-Hidalgo, Boevink, P., Eduardo C. López, Shaw, J., Maria Holeva, Jane Shaw, Loake, Gary J., Hrubikova, K., Katarina Hrubikova, Boevink, Petra C., Holeva, Maria, Venter, Eduard, Kaffarnik, F., McLellan, Hazel, Van der Hoorn, R., Venter, E., Lopez, E., Gary J. Loake, Hein, Ingo; id_orcid, Florian Kaffarnik, Renier Van Der Hoorn, Birch, Paul R. J.; id_orcid, Lacomme, Christophe, Loake, G., Borras-Hidalgo, O., Pritchard, Leighton, Lacomme, C., Ingo Hein, Birch, Paul R. J., Leighton Pritchard, Holeva, M., Gilroy, E., Petra C. Boevink   +49 more
core   +1 more source

Serine Protease Inhibition by a Silanediol Peptidomimetic

, 2016
Silanediol peptidomimetics are demonstrated to inhibit a serine protease. Asymmetric synthesis of the inhibitor was accomplished using Brown hydroboration and CBS reduction of an acylsilane intermediate.
Scott McN. Sieburth (1538176), Swapnil Singh (2047396)   +1 more
core   +1 more source

ClgR regulation of chaperone and protease systems is essential for Mycobacterium tuberculosis parasitism of the macrophage [PDF]

, 2010
Chaperone and protease systems play essential roles in cellular homeostasis and have vital functions in controlling the abundance of specific cellular proteins involved in processes such as transcription, replication, metabolism and virulence.
Smith, H.E., Butler, R.E., Thole, J.E.R., Harders-Westerveen, S.F., Kierzek, A., Neyrolles, O., Estorninho, M., Stewart, G.R.   +7 more
core   +1 more source