Results 161 to 170 of about 259,085 (245)

Hepatocyte growth factor activator inhibitor-2 rapidly inactivates airway-expressed human type II transmembrane serine proteases. [PDF]

J Biol Chem
Fraser BJ, Wilson RP, Lac J, Ilyassov O, Seitova A, Li Y, Hutchinson A, Li YY, Loppnau P, Kutera M, Morin GB, Bénard F, Arrowsmith CH.   +12 more
europepmc   +1 more source

Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase

Advanced Science, EarlyView.
GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko, Dongyoon Shin, Junho Park, June Huh, Youngsoo Kim, Jong‐Wan Park   +5 more
wiley   +1 more source

Lipid Metabolic Dysregulation Driven by OSMR Mutations Underlies Amyloidogenesis in Primary Localized Cutaneous Amyloidosis

Advanced Science, EarlyView.
OSMR mutations disrupt STAT5 signaling and AKR1B10‐mediated lipid metabolism, leading to lipid accumulation and protein aggregation in keratinocytes. This metabolic reprogramming drives amyloid deposition in primary localized cutaneous amyloidosis, revealing a mechanistic link between lipid dysregulation and amyloidogenesis.
Huiting Liu, Wen Zheng, Chao Yang, Tao Yang, Qiuyu Chen, Ping Lu, Huan Yang, Jun Liu, Bin Yang   +8 more
wiley   +1 more source

Impact of dipeptidyl peptidase I and neutrophil serine proteases on neutrophil functional responses. [PDF]

Front Pharmacol
Li D, Chen KJ, Niranjan N, Basso J, LaSala D, Pang MF, Smith C, Nguyen T, de Carvalho Oliveira V, Cipolla DC, McDonald PP.   +10 more
europepmc   +1 more source

Functions and evolution of FAM111 serine proteases. [PDF]

Front Mol Biosci, 2022
Welter AL, Machida YJ.
europepmc   +1 more source

A study of the expression and roles of Bacillus subtilis HtrA-type serine proteases

, 2003
THESIS 7278Upon sequencing a region of the Bacillus subtilis genome assigned to the author of this thesis, an open reading frame encoding a homologue of an HtrA-type serine protease, YkdA, was identified.
Noone, David
core  

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

Podocytes as novel sources of neutrophil serine proteases: expression and regulation by inflammatory molecular patterns. [PDF]

Cell Mol Life Sci
Wróblewska-Schmude A, Audzeyenka I, Mallek W, Wysocka M, Lesner A, Narajczyk M, Gajdowska F, Gutowska-Owsiak D, Kulesza T, Rogacka D, Piwkowska A.   +10 more
europepmc   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Secretion of serine proteases by planktonic- and biofilm-growing cells of Candida parapsilosis. [PDF]

Braz J Microbiol
Gandra RM, Giovanini L, Branquinha MH, Santos ALS.   +3 more
europepmc   +1 more source