Results 221 to 230 of about 226,366 (284)

Structural Catalytic Core in Subtilisin-like Proteins and Its Comparison to Trypsin-like Serine Proteases and Alpha/Beta-Hydrolases. [PDF]

Int J Mol Sci
Denesyuk AI, Denessiouk K, Johnson MS, Uversky VN.   +3 more
europepmc   +1 more source

A Comprehensive 19F NMR Framework for Fragment‐Based Drug Discovery: The Validated Screening Library OpenFL600 and Efficient Affinity Ranking by CSAR

Angewandte Chemie, EarlyView.
NMR screening is a powerful method for hit detection in drug‐discovery. We designed and validated the OpenFL600 19F$^{19}{\rm F}$ NMR library to probe diverse targets, including RNA, GPCRs, kinases, and proteases. This library yields target‐specific ligands without generating promiscuous binders.
Simon H. Rüdisser, Gabriela Stadler, Giacomo Padroni, Daria Barbash, Marco M. Ruckstuhl, Nils Lorz, Christina Jordan, Sarah Skibinski, Timo T. Stühlinger, Sarah E. Kratzwald, Katharina M. Siess, Sven Brüschweiler, Gerald Platzer, Antoine Cléry, Robert Konrat, Frédéric H.‐.T. Allain, Alvar D. Gossert   +16 more
wiley   +2 more sources

<i>Entamoeba histolytica</i>-induced NETs are highly cytotoxic on hepatic and colonic cells due to serine proteases and myeloperoxidase activities. [PDF]

Front Immunol
Jorge-Rosas F, Díaz-Godínez C, García-Aguirre S, Martínez-Calvillo S, Carrero JC.   +4 more
europepmc   +1 more source

Peptidthioester und Peptidtriazolderivate durch Duale Modifikation von Peptidthiosulfonaten auf dem Harz

Angewandte Chemie, EarlyView.
Es wird eine Strategie zur dualen Modifikation von Peptiden auf der Festphase vorgestellt, die die S‐Alkinylierung von Peptidthiosulfonaten und eine regioselektive, iridiumkatalysierte Azid‐Thioalkin‐Zykloaddition umfasst. Dieses Verfahren ermöglicht zuverlässig den Zugang zu Peptiden mit komplexen, nicht‐kanonischen Modifikationen und ist mit ...
Marius Werner, Agnes Bergmann, Chenxi Liu, Mira Behnam, Christian Klein, Franziska Thomas   +5 more
wiley   +1 more source

Homology-based identification and structural analysis of Pangasius hypophthalmus Annexins and Serine proteases to search molecules for wound healing applications. [PDF]

Comput Struct Biotechnol J
Avila Rodríguez MI, Velez Rueda AJ, Hernández-Pérez J, Benavides J, Sanchez ML.   +4 more
europepmc   +1 more source

Proteomics of Bacterial and Mouse Extracellular Vesicles Released in the Gastrointestinal Tracts of Nutrient-Stressed Animals Reveals an Interplay Between Microbial Serine Proteases and Mammalian Serine Protease Inhibitors. [PDF]

Int J Mol Sci
Stentz R, Jones E, Gul L, Latousakis D, Parker A, Brion A, Goldson AJ, Gotts K, Carding SR.   +8 more
europepmc   +1 more source

Structural and functional characterisation of isolated puff adder ( B. arietans ) serine proteases

Wilkinson MC, Modahl CM, Saviola A, Tianyi F, Harrison RA, Casewell NR.   +5 more
europepmc   +1 more source

Neutrophil serine proteases in cystic fibrosis: role in disease pathogenesis and rationale as a therapeutic target. [PDF]

Eur Respir Rev
Mall MA, Davies JC, Donaldson SH, Jain R, Chalmers JD, Shteinberg M.   +5 more
europepmc   +1 more source

Bacillaceae serine proteases and Streptomyces epsilon-poly-L-lysine synergistically inactivate Caliciviridae by inhibiting RNA genome release. [PDF]

Sci Rep
Yamamoto S, Ogasawara N, Sudo-Yokoyama Y, Sato S, Takata N, Yokota N, Nakano T, Hayashi K, Takasawa A, Endo M, Hinatsu M, Yoshida K, Sato T, Takahashi S, Takano K, Kojima T, Hiraki J, Yokota SI.   +17 more
europepmc   +1 more source

The Proteolytic Activity of Neutrophil-Derived Serine Proteases Bound to the Cell Surface Arming Lung Epithelial Cells for Viral Defense. [PDF]

Molecules
Assylbekova A, Allayarova M, Konysbekova M, Bekturgan A, Makhanova A, Brown S, Grzegorzek N, Kalbacher H, Kalendar R, Burster T.   +9 more
europepmc   +1 more source