Results 31 to 40 of about 95,153 (249)
SPINK6 inhibits human airway serine proteases and restricts influenza virus activation
EMBO Molecular Medicine, 2021 SPINK6 was identified in human skin as a cellular inhibitor of serine proteases of the KLK family. Airway serine proteases are required to cleave hemagglutinin (HA) of influenza A viruses (IAVs) to initiate an infection in the human airway.
Dong Wang +15 more
doaj +1 more source
BMC Genomics, 2008 Background Serine proteases are one of the most abundant groups of proteolytic enzymes found in all the kingdoms of life. While studies have established significant roles for many prokaryotic serine proteases in several physiological processes, such as ...
Tripathi Lokesh P, Sowdhamini R
doaj +1 more source
Airway proteolytic control of pneumococcal competence.
PLoS Pathogens, 2023 Streptococcus pneumoniae is an opportunistic pathogen that colonizes the upper respiratory tract asymptomatically and, upon invasion, can lead to severe diseases including otitis media, sinusitis, meningitis, bacteremia, and pneumonia.
Haley Echlin +3 more
doaj +1 more source
Serine Proteases in Rodent Hippocampus [PDF]
Journal of Biological Chemistry, 1998 Brain serine proteases are implicated in developmental processes, synaptic plasticity, and in disorders including Alzheimer's disease. The spectrum of the major enzymes expressed in brain has not been established previously. We now present a systematic study of the serine proteases expressed in adult rat and mouse hippocampus.
Davies, Ben J. +4 more
openaire +4 more sources
New insights into the evolution of subtilisin-like serine protease genes in Pezizomycotina
BMC Evolutionary Biology, 2010 Background Subtilisin-like serine proteases play an important role in pathogenic fungi during the penetration and colonization of their hosts. In this study, we perform an evolutionary analysis of the subtilisin-like serine protease genes of subphylum ...
Zhang Ying +9 more
doaj +1 more source
eLife, 2021 Coronavirus entry is mediated by the spike protein that binds the receptor and mediates fusion after cleavage by host proteases. The proteases that mediate entry differ between cell lines, and it is currently unclear which proteases are relevant in vivo.
Anna Z Mykytyn +7 more
doaj +1 more source
Serine Proteases of Malaria Parasite Plasmodium falciparum: Potential as Antimalarial Drug Targets
Interdisciplinary Perspectives on Infectious Diseases, 2014 Malaria is a major global parasitic disease and a cause of enormous mortality and morbidity. Widespread drug resistance against currently available antimalarials warrants the identification of novel drug targets and development of new drugs.
Asrar Alam
doaj +1 more source
Cross genome comparisons of serine proteases in Arabidopsis and rice
BMC Genomics, 2006 Background Serine proteases are one of the largest groups of proteolytic enzymes found across all kingdoms of life and are associated with several essential physiological pathways.
Sowdhamini R, Tripathi Lokesh P
doaj +1 more source
Streptococcus pneumoniae serine protease HtrA, but not SFP or PrtA, is a major virulence factor in pneumonia. [PDF]
PLoS ONE, 2013 Streptococcus (S.) pneumoniae is a common causative pathogen in pneumonia. Serine protease orthologs expressed by a variety of bacteria have been found of importance for virulence. Previous studies have identified two serine proteases in S.
Sacha F de Stoppelaar +6 more
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Frontiers in Immunology, 2022 Phenoloxidase (PO)–catalyzed melanization is a vital immune response in insects for defense against pathogen infection. This process is mediated by clip domain serine proteases and regulated by members of the serpin superfamily. We here revealed that the
Jiayue Ji +6 more
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