Results 41 to 50 of about 259,085 (245)

The human Transmembrane Protease Serine 2 is necessary for the production of Group 2 influenza A virus pseudotypes [PDF]

, 2013
The monomer of influenza haemagglutinin is synthesized as a single polypeptide precursor that during maturation is cleaved by proteases into two active subunits. Other studies have demonstrated that the human Transmembrane Protease Serine 2 (TMPRSS2) can
Ferrara, Francesca, Böttcher-Friebertshäuser, Eva, Temperton, Nigel J., Scott, Simon D., Corti, Davide, Cattoli, Giovanni, Molesti, Eleonora, Böttcher-Frieberthäuser, Eva   +7 more
core   +1 more source

SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site

eLife, 2021
Coronavirus entry is mediated by the spike protein that binds the receptor and mediates fusion after cleavage by host proteases. The proteases that mediate entry differ between cell lines, and it is currently unclear which proteases are relevant in vivo.
Anna Z Mykytyn, Tim I Breugem, Samra Riesebosch, Debby Schipper, Petra B van den Doel, Robbert J Rottier, Mart M Lamers, Bart L Haagmans   +7 more
doaj   +1 more source

T-SP1: a novel serine protease-like protein predominantly expressed in testis [PDF]

, 2008
Here, we describe a novel member in the group of membrane-anchored chymotrypsin (S1)-like serine proteases, namely testis serine protease 1 (T-SP1), as it is principally expressed in testis tissue.
Nerlich, Andreas, Profanter, Birgit, Geissler, Claudia, Neth, Peter, Sommerhoff, Christian P., Naegler, Dorit K., Jochum, Marianne   +6 more
core   +1 more source

Identification of proteases employed by dendritic cells in the processing of protein purified derivative (PPD) [PDF]

, 2004
Dendritic cells (DC) are known to present exogenous protein Ag effectively to T cells. In this study we sought to identify the proteases that DC employ during antigen processing.
Mansour Mohamadzadeh, Brammer, Melissa, Luftig, Ronald B., Sestak, Karol, Melissa Brammer, Karol Sestak, Ronald B Luftig, Mohamadzadeh, Hamid, Hamid Mohamadzadeh, Mohamadzadeh, Mansour   +9 more
core   +1 more source

Serine Proteases of Malaria Parasite Plasmodium falciparum: Potential as Antimalarial Drug Targets

Interdisciplinary Perspectives on Infectious Diseases, 2014
Malaria is a major global parasitic disease and a cause of enormous mortality and morbidity. Widespread drug resistance against currently available antimalarials warrants the identification of novel drug targets and development of new drugs.
Asrar Alam
doaj   +1 more source

Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesis [PDF]

, 2003
Many serine proteases play important regulatory roles in complex biological systems, but only a few have been linked directly with capillary morphogenesis and angiogenesis.
Fuchs, Simone, Steven Ogbourne, Hooper, JD, Sit, M-L, Fuchs, S, Antalis, T M, Aimes, RT, Ogbourne, SM, Quigley, James P., Ogbourne, S, Simone Fuchs, Hooper, John D., Hooper, J D, Sit, ML, Aimes, Ronald T., Ogbourne, Steven M., Ronald Aimes, Zijlstra, A, Zijlstra, Andries, Antalis, TM, Quigley, J P, James Quigley, Toni Antalis, Gotley, David C., Sit, Mae-le, Gotley, DC, Gotley, D C, Mae-Le Sit, Antalis, Toni M., Andries Zijlstra, Quigley, JP, Aimes, R T, David Gotley, John Hooper   +33 more
core   +1 more source

Cross genome comparisons of serine proteases in Arabidopsis and rice

BMC Genomics, 2006
Background Serine proteases are one of the largest groups of proteolytic enzymes found across all kingdoms of life and are associated with several essential physiological pathways.
Sowdhamini R, Tripathi Lokesh P
doaj   +1 more source

Streptococcus pneumoniae serine protease HtrA, but not SFP or PrtA, is a major virulence factor in pneumonia. [PDF]

PLoS ONE, 2013
Streptococcus (S.) pneumoniae is a common causative pathogen in pneumonia. Serine protease orthologs expressed by a variety of bacteria have been found of importance for virulence. Previous studies have identified two serine proteases in S.
Sacha F de Stoppelaar, Hester J Bootsma, Aldert Zomer, Joris J T H Roelofs, Peter W M Hermans, Cornelis van 't Veer, Tom van der Poll   +6 more
doaj   +1 more source

Serpin–4 Facilitates Baculovirus Infection by Inhibiting Melanization in Asian Corn Borer, Ostrinia furnacalis (Guenée)

Frontiers in Immunology, 2022
Phenoloxidase (PO)–catalyzed melanization is a vital immune response in insects for defense against pathogen infection. This process is mediated by clip domain serine proteases and regulated by members of the serpin superfamily. We here revealed that the
Jiayue Ji, Dongxu Shen, Dongxu Shen, Dongxu Shen, Shasha Zhang, Lei Wang, Chunju An   +6 more
doaj   +1 more source

Serpin functions in host-pathogen interactions [PDF]

PeerJ, 2018
Serpins are a broadly distributed superfamily of protease inhibitors that are present in all kingdoms of life. The acronym, serpin, is derived from their function as potent serine proteases inhibitors.
Jialing Bao, Guoqing Pan, Mortimer Poncz, Junhong Wei, Maoshuang Ran, Zeyang Zhou   +5 more
doaj   +2 more sources