Results 41 to 50 of about 287,026 (286)

Streptococcus pneumoniae serine protease HtrA, but not SFP or PrtA, is a major virulence factor in pneumonia. [PDF]

PLoS ONE, 2013
Streptococcus (S.) pneumoniae is a common causative pathogen in pneumonia. Serine protease orthologs expressed by a variety of bacteria have been found of importance for virulence. Previous studies have identified two serine proteases in S.
Sacha F de Stoppelaar, Hester J Bootsma, Aldert Zomer, Joris J T H Roelofs, Peter W M Hermans, Cornelis van 't Veer, Tom van der Poll   +6 more
doaj   +1 more source

Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesis [PDF]

, 2003
Many serine proteases play important regulatory roles in complex biological systems, but only a few have been linked directly with capillary morphogenesis and angiogenesis.
Fuchs, Simone, Steven Ogbourne, Hooper, JD, Sit, M-L, Fuchs, S, Antalis, T M, Aimes, RT, Ogbourne, SM, Quigley, James P., Ogbourne, S, Simone Fuchs, Hooper, John D., Hooper, J D, Sit, ML, Aimes, Ronald T., Ogbourne, Steven M., Ronald Aimes, Zijlstra, A, Zijlstra, Andries, Antalis, TM, Quigley, J P, James Quigley, Toni Antalis, Gotley, David C., Sit, Mae-le, Gotley, DC, Gotley, D C, Mae-Le Sit, Antalis, Toni M., Andries Zijlstra, Quigley, JP, Aimes, R T, David Gotley, John Hooper   +33 more
core   +1 more source

Serpin functions in host-pathogen interactions [PDF]

PeerJ, 2018
Serpins are a broadly distributed superfamily of protease inhibitors that are present in all kingdoms of life. The acronym, serpin, is derived from their function as potent serine proteases inhibitors.
Jialing Bao, Guoqing Pan, Mortimer Poncz, Junhong Wei, Maoshuang Ran, Zeyang Zhou   +5 more
doaj   +2 more sources

Serpin–4 Facilitates Baculovirus Infection by Inhibiting Melanization in Asian Corn Borer, Ostrinia furnacalis (Guenée)

Frontiers in Immunology, 2022
Phenoloxidase (PO)–catalyzed melanization is a vital immune response in insects for defense against pathogen infection. This process is mediated by clip domain serine proteases and regulated by members of the serpin superfamily. We here revealed that the
Jiayue Ji, Dongxu Shen, Dongxu Shen, Dongxu Shen, Shasha Zhang, Lei Wang, Chunju An   +6 more
doaj   +1 more source

Purification of serine proteases from mango (Mangifera indica cv. Chokanan) peel using expanded bed adsorption: optimisation using response surface methodology [PDF]

, 2014
Proteolytic enzymes or proteases are a class of proteins ubiquitously found in all organisms; they act as catalysts and perform diverse vital functions. In plants, proteases of plant origin play a vital function from the mobilisation of storage proteins ...
Abd Manap, Mohd Yazid, Amid, Mehrnoush
core   +1 more source

An endocannabinoid tone limits excitotoxicity in vitro and in a model of multiple sclerosis

Neurobiology of Disease, 2010
The aim of this study was to evaluate how endocannabinoids interact with excitotoxic processes both in vitro, using primary neural cell cultures, and in vivo, in the TMEV-IDD model of multiple sclerosis.
F. Loría, S. Petrosino, M. Hernangómez, L. Mestre, A. Spagnolo, F. Correa, V. Di Marzo, F. Docagne, C. Guaza   +8 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Pretreatment with serine protease inhibitors impairs Leishmania amazonensis survival on macrophages

Parasites & Vectors
Background Leishmaniases are neglected tropical diseases with great clinical and epidemiological importance. The current chemotherapy available for the treatment of leishmaniasis presents several problems, such as adverse effects, toxicity, long ...
Patrícia de Almeida Machado, Pollyanna Stephanie Gomes, Elaine Soares Coimbra, Herbert Leonel de Matos Guedes   +3 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2–Priming Protease TMPRSS2

Pathogens and Immunity, 2021
Background: Host proteases have been suggested to be crucial for dissemination of MERS, SARS-CoV, and SARS-CoV-2 coronaviruses, but the relative contribution of membrane versus intracellular proteases remains controversial. Transmembrane serine protease
Nurit P Azouz, Andrea Klingler, Victoria Callahan, Ivan Akhrymuk, Katarina Elez, Lluís Raich, Brandon Henry, Justin Benoit, Stefanie Benoit, Frank Noé, Kylene Kehn-Hall, Marc Rothenberg   +11 more
doaj   +1 more source