IUBMB Life, 2009 AbstractOver one third of all known proteolytic enzymes are serine proteases. Among these, the trypsins underwent the most predominant genetic expansion yielding the enzymes responsible for digestion, blood coagulation, fibrinolysis, development, fertilization, apoptosis, and immunity.
Enrico Di Cera
exaly +4 more sources
Serine Proteases in Rodent Hippocampus [PDF]
Journal of Biological Chemistry, 1998 Brain serine proteases are implicated in developmental processes, synaptic plasticity, and in disorders including Alzheimer's disease. The spectrum of the major enzymes expressed in brain has not been established previously. We now present a systematic study of the serine proteases expressed in adult rat and mouse hippocampus.
Davies, Ben J. +4 more
core +8 more sources
Staphylococcal SplA and SplB serine proteases target ubiquitin(-like) specific proteases [PDF]
AMB ExpressStaphylococcus aureus is a Gram-positive opportunistic pathogen that has colonized nearly 30% of the human population and can cause life-threatening infections. S. aureus exports a variety of virulence factors, such as a novel set of extracellular serine
Felix L. Glinka +13 more
doaj +2 more sources
Serine proteases and metalloproteases are highly increased in irritable bowel syndrome Tunisian patients [PDF]
Scientific Reports, 2023 Serine proteases are involved in many biological processes and are associated with irritable bowel syndrome (IBS) pathology. An increase in serine protease activity has been widely reported in IBS patients.
Souha Soussou +10 more
doaj +2 more sources
The Versatility of Serine Proteases from Brazilian Bothrops Venom: Their Roles in Snakebites and Drug Discovery [PDF]
BiomoleculesSerine proteases are multifunctional and versatile venom components found in viper snakes, including the Bothrops species, a widely distributed genus notorious for causing the highest number of snakebites across Latin America. These enzymes, representing
Marcela Romanazzi +12 more
doaj +2 more sources
Exploring the Diversity and Function of Serine Proteases in Toxicofera Reptile Venoms: A Comprehensive Overview [PDF]
ToxinsToxicofera reptile venoms are composed of several toxins, including serine proteases. These proteases are glycosylated enzymes that affect the prey’s hemostatic system. Their actions extend across the coagulation cascade, the kallikrein–kinin system, and
Julia F. D. Vidal +7 more
doaj +2 more sources
Airborne indoor allergen serine proteases and their contribution to sensitisation and activation of innate immunity in allergic airway disease [PDF]
European Respiratory ReviewCommon airborne allergens (pollen, animal dander and those from fungi and insects) are the main triggers of type I allergic disorder in the respiratory system and are associated with allergic rhinitis, allergic asthma, as well as immunoglobulin E (IgE ...
Xuan Ouyang +3 more
doaj +2 more sources
Design, synthesis, and evaluation of Bothrops venom serine protease peptidic inhibitors [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2021 Background: In Central and South America, snakebite envenomation is mainly caused by Bothrops spp. snakes, whose venoms feature significant biochemical richness, including serine proteases.
Gloria Maria da Silva +8 more
doaj +1 more source
REVIEW OF SERINE PROTEASE INHIBITORS: DEVELOPMENT AND APPLICATIONS [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2023 A class of enzymes known as proteases is responsible for catalyzing the breakdown of covalent peptide bonds. Proteases account for almost 2% of the genes in humans, infectious organisms, and other forms of life.
Mai Ramadan
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2021 The pathobiont Streptococcus pneumoniae causes life-threatening diseases, including pneumonia, sepsis, meningitis, or non-invasive infections such as otitis media.
Murtadha Q. Ali +4 more
doaj +1 more source