Results 51 to 60 of about 249,259 (283)

Serpin–4 Facilitates Baculovirus Infection by Inhibiting Melanization in Asian Corn Borer, Ostrinia furnacalis (Guenée)

Frontiers in Immunology, 2022
Phenoloxidase (PO)–catalyzed melanization is a vital immune response in insects for defense against pathogen infection. This process is mediated by clip domain serine proteases and regulated by members of the serpin superfamily. We here revealed that the
Jiayue Ji, Dongxu Shen, Dongxu Shen, Dongxu Shen, Shasha Zhang, Lei Wang, Chunju An   +6 more
doaj   +1 more source

Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesis [PDF]

, 2003
Many serine proteases play important regulatory roles in complex biological systems, but only a few have been linked directly with capillary morphogenesis and angiogenesis.
Fuchs, Simone, Steven Ogbourne, Hooper, JD, Sit, M-L, Fuchs, S, Antalis, T M, Aimes, RT, Ogbourne, SM, Quigley, James P., Ogbourne, S, Simone Fuchs, Hooper, John D., Hooper, J D, Sit, ML, Aimes, Ronald T., Ogbourne, Steven M., Ronald Aimes, Zijlstra, A, Zijlstra, Andries, Antalis, TM, Quigley, J P, James Quigley, Toni Antalis, Gotley, David C., Sit, Mae-le, Gotley, DC, Gotley, D C, Mae-Le Sit, Antalis, Toni M., Andries Zijlstra, Quigley, JP, Aimes, R T, David Gotley, John Hooper   +33 more
core   +1 more source

Family C1 cysteine proteases: Biological diversity or redundancy? [PDF]

, 2003
Recent progress in the identification and partial characterization of novel genes encoding cysteine proteases of the papain family has considerably increased our knowledge of this family of enzymes.
Nägler, D. K., Ménard, R., Ménard, Robert, Nägler, Dorit K.   +3 more
core   +1 more source

Ecotin-like serine peptidase inhibitor ISP1 of Leishmania major plays a role in flagellar pocket dynamics and promastigote differentiation [PDF]

, 2012
Leishmania ISPs are ecotin-like natural peptide inhibitors of trypsin-family serine peptidases, enzymes that are absent from the Leishmania genome. This led to the proposal that ISPs inhibit host serine peptidases and we have recently shown that ISP2 ...
Petr Volf, Mottram, Jeremy C, Gareth D. Westrop, Eschenlauer, Sylvain C, Volf, Petr, Amy Goundry, Sylvain C. Eschenlauer, Jeremy C. Mottram, Lima, Ana Paula C A, Lima, Ana Paula C.A., Morrison, Lesley S, Morrison, Lesley S., Lesley S. Morrison, Ana Paula C. A. Lima, Goundry, Amy, Faria, Marilia S, Marilia S. Faria, Graham H. Coombs, Westrop, Gareth D., Coombs, Graham H, Anna Dostalova, Laurence Tetley, Faria, Marilia S., Tetley, Laurence, Dostalova, Anna, Westrop, Gareth D, Mottram, Jeremy C., Eschenlauer, Sylvain C., Coombs, Graham H.   +28 more
core   +1 more source

An endocannabinoid tone limits excitotoxicity in vitro and in a model of multiple sclerosis

Neurobiology of Disease, 2010
The aim of this study was to evaluate how endocannabinoids interact with excitotoxic processes both in vitro, using primary neural cell cultures, and in vivo, in the TMEV-IDD model of multiple sclerosis.
F. Loría, S. Petrosino, M. Hernangómez, L. Mestre, A. Spagnolo, F. Correa, V. Di Marzo, F. Docagne, C. Guaza   +8 more
doaj   +1 more source

Characteristics of intracellular peptidase and proteinase activities from the mycelium of a cord-forming wood decay fungus Serpula lacrymans [PDF]

, 2001
Serpula lacrymans is a basidiomycete cord-forming wood decay fungus which reallocates nitrogen within an extensive perennial mycelial system in response to spatial discontinuities in external nutrient supply.
Burton, Kerry S., Watkinson, Sarah C., Wood, David A.   +2 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Purification of serine proteases from mango (Mangifera indica cv. Chokanan) peel using expanded bed adsorption: optimisation using response surface methodology [PDF]

, 2014
Proteolytic enzymes or proteases are a class of proteins ubiquitously found in all organisms; they act as catalysts and perform diverse vital functions. In plants, proteases of plant origin play a vital function from the mobilisation of storage proteins ...
Abd Manap, Mohd Yazid, Amid, Mehrnoush
core   +1 more source

Pretreatment with serine protease inhibitors impairs Leishmania amazonensis survival on macrophages

Parasites & Vectors
Background Leishmaniases are neglected tropical diseases with great clinical and epidemiological importance. The current chemotherapy available for the treatment of leishmaniasis presents several problems, such as adverse effects, toxicity, long ...
Patrícia de Almeida Machado, Pollyanna Stephanie Gomes, Elaine Soares Coimbra, Herbert Leonel de Matos Guedes   +3 more
doaj   +1 more source

Potential Therapeutic Targeting of Coronavirus Spike Glycoprotein Priming

Molecules, 2020
Processing of certain viral proteins and bacterial toxins by host serine proteases is a frequent and critical step in virulence. The coronavirus spike glycoprotein contains three (S1, S2, and S2′) cleavage sites that are processed by human host proteases.
Elisa Barile, Carlo Baggio, Luca Gambini, Sergey A. Shiryaev, Alex Y. Strongin, Maurizio Pellecchia   +5 more
doaj   +1 more source