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Targeting Serine Proteases in Asthma
Current Topics in Medicinal Chemistry, 2006Leukocytes and lung structural cells contribute to the pathophysiology of asthma through the production of numerous mediators including serine proteases. Such proteases include mast cell tryptase and chymase; neutrophil elastase, cathepsin G and myeloblastin (proteinase 3); bronchial epithelial cell-derived transmembrane protease, serine 11D (human ...
Caroline, Guay +2 more
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Strategies for the inhibition of serine proteases
Cellular and Molecular Life Sciences, 2001Serine proteases have been shown to play a multifarious role in health and disease. As a result, there has been considerable interest in the design and development of synthetic inhibitors of these enzymes. In view of their diverse roles in biological processing events, one of the great challenges in such endeavours has been the need to produce ...
B, Walker, J F, Lynas
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Serine proteases and cardiac function
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2005The serine proteases of the trypsin superfamily are versatile enzymes involved in a variety of biological processes. In the cardiovascular system, the importance of these enzymes in blood coagulation, platelet activation, fibrinolysis, and thrombosis has been well established.
Qingyu, Wu +2 more
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Cell surface–anchored serine proteases in cancer progression and metastasis
Cancer and Metastasis Reviews, 2019Karin List
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Unconventional serine proteases: Variations on the catalytic Ser/His/Asp triad configuration
Protein Science, 2008Mark Paetzel, Ross E. Dalbey
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Gene silencing of serine proteases affects melanization of Sephadex beads in
Insect Biochemistry and Molecular Biology, 2006Susan M Paskewitz
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