An atypical and functionally diverse family of Kunitz-type cysteine/serine proteinase inhibitors secreted by the helminth parasite Fasciola hepatica. [PDF]
Sci Rep, 2020 Smith D +4 more
europepmc +1 more source
Advanced Science, EarlyView.Inflammatory bowel disease (IBD) pathogenesis remains unclear. This study reveals that thymus‐originated IL‐7R‐enriched extracellular vesicles exacerbate colitis by promoting neutrophil extracellular traps via a thymus‐gut axis, uncovering an inter‐organ communication mechanism in inflammatory bowel disease pathogenesis.
Yao Liao +21 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan +12 more
wiley +1 more source
Regulation and regulatory role of proteinase inhibitors [PDF]
, 1995 Excess or ill-timed proteolytic events have, of necessity, to be restrained. Therefore, there are partner proteinase inhibitors to most of the known mammalian enzymes that cleave peptide bonds, a situation that implicates the inhibitors in a myriad of ...
Roberts, R. Michael +3 more
core
Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis
Advanced Science, EarlyView.In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley +1 more source
Proteinase-proteinase inhibitor imbalance in inflammation and multiple trauma with special amphasis on release of granulocytic lysosomal elastase [PDF]
, 1984 Elödi, P. +4 more
core +1 more source
Purification and characterization of serine proteinase inhibitors from two South African indigenous plants, Acacia karoo and Acacia schweinfurthii [PDF]
, 2009 Serine proteases are known to perform a wide range of functions essential to life; however there has to be some form of control mechanism in place.
Odei-Addo, Frank
core +1 more source
Memorias do Instituto Oswaldo Cruz, 1999 Streptomyces alboniger ATCC 12461 grown in brain heart infusion (BHI) medium produced two extracellular serine-proteinases, denoted SP I and SP II, which were purified by ammonium sulfate precipitation and aprotinin-agarose affinity chromatography.
Lopes Andréa +4 more
doaj
Inhibitors of Serine Proteinase - Application in Agriculture and Medicine
, 2012 Inhibitors are important elements of regulation of enzyme activity. They can be named ubiquitous components in living organisms (Fan & Wu, 2005). There is a number of inhibitors, such as protein and nonprotein. Among all inhibitors, the most significant are inhibitors of hydrolytic enzymes.
Rinat Islamov +2 more
openaire +2 more sources
Natural Variation of NAR5 Determines Nitrogenase Activity and the Yield in Soybean
Advanced Science, EarlyView.This study identified NAR5, a gene encoding a subtilisin‐like protease, that regulates nitrogenase activity in soybean nodules. Overexpressing NAR5 delayed nodule senescence, enhancing nitrogenase activity, yield, and low‐nitrogen tolerance. The elite haplotype NAR5HapI‐1 linked to superior nitrogenase activity and greater seed weight has been ...
Chao Ma +11 more
wiley +1 more source