Results 221 to 230 of about 72,685 (290)

A Novel Role of Neutrophil Elastase in Podocyte Dysfunction Induced by High Glucose, PMA, and MDP. [PDF]

J Cell Physiol
Kulesza T, Wróblewska A, Sawicka J, Audzeyenka I, Rachubik P, Rogacka D, Mallek W, Wysocka M, Lesner A, Piwkowska A.   +9 more
europepmc   +1 more source

COPD: the role of neutrophils in inflammation, pathophysiology, and as drug targets. [PDF]

Clin Sci (Lond)
Fricker M, Lokwani R.
europepmc   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Defense Mechanisms of Chickpea against Chickpea Pod Borer, <i>Helicoverpa armigera</i> and Chickpea Leafminer, <i>Liriomyza cicerina</i>: from Plant Morphology to Molecular Level. [PDF]

ACS Omega
Sane Y, El Fakhouri K, Boulamtat R, Sobeh M, El Bouhssini M.   +4 more
europepmc   +1 more source

Construction of a clickable probe‐based protein chip platform for discovering covalent mIDH1 inhibitors from natural medicinal extracts

iMeta, EarlyView.
In this study, we develop a flexible Ccc‐Chip (protein microarray + bioorthogonal click chemistry) for high‐throughput screening of natural covalent active molecules from medicinal plant extracts, identifying flavokawain C from Piper methysticum Forst as a novel covalent mIDH1 inhibitor.
Zhao Cui, Jiameng Li, Caifeng Li, Mo Sun, Wei Liu, Xuxia Cao, Shiwen Deng, Junxian Cao, Hongjun Yang, Peng Chen   +9 more
wiley   +1 more source

Host proteases: key regulators in viral infection and therapeutic targeting. [PDF]

Front Immunol
Xia Q, Liu X, Huang H.
europepmc   +1 more source

Structure, Biochemistry and Comparative Aspects of Mammalian Seminal Plasma Acrosin Inhibitors [PDF]

, 1976
Fink, Edwin, Fritz, Hans, Klauser, R., Kupfer, S., Peeters, H., Tschesche, Harald   +5 more
core  

Gut microbiome‐derived metabolites show promise in cancer research and therapy

Interdisciplinary Medicine, EarlyView.
The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang, Yifan Wang, Daolin Tang, Peilong Li, Lutao Du   +4 more
wiley   +1 more source

Trichinella spiralis serine protease mediates larval invasion of gut epithelium via binding to CK8 and activating RhoA/ROCK1 pathway. [PDF]

PLoS Negl Trop Dis
Zheng WW, Zhang XZ, Cong PK, Zhang R, Long SR, Zhang X, Liu RD, Wang ZQ, Cui J.   +8 more
europepmc   +1 more source

Biomarkers for the estimation of isoproterenol‐induced myocardial infarction: A review of key parameters

Journal of Intelligent Medicine, EarlyView.
Abstract The isoproterenol‐induced myocardial infarction model is a well‐established experimental approach for studying cardiac injury and testing potential protective treatments. By overstimulating beta‐adrenergic receptors, this model closely reproduces key features of human heart attacks, including oxidative damage, calcium imbalance, inflammatory ...
Bushra Imran, Tarique Mahmood, Farogh Ahsan, Shahzadi Bano, Vaseem Ahamad Ansari, Mohd Adnan   +5 more
wiley   +1 more source