Tumor Cell Migration May Be an Inherent “Foraging” Behavior
Tumor cells gradually form pseudopodia, migrate to necrotic cells, make contact with them, and absorb necrotic cell debris. During this migration, small vesicles formed by dying tumor cells also gradually migrate toward living tumor cells. Once the nutrients from the necrotic cells have been completely absorbed, the living tumor cells will leave ...
Fuqian Zhao +4 more
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Virtual screening and molecular dynamics studies of antivenom using flavonoid compounds derived from Andrographis echioides. [PDF]
Jeevitha P, Subash P, Khute S.
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Drug Discovery Strategies for Kallikrein-Related Peptidases. [PDF]
Dreyer T +3 more
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The Efficacy and Safety of Four Novel PCSK9 Monoclonal Antibodies in Patients With Hypercholesterolemia: A Systematic Review With Network Meta-Analysis and Trial Sequential Analysis. [PDF]
Wang S, Li C, Fan D.
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Research progress on the effect of neutrophil elastase and its inhibitors in respiratory diseases. [PDF]
Liang CC +4 more
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Protease profiling in fecal samples: a novel non-invasive diagnostic tool for gastrointestinal disorders. [PDF]
Baldassar L +8 more
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Thermostable Proteases from <i>Geobacillus</i>: Production, Characterization, Structural Stability Mechanisms and Biotechnological Applications. [PDF]
Wang M, Wang JW, Cheng JH.
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Plant Serine Proteinase Inhibitors
Protein & Peptide Letters, 2005Evidence that establishes the mechanism of the classes of plant proteinase inhibitors (PIs) is evaluated. Of the eight classes of PIs, six are unique to plants. Except for plant serpins, there is evidence that PIs from all other classes form tight binding complexes with their target proteinases, and that they follow the standard mechanism of inhibition.
John, Christeller, William, Laing
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Prediction of new serine proteinase inhibitors
Nature Structural & Molecular Biology, 1994We describe here the use of a rapid computational method to predict the relative binding strengths of a series of small-molecule ligands for the serine proteinase trypsin. Flexible molecular models of the ligands were docked to the proteinase using an all-atom potential set, without cutoff limits for the non-bonded and electrostatic energies.
I V, Kurinov, R W, Harrison
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