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Tumor Cell Migration May Be an Inherent “Foraging” Behavior

open access: yesMedicine Advances, EarlyView.
Tumor cells gradually form pseudopodia, migrate to necrotic cells, make contact with them, and absorb necrotic cell debris. During this migration, small vesicles formed by dying tumor cells also gradually migrate toward living tumor cells. Once the nutrients from the necrotic cells have been completely absorbed, the living tumor cells will leave ...
Fuqian Zhao   +4 more
wiley   +1 more source

Drug Discovery Strategies for Kallikrein-Related Peptidases. [PDF]

open access: yesInt J Mol Sci
Dreyer T   +3 more
europepmc   +1 more source

Protease profiling in fecal samples: a novel non-invasive diagnostic tool for gastrointestinal disorders. [PDF]

open access: yesSci Rep
Baldassar L   +8 more
europepmc   +1 more source
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Plant Serine Proteinase Inhibitors

Protein & Peptide Letters, 2005
Evidence that establishes the mechanism of the classes of plant proteinase inhibitors (PIs) is evaluated. Of the eight classes of PIs, six are unique to plants. Except for plant serpins, there is evidence that PIs from all other classes form tight binding complexes with their target proteinases, and that they follow the standard mechanism of inhibition.
John, Christeller, William, Laing
openaire   +2 more sources

Prediction of new serine proteinase inhibitors

Nature Structural & Molecular Biology, 1994
We describe here the use of a rapid computational method to predict the relative binding strengths of a series of small-molecule ligands for the serine proteinase trypsin. Flexible molecular models of the ligands were docked to the proteinase using an all-atom potential set, without cutoff limits for the non-bonded and electrostatic energies.
I V, Kurinov, R W, Harrison
openaire   +2 more sources

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