Results 291 to 300 of about 128,354 (367)
Abstract The objective of the current study was to evaluate the rate and extent of absorption of a test formulation (sitagliptin hydrochloride) and a reference formulation (sitagliptin phosphate). An open‐label, randomized, single‐dose, single‐center, 2‐sequence, 2‐period, and cross‐over phase 1 study was implemented to assess the pharmacokinetic ...
Usok Hyun+7 more
wiley +1 more source
Anti-Melanoma Activity and Potential Mechanism of Purified Potato Protease Inhibitor. [PDF]
Li Q+6 more
europepmc +1 more source
Azathioprine is used to treat several inflammatory and autoimmune diseases. However, its use is limited by serious adverse events, including acute pancreatitis. Prior studies have found an association between the HLA region and thiopurine‐induced acute pancreatitis (TIAP); however, in clinical practice, many patients with pancreatitis do not meet this ...
Shailja C. Shah+16 more
wiley +1 more source
Redefining the Skin Barrier: A Microbiome‐Integrated Multilayered Defense Model
ABSTRACT The skin constitutes a dynamic interface orchestrating a sophisticated multilayered defense system comprising physical, chemical, immune, and microbial barriers. This review synthesizes current understanding of the structural and functional integration of these barriers, emphasizing their synergistic interactions in maintaining cutaneous ...
Jingjing Xia+4 more
wiley +1 more source
Integrating Surface Plasmon Resonance and Docking Analysis for Mechanistic Insights of Tryptase Inhibitors. [PDF]
Porta A+8 more
europepmc +1 more source
Abstract Background The emergence of multicellularity in animals marks a pivotal evolutionary event, which was likely enabled by molecular innovations in the way cells adhere and communicate with one another. β‐Catenin is significant to this transition due to its dual role as both a structural component in the cadherin–catenin complex and as a ...
Brian M. Walters+5 more
wiley +1 more source
Lysosomal Proteases and Their Inhibitors. [PDF]
Turk V, Stoka V.
europepmc +1 more source
Bioinformatics analysis of immune‐programmed cell death‐related genes in nasopharyngeal carcinoma
Abstract Background Nasopharyngeal carcinoma (NPC) is a prevalent malignant tumor of the head and neck, characterized by a complex pathogenesis. Most newly diagnosed NPC patients are locally advanced, and 20%–30% of advanced NPC patients have poor immunotherapy results.
Hongqiang Chen+3 more
wiley +1 more source
α‑1 Antitrypsin is a potential target of inflammation and immunomodulation (Review). [PDF]
Wang T+7 more
europepmc +1 more source