Investigating the mechanisms of capsicum in age‐related hearing loss: Based on network pharmacology
Abstract Background To explore the material basis and action mechanism of the chemical component gene of pepper on presbycusis, and to provide a reference for the traditional Chinese medicine treatment of age‐related hearing loss (ARHL). Methods The chemical composition and action targets of traditional Chinese medicine flavor of pepper were searched ...
Yan Wang+9 more
wiley +1 more source
Proteomics of Bacterial and Mouse Extracellular Vesicles Released in the Gastrointestinal Tracts of Nutrient-Stressed Animals Reveals an Interplay Between Microbial Serine Proteases and Mammalian Serine Protease Inhibitors. [PDF]
Stentz R+8 more
europepmc +1 more source
Abstract Aims Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation‐related proteins and HF risk remains unclear.
Xian‐Guan Zhu+9 more
wiley +1 more source
Serine protease inhibitor dipetalogastin-like from Galleria mellonella is involved in insect immunity. [PDF]
Kordaczuk J+4 more
europepmc +1 more source
The potential of fluorinated mono‐ and diketones as electrophilic warheads for reversible covalent drugs is described by studying their equilibria reactions with the protected nucleophilic amino acids serine, cysteine and lysine. Fluorinated diketones (FDKs) are electrophilic moieties holding unique molecular properties that make them potential ...
Yossi Zafrani+5 more
wiley +1 more source
Ingested house dust mite favors sensitization to egg white in mice independently of its proteinase activity. [PDF]
Benedé S+4 more
europepmc +1 more source
Inherited metabolic epilepsies–established diseases, new approaches
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source
Human Neutrophil Elastase: Characterization of Intra- vs. Extracellular Inhibition. [PDF]
Birk D+3 more
europepmc +1 more source
The Role of Proteins in the Sensory Perception/Organoleptic Properties of Food
Protein structure controls sensory attributes such as flavor, texture, and aroma. This can occur during amino acid breakdown, Maillard reactions and lipid–protein interactions which generate flavor profiles. Bioactive peptides also provide taste and health benefits.
Tharuka Wijesekara, Idaresit Ekaette
wiley +1 more source