Results 201 to 210 of about 267,153 (398)

Toxoplasma serology in patients with malignant diseases of the reticuloendothelial system [PDF]

open access: bronze, 1969
Charles L. Vogel, Milford N. Lunde
openalex   +1 more source

A multipart phase 1 study of the safety, pharmacodynamics and pharmacokinetics of ALG‐055009, a novel thyroid hormone receptor beta (THR‐β) agonist for metabolic dysfunction‐associated steatohepatitis (MASH), in healthy participants

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract ALG–055009 is an oral thyroid hormone receptor beta (THR‐β) agonist being evaluated for treating metabolic dysfunction–associated steatohepatitis (MASH). This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALG‐055009 and bioavailability/food effect.
Hakim Charfi   +11 more
wiley   +1 more source

Foundational Principles for the Quantitative Translation of T‐Cell Therapeutics for Hematologic Malignancies and Immunology

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
T‐cell engaging antibodies (TCEs) and chimeric antigen receptor (CAR) T cells (CAR‐T cells) are among precision medicine therapies that have revolutionized the treatment of hematologic cancers. Their success in oncology has piqued interest in translating this promise into additional indications, such as autoimmune disorders.
Peter Ashcroft   +6 more
wiley   +1 more source

hiPSC‐Derived Astrocytes From Individuals With Schizophrenia Induce a Dystrophic Phenotype in Microglial‐Like Cells

open access: yesGlia, EarlyView.
SCZ astrocytes display an increased pro‐inflammatory profile upon TNF‐α stimulation. Reactive SCZ astrocytes induce microglial‐like cells to assume a dystrophic phenotype. Reactive SCZ astrocytes limit iMGs' synaptoneurosome uptake and migration. ABSTRACT Neuroinflammation, particularly astrocyte reactivity, is increasingly linked to schizophrenia (SCZ)
Pablo L. Cardozo   +18 more
wiley   +1 more source

The Fibrosis‐4 score is associated with overall mortality and severe haematological toxicity in older patients with cancer: Analysis of two prospective cohort studies

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Liver function decreases with age, affecting the metabolism of many chemotherapy drugs. For older cancer patients, however, a standardized liver status screening method is lacking. Here, Fibrosis‐4 (FIB‐4) score was investigated for its utility as a non‐invasive method in predicting treatment toxicity and mortality in cancer patients age 70
Victoire de Salins   +14 more
wiley   +1 more source

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