Results 1 to 10 of about 2,360 (67)

Brain serotonergic fibers suggest anomalous diffusion-based dropout in artificial neural networks

Frontiers in Neuroscience, 2022
Random dropout has become a standard regularization technique in artificial neural networks (ANNs), but it is currently unknown whether an analogous mechanism exists in biological neural networks (BioNNs).
Christian Lee, Zheng Zhang, Skirmantas Janušonis   +2 more
doaj   +1 more source

Mechanosensitivity of Murine Lung Slowly Adapting Receptors: Minimal Impact of Chemosensory, Serotonergic, and Purinergic Signaling

Frontiers in Physiology, 2022
Murine slowly adapting receptors (SARs) within airway smooth muscle provide volume-related feedback; however, their mechanosensitivity and morphology are incompletely characterized.
Nicolle J. Domnik, Nicolle J. Domnik, Sandra G. Vincent, John T. Fisher   +3 more
doaj   +1 more source

Involvement of GABAergic and Serotonergic Systems in the Antinociceptive Effect of Jegosaponin A Isolated from Styrax japonicus

Molecules, 2023
The antinociceptive activity of the flower extracts of Styrax japonicus was confirmed in our previous study. However, the key compound for analgesia has not been distinguished, and the corresponding mechanism is obscure.
Lei He, Ying Zhou, Li Ma, Wencui Wang, Lei Yao   +4 more
doaj   +1 more source

High-resolution spatiotemporal analysis of single serotonergic axons in an in vitro system

Frontiers in Neuroscience, 2022
Vertebrate brains have a dual structure, composed of (i) axons that can be well-captured with graph-theoretical methods and (ii) axons that form a dense matrix in which neurons with precise connections operate.
Melissa Hingorani, Adele M. L. Viviani, Jenna E. Sanfilippo, Skirmantas Janušonis   +3 more
doaj   +1 more source

The modulation effects of repeated transcutaneous auricular vagus nerve stimulation on the functional connectivity of key brainstem regions along the vagus nerve pathway in migraine patients

Frontiers in Molecular Neuroscience, 2023
BackgroundPrevious studies have shown a significant response to acute transcutaneous vagus nerve stimulation (taVNS) in regions of the vagus nerve pathway, including the nucleus tractus solitarius (NTS), raphe nucleus (RN) and locus coeruleus (LC) in ...
Yiting Huang, Yue Zhang, Sierra Hodges, Hui Li, Zhaoxian Yan, Xian Liu, Xiaoyan Hou, Weicui Chen, Thalia Chai-Zhang, Jian Kong, Bo Liu   +10 more
doaj   +1 more source

A Comprehensive Review of the Current Status of the Cellular Neurobiology of Psychedelics

Biology, 2023
Psychedelic substances have gained significant attention in recent years for their potential therapeutic effects on various psychiatric disorders. This review delves into the intricate cellular neurobiology of psychedelics, emphasizing their potential ...
Blerida Banushi, Vince Polito
doaj   +1 more source

Methyleugenol Has an Antidepressant Effect in a Neuroendocrine Model: In Silico and In Vivo Evidence

Pharmaceuticals, 2023
Major depressive disorder is a severe mood disorder characterized by different emotions and feelings. This study investigated the antidepressant activity of the phenylpropanoid methyleugenol (ME) in adult female mice exposed to a stress model induced by ...
Mayara Cecile Nascimento Oliveira, Ikla Lima Cavalcante, Alana Natalícia de Araújo, Aline Matilde Ferreira dos Santos, Renata Priscila Barros de Menezes, Chonny Herrera-Acevedo, Natália Ferreira de Sousa, Jailane de Souza Aquino, José Maria Barbosa-Filho, Ricardo Dias de Castro, Reinaldo Nóbrega Almeida, Luciana Scotti, Marcus Tullius Scotti, Mirian Graciela Da Silva Stiebbe Salvadori   +13 more
doaj   +1 more source

A single dose of noradrenergic/serotonergic reuptake inhibitors combined with an antimuscarinic does not improve obstructive sleep apnoea severity

Physiological Reports, 2022
Previous trials have demonstrated that the combination of noradrenergic reuptake inhibitors with an antimuscarinic can substantially reduce the apnoea‐hypopnoea index (AHI) and improve airway collapsibility in patients with obstructive sleep apnoea (OSA).
Luke D. J. Thomson, Shane A. Landry, Simon A. Joosten, Dwayne L. Mann, Ai‐Ming Wong, Tim Cheung, Mulki Adam, Caroline J. Beatty, Garun S. Hamilton, Bradley A. Edwards   +9 more
doaj   +1 more source

Developmental Disruption of Erbb4 in Pet1+ Neurons Impairs Serotonergic Sub-System Connectivity and Memory Formation

Frontiers in Cell and Developmental Biology, 2021
The serotonergic system of mammals innervates virtually all the central nervous system and regulates a broad spectrum of behavioral and physiological functions.
Candela Barettino, Álvaro Ballesteros-Gonzalez, Andrés Aylón, Xavier Soler-Sanchis, Leticia Ortí, Selene Díaz, Isabel Reillo, Francisco García-García, Francisco José Iborra, Cary Lai, Nathalie Dehorter, Xavier Leinekugel, Nuria Flames, Isabel Del Pino   +13 more
doaj   +1 more source

Targeted anatomical and functional identification of antinociceptive and pronociceptive serotonergic neurons that project to the spinal dorsal horn

eLife, 2023
Spinally projecting serotonergic neurons play a key role in controlling pain sensitivity and can either increase or decrease nociception depending on physiological context.
Robert Philip Ganley, Marilia Magalhaes de Sousa, Kira Werder, Tugce Öztürk, Raquel Mendes, Matteo Ranucci, Hendrik Wildner, Hanns Ulrich Zeilhofer   +7 more
doaj   +1 more source